Disclosed herein is an apparatus comprising: a first radiation source configured to produce a first divergent radiation beam toward an object; a second radiation source configured to produce a second divergent radiation beam toward the object; and an image sensor; wherein the object is configured to rotate with respect to the image sensor, the first radiation source, and the second radiation source, and wherein relative positions among the image sensor, the first radiation source, and the second radiation source are fixed.

A multi-axis imaging system comprising an imaging gantry with an imaging axis extending through a bore of the imaging gantry, a support column that supports the imaging gantry on one side of the gantry in a cantilevered manner, and a base that supports the imaging gantry and the support column. The imaging system including a first drive mechanism that translates the gantry in a vertical direction relative to the support column and the base, a second drive mechanism that rotates the gantry with respect to the support column between a first orientation where the imaging axis of the imaging gantry extends in a vertical direction parallel to the support column and a second orientation where the imaging axis of the gantry extends in a horizontal direction parallel with the base, and a third drive mechanism that translates the support column and the gantry in a horizontal direction along the base.

Systems and methods relate to multi-modal imaging of tissue combined with highly focused radiation interventions. The system is a portable multimodal imaging unit that integrates imaging and image analysis. The system can be retrofitted to use with any commercial radiation therapy machine. In one aspect, a system integrates various imaging modalities into a single, coordinated structure. The system integrates X-ray and cone beam computed tomography (CBCT), optical imaging (such as bioluminescent imaging (BLI), fluorescence tomography (FT)), and positron emission tomography (PET) imaging in a single, self-contained structure.

The present invention is directed to an alternative geometric calibration method based on a calibration phantom with multiple line-shaped markers. The markers can in some embodiments take the form of radio-opaque wires. Line fiducials overcome the occlusion hazards of spherical fiducials, because their projections overlap very mildly as long as the wires are mutually non-coplanar in 3D. This makes the phantom amenable to a wider range of orbits and less sensitive to phantom positioning. Equations relating the pose of 3D line-shaped objects to their 2D radiographic projections are then used as the basis for view-by-view geometry estimation. The technique can flexibly accommodate a wide range of different CT scan trajectories, including strongly noncircular trajectories known to provide better image quality than standard circular scans.

A method of sequential monoscopic tracking is described. The method includes generating a plurality of projections of an internal target region within a body of a patient, the plurality of projections comprising projection data about a position of an internal target region of the patient. The method further includes generating external positional data about external motion of the body of the patient using one or more external sensors. The method further includes generating, by a processing device, a correlation model between the projection data and the external positional data by fitting the plurality of projections of the internal target region to the external positional data. The method further includes estimating the position of the internal target region at a later time using the correlation model.

A medical imaging system includes a movable station having a C-arm, a collector, an X-ray beam emitter, and a controller. The collector is attached to a first end of the C-arm. The X-ray beam emitter faces the collector to emit an X-ray beam in a direction of the collector and is attached to a second end of the C-arm. The controller moves one of the X-ray beam emitter and the collector to a first offset position along a lateral axis orthogonal to the arc, and obtains a first set of images by rotating the collector and the X-ray beam emitter along the arc about a scanned volume. The controller moves the one of the X-ray beam emitter and the collector to a second offset position along the lateral axis, and obtains a second set of images. The controller combines the first and second set of images to generate a three-dimensional image of the scanned volume.

Various methods and systems are provided for medical imaging systems. In one example, an imaging system comprises: a C-shaped gantry; an x-ray tube coupled to a first end of the C-shaped gantry; an x-ray detector coupled to a second end of the C-shaped gantry, opposite to the x-ray tube; and a controller with computer readable instructions stored on non-transitory memory that when executed, cause the controller to: identify a reference image; determine a target electrical current based on the reference image; determine a corrected electrical current based on the target electrical current; and transition an electrical current provided to the x-ray tube to the target electrical current by commanding the electrical current to the corrected electrical current while maintaining a constant voltage provided to the x-ray tube.

An electromagnetic tracking system including a patient support element and an electromagnetic field generator. The patient support element is superposed relative to the electromagnetic field generator, and the electromagnetic field generator is selectively moveable relative to the patient support element.

A computer based method of obtaining a 3D image of a part of a patient's body is disclosed, based on a fraction image having a limited field-of-view and extending the field of view with information from an image of the patient's outline, obtained from a surface scan of the patient. Anatomical data from the planning image are preferably used to fill in the outline image, by means of a contour-guided deformable registration between the planning image and contour.

A cone beam CT scanner comprises a receiving section configured to receive a breast of the subject whilst in the supine position, a radiation imaging section comprising an x-ray tube and a detector which face each other and have the receiving section interposed therebetween, and a drive unit operable to move the receiving section to a position suitable for imaging the breast of the subject. A method for breast radiography is also disclosed.