This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a TNF inhibitor.

A tethered laparoscopic probe is provided, the tethered laparoscopic probe for deployment through a trocar into a cavity of a subject to detect gamma radiation from a radiopharmaceutical administered to the subject. The laparoscopic probe comprises a probe head shaped for insertion through the trocar and configured to be freely moveable within the cavity. The probe head comprises an elongate casing comprising radiation shielding for inhibiting gamma radiation from passing through the probe head, the radiation shielding having a detection aperture for admitting gamma radiation. The probe head further comprises a gamma radiation detector arranged within the casing, the gamma radiation detector configured to detect gamma radiation through the detection aperture of the casing. The probe head further comprises means for, in use, facilitating the localization of a source of radiation from the radiopharmaceutical within the cavity. The laparoscopic probe further comprises a tether coupled to the probe head and for, in use, tethering the probe head through the trocar.

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and monitoring of radiotherapy are presented. In some embodiments, the present disclosure relates to a device having a cannula that may include a measurement chamber, a radiation detector and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., radiotracers used in radiopharmaceuticals) and measure levels and concentrations of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, particles emitted by the radioactive material interact with a scintillation material, resulting in the release of light that may be transmitted, via the scintillation material and/or fiber optic material, to an optical detectors or processor for processing. In some embodiments, particle absorbing materials may be used to limit measurements to materials within the measurement chamber or other area of interest.

An apparatus for detecting a locating medium in tissue includes a probe, and a console. The probe includes a handle and a detector disposed on a distal end of the probe. The console is in communication and includes a display. The display has a first graphical representation and a second graphical representation. The first graphical representation is configured to depict a count real-time count based on a signal from the detector. The second graphical representation is configured to depict a target count.

A surgical instrument for operating hip joint osteoarthritis in a human patient is provided. The hip joint comprises an acetabulum, being a part of the pelvic bone, and a caput femur, being the proximal part of the femoral bone. The surgical instrument is adapted to assist in the operating of the hip joint osteoarthritis from the abdominal side of the pelvic bone of said human patient.

A dental x-ray sensor holder adapted for engaging a portion of an x-ray tube and holding a digital sensor inside a patient's mouth. The holder includes a holder base arm with a first and second tube arm. The first and second tube arms are adapted for engaging a portion of a side of the x-ray tube and hold the tube in a fixed position next to a patient's cheek. The holder also includes a buccal arm adapted for receipt inside the patient's mouth and next to a buccal side of a tooth under review. The buccal arm includes an elongated arm opening for receiving a portion of a sliding interoral position arm. The position arm is attached to a digital x-ray sensor. The position arm is used to adjust the sensor in the middle of the patient's mouth.

A radiation therapy apparatus capable of improving the accuracy of a dose distribution includes an X-ray generation device that is provided at an arm portion of a rotation gantry, a radiation detector that is insertable into the body of a patient, a dose calculation device, and a feedback control device. An X-ray generated due to collision of an electron beam with a target in the X-ray generation device is applied to an affected part (cancer) of a patient on a bed. The radiation detector which is insertable into the body detects the X-ray applied to the affected part so as to output a photon to obtain a dose rate and a dose based thereon. The feedback control device either controls the X-ray generation device such that the obtained dose becomes a set dose or controls the radiation generation device such that the obtained dose rate becomes a set dose rate.

A method of reconstructing an image of a colon, including receiving scan data of a colon taken by an imaging capsule that traverses the colon; wherein the imaging capsule emits X-ray radiation inside the colon and includes detectors that detect photons that are returned toward the imaging capsule from X-ray fluorescence and Compton back scattering interactions responsive to the radiation; and wherein the scan data includes counts of photons detected by each detector from X-ray fluorescence and Compton back scattering interactions; defining an initial guess of a geometry of a contour of a slice of the colon; calculating count values for each detector responsive to the geometry using a forward model; comparing the calculated count values of each detector with the values from the scan data; if the results of the comparison do not indicate reaching an optimal match then adjust the defined geometry and repeat the calculating and comparing.

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and monitoring of radiotherapy are presented. In some embodiments, the present disclosure relates to a device having a cannula that may include a measurement chamber, a radiation detector and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., radiotracers used in radiopharmaceuticals) and measure levels and concentrations of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, a plunger may be utilized to draw blood through a first opening into the measurement chamber and then return it to the bloodstream. In some embodiments, particle absorbing materials may be used to limit measurements to materials within the measurement chamber or other area of interest.

In one embodiment, a sensor includes a capsule having a cavity and a sheath, a transducer coupled to electronic circuitry in the cavity, and a clip outside the capsule. The capsule and the clip are configured to hold in vivo an object within an opening between the capsule and the clip. The transducer is configured to detect an incoming signal indicative of a physiological parameter of the object being held, and the electronic circuitry is configured to wirelessly transmit a signal containing information about the physiological parameter obtained from the incoming signal. The sensor is part of a measurement system to measure the physiological parameter. Another embodiment describes a method using the measurement system.