Multiple interactions, such as Compton scattering, inside a PET detector are used to predict an incident photon's direction for identifying true coincidence events versus scatter/random coincidence events by creating a cone shaped shell projection defining a range of possible flight directions for the incident photon. The disclosed techniques can be used as prior information to improve the image reconstruction process. The disclosed techniques can be implemented in a LYSO/SiPM-based layer stacked detector, which can precisely register multiple interactions' 3D position.

A system and method includes determination of a region of interest of an imaging subject, generation of a first linear attenuation coefficient map of the imaging subject, the first linear attenuation coefficient map generated to associate voxels of the region of interest of the imaging subject with greater linear attenuation coefficients than voxels of other regions of the imaging subject, attenuation-correction of a plurality of tomographic frames of the imaging subject based on the first linear attenuation coefficient map to generate a second plurality of tomographic frames, and determination of tomographic inconsistency of the second plurality of tomographic frames. Some aspects further include generation of a second linear attenuation coefficient map of the imaging subject, attenuation-correction of the plurality of tomographic frames based on the second linear attenuation coefficient map to generate a third plurality of tomographic frames, and reconstruction of a three-dimensional image based on the third plurality of tomographic frames and the determined tomographic inconsistency.

A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.

A nuclear medicine diagnostic apparatus according to a present embodiment includes a plurality of units of detector that detects gamma rays, and each of the units of detector includes detection circuitry, generation circuitry, and first production circuitry. The detection circuitry detects an analog signal based on a result of detecting the gamma rays. The generation circuitry generates a clock signal. The first production circuitry produces time information by converting the analog signal into a digital signal on the basis of the clock signal.

A radiation detector module includes a frame, a module circuit board connected to the frame, detector units that each include radiation sensors disposed above the frame and electrically connected to the module circuit board, and an optically and infrared radiation opaque, X-ray transparent, electrically insulating detector shield covering a top surface and at least one side surface of the radiation sensors.

A nuclear medicine diagnosis apparatus according to an embodiment includes a processing circuit. The processing circuit is configured to obtain nuclear medicine data; to time-divide the nuclear medicine data into at least first nuclear medicine data and second nuclear medicine data; and to identify a biological accumulation region, on the basis of a temporal change in data values included in the first nuclear medicine data and the second nuclear medicine data.

Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.

Described is a directional gamma detector including a detection probe and a handgrip, wherein the detection probe includes: a supporting rod and a detection head coupled or integrated with a first end of the supporting rod. The detection head includes a plurality of detection elements distinct from each other for simultaneously detecting gamma rays directed in different directions and including at least one scintillation crystal and a corresponding first electronic conversion circuitry. Each detection element is associated with a respective collimator. The handgrip is equipped internally with a second electronic circuitry for converting the signals. The detection probe, and in particular a second end of the supporting rod, is reversibly connectable to the handgrip by a mechanical connector equipped with electrical contacts for transferring the signals from the first electronic conversion circuitry to the second electronic conversion circuitry.

An imaging system is provided that includes a gantry defining a bore configured to accept an object to be imaged, wherein the gantry is configured to rotate about the bore. The system includes multiple detector units mounted to the gantry and configured to rotate with the gantry around the bore in rotational steps, each detector unit configured to sweep about a corresponding axis and acquire imaging information while sweeping about the corresponding axis. The system includes at least one processor operably coupled to at least one of the detector units that is configured to acquire, during an initial portion of a scan, imaging information of the object based on an initial contour and to detect an actual emission contour based on the imaging information. The processor is configured to update a scan sweep plan based on the detected actual emission contour for a remaining portion of the scan.

The present disclosure relates, in part, to a scanning sufficiency apparatus that computes whether a handheld scanning device has scanned a volume for a sufficiently long time for there to be detections and then indicate to the user that the time is sufficient in 3-D rendered voxels. Also described is a hand held medical navigation apparatus with system and methods to map targets inside a patient's body.