Various systems, devices, and methods for facilitating efficient anatomical registration in surgical navigation are disclosed. Such systems and devices can have a data collection unit and a scaling device. The scaling device has a main body having an anatomical registration feature defined therein and at least one scaling marker pathway that is selectively oriented with respect to the anatomical registration feature to facilitate repeatable gross placement of a scaling marker relative to a selected anatomical feature. The scaling marker is selectively displaceable along a scaling marker pathway about and between a first end and a second end thereof to fine-tune scaling marker placement prior to image capture.

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

An embodiment in accordance with the present invention provides a device and method for a quantitatively calibrated computed tomography scanner. The device includes a gantry configured for receiving a patient or part of a patient. The gantry includes an X-ray source and a detector positioned opposite said X-ray source, such that said detector receives the X-rays emitted from the X-ray source. Calibration phantoms are integrated with the gantry and/or a device within the scanner so as to allow for calibration in quantitative CT measurements of Hounsfield units and/or bone mineral density.

Disclosed is a miniaturized phantom that can be placed against breast tissue during mammography. The phantom is provided with various radiological features that can be compared to the image of the breast tissue. The phantom is situated to be included in one or more mammography images. The phantom is at least partially opaque to the radiation of the image and contains features such as step wedges of different density, pillars that show radiation incidence, sweep gratings that show variations of radiation amplitude and a unique bar code to identify patients. The phantoms can be used in images containing them to assess various radiological features in a quantitative way.

A method for correction of an input dataset is disclosed. In an embodiment, the method includes acquisition of an input dataset comprising at least one data error; determination of a correction function; creation of a corrected output dataset by application of the correction function to the input dataset; and outputting of the corrected output dataset. The correction function is embodied to bring about a reduction of at least two data errors that mutually influence one another in the input dataset.

The disclosure relates to a system and method for medical imaging. The method may include: move, by a motion controller, a phantom along an axis of a scanner to a plurality of phantom positions; acquire, by a scanner of the imaging device, a first set of PET data relating to the phantom at the plurality of phantom positions; and store the first set of PET data as an electrical file. The length of an axis of the phantom may be shorter than the length of an axis of the scanner, and at least one of the plurality of phantom positions may be inside a bore of the scanner.

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

A multiple frame x-ray imaging system is disclosed with capability of differential x-ray exposure of different input areas of an image intensifier or other x-ray detector. Collimators are provided to control the amount of radiation in various regions of the image and image processing is provided to provide the display of images of different qualities.

A first image data set and at least one second image data set are captured, and a contrast-enhanced image data set and a non-contrast image data set are determined based on the first and the at least one second image data set. The perfusion image data set is calculated based on a ratio of image values of the contrast-enhanced image data set and locally corresponding image values of the non-contrast image data set, and the perfusion image data set is provided via a second interface.

3D image data of a skeletal portion is acquired. A location of a proximal portion of a tool is calculated and a location is derived of a distal portion of the tool with respect to the skeletal portion, with respect to the 3D image data. A display indicates the derived location. First and second 2D images of the distal portion of the tool are acquired from two different poses of a 2D imaging device with respect to the subject and registered with the 3D image data. The location of the distal portion with respect to the 3D image data of the skeletal portion is determined based on the registration and an identified location of the distal portion within the 2D x-rays. Based upon the determined location, the display updates the indicated location of the distal portion. Other embodiments are also described.