The invention describes a device (10) for dispensing microbubbles (30) for cell sonoporation, comprising: a tube configured to receive a vial (20) containing a solution (26) of microbubbles (30), at least two catheters (11, 12) arranged inside the tube and opening into the vial (20) when the latter is received by the tube,
wherein, when the first catheter (11) is connected to a first air injection source, air can be injected into the vial (20) via the first catheter so as to generate an overpressure therein, the microbubbles (30) contained in the vial (20) entering the second catheter (12) and moving toward its second end (122). The invention also relates to a sonoporation device, a sonoporation process and a computer program product.

An ultrasound device for modulating brain activity may include a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions.

In order to enable more accurate calibration of brain, there is provided a system for creating a hemodynamic brain atlas for calibration of brain hemodynamics. The system comprises a non-invasive transcranial neurostimulation device, a non-invasive neuromonitoring device, and a computing device. The non-invasive transcranial neurostimulation device is configured to induce neuronal activity to evoke a hemodynamic response in a target region of interest (ROI) of a brain of a human subject. The non-invasive neuromonitoring device is configured to monitor the evoked hemodynamic response in the target ROI. The computing device configured to determine a set of parameters representing a hemodynamic response function, HRF, of the evoked hemodynamic response in the target ROI, and to associate the set of parameters of the HRF with the target ROI to form the hemodynamic brain atlas.

Disclosed herein is an ultrasonic imaging apparatus and a control method thereof. The ultrasonic imaging apparatus includes an acquisition unit configured to acquire a volume data of an object and a process configured to determine whether an acquisition position of the volume data is within an allowable range by using pre-stored landmark information and configured to acquire a plurality of reference planes from the volume data when the acquisition position of the volume data is within the allowable range.

The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (20), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.

A medical imaging and therapy device is provided that may include any of a number of features. The device may include a Histotripsy transducer, a generator and controller configured to deliver Histotripsy energy from the transducer to target tissue, and an imaging system. In some embodiments, a method of treating tissue with Histotripsy energy comprises positioning a focus of a histotripsy transducer on a target tissue, delivering histotripsy energy from the histotripsy transducer through a bone aberrator, forming a histotripsy bubble cloud on the focus, and preventing the formation of secondary histotripsy bubble clouds without implementing an aberration correction algorithm.

The disclosed subject matter related to methods and apparatus for determining brain swelling and brain shifting in a patient as well as predicting a possible resultant increase in intracranial pressure in the patient. The apparatus can include a transducer such as an ultrasound transducer communicatively connected to a controller via wires or via wireless communications device(s). A monitor and/or alarm device can be provided to notify a practitioner when the controller has determined brain swelling is occurring and/or when an imminent increase in intracranial pressure is likely to occur.

A system includes a processing circuit configured to receive signals corresponding ultrasound data, extract a blood flow waveform from the signals, the blood flow waveform corresponds to a single pulse of the signals, determine a curvature characteristic of the blood flow waveform based on a plurality of local curvature parameters, and identify a medical condition for the blood flow waveform using the blood flow waveform. Each of the plurality of local curvature parameters indicates a degree to which the blood flow waveform deviates from a straight line at a location on the blood flow waveform.

A method of evaluating a cerebrovascular health of a patient includes causing a patient to exercise for an exercise duration at an exercise intensity, collecting cerebrovascular information from the patient during the exercise duration, collecting cardiovascular information from the patient during the exercise duration, correlating the cerebrovascular information to the cardiovascular information to create a correlated cerebrovascular curve, and determining a cerebrovascular health and viability for cerebrovascular therapy.

The three-dimensional ultrasound imaging method comprise emitting an ultrasonic wave to a fetal head; receiving an ultrasonic echo to acquire an ultrasonic echo signal; acquiring three-dimensional volume data of the fetal head according to the ultrasonic echo signal; detecting a median sagittal section from the three-dimensional volume data according to features of the median sagittal section of the fetal head; determining a facing orientation of the fetal head in the median sagittal section; displaying the median sagittal section as an image suitable for observation according to the facing orientation of the fetal head.