A system for use in managing a neuromodulation therapy includes an ultrasound transducer array controlled by a control unit to deliver ultrasound waveforms for causing modulation of neural tissue in a patient. The system acquires data indicating a response to the modulation, analyzes the acquired data to determine correlation data between a response to the modulation and an ultrasound control parameter, and reports the correlation data to enable identification of at least one therapy parameter to be used to deliver a neuromodulation therapy to the patient by a therapy delivery system.

System for non-invasive measuring of an intracranial reserve space (ICRS) parameter of a mammalian subject, comprising a multi-frequency ultrasound probe configured, beginning at a start time, to emit and receive ultrasound waves into and from the subject's head and to produce a signal of brain tissue pulsation; an instrument configured to non-invasively partially occlude an internal jugular vein (IJV) starting at the start time and including a second ultrasound probe producing a second signal; and a computer system configured to receive the signal, the second signal and the start time, the computer system also configured, using one or more processors, to derive from the signal an intracranial brain tissue pulsation waveform and from the second signal images of the IJV, and to determine a length of time from the start time to a subsequent time at which the waveform is sufficiently compressed so as to exhibit a predefined decline in variability.

A non-Hermitian complementary metamaterial (NHCMM). Acoustic transmission systems including an acoustic wave generator configured to generate an acoustic wave and propagate the acoustic wave through a tissue of a specimen, and the NHCMM, which is configured to add a first amount of energy amplification coherently to the acoustic wave to account for energy loss in the acoustic wave as a result of the wave propagating through the tissue of the specimen. The acoustic wave generator can be an ultrasound generator, and the tissue can be a cranium.

Arrangements described herein relate to systems, apparatuses, and methods for managing gel on a subject to provide gel on a first area of the subject, including controlling a transducer to move to a second area of the subject and controlling the transducer to move the gel to the first area from the second area.

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multichannel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multimodal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

Provided herein are cranial implant devices that include a cranial implant housing configured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject. The cranial implant housing comprises a substantially anatomically-compatible shape and is fabricated from one or more sonolucent materials that permit transmission of mechanical waves through the sonolucent materials when the cranial implant device is subgaleally implanted. The cranial implant housing also includes a pressure sensor operably connected to the cranial implant housing, which pressure sensor is configured to sense intracranial pressure (ICR). The cranial implant housing also includes at least a first controller operably connected to the pressure sensor, which first controller is configured to selectively effect the pressure sensor to sense the ICR within a cranium of the subject to generate ICP data and to transmit the ICP data to an ICP data receiver. In addition, the cranial implant housing also includes a power source operably connected or connectable at least to the first controller. Other aspects are directed to various related systems, computer readable media, and methods.

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions.

System for non-invasive measuring of an intracranial reserve space (ICRS) parameter of a mammalian subject, comprising a multi-frequency ultrasound probe configured, beginning at a start time, to emit and receive ultrasound waves into and the subject's head and to produce a signal of brain tissue pulsation; an instrument configured to non-invasively partially occlude an internal jugular vein (IJV) starting at the start time and including a second ultrasound probe producing a second signal; and a computer system configured to receive the signal, the second signal and the start time, the computer system also configured, using one or more processors, to derive from the signal an intracranial brain tissue pulsation waveform and from the second signal images of the IJV, and to determine a length of time from the start time to a subsequent time at which the waveform is sufficiently compressed so as to exhibit a predefined decline in variability.

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multi-channel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multi-modal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

A dynamic headset system is provided. The dynamic headset system includes a head cradle configured to receive a head of a subject and having a bottom surface configured to face a platform on which the dynamic headset apparatus is placed. The dynamic headset system further includes a device including an instrument adjacent to the head of the subject when the head of the subject is in the head cradle.