A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier, Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

Arrangements described herein relate to systems, apparatuses, and methods for managing gel on a subject to provide gel on a first area of the subject, including controlling a transducer to move to a second area of the subject and controlling the transducer to move the gel to the first area from the second area.

The present invention relates to a wearable (or fastenable, or adherable) vibration massage system directly localized, focused and engaged upon or overlying a selected target artery of a user. The vibration massage waves are advantageously derived from religious texts, whereby a user can simultaneously listen to audio of the in real time, thereby providing a synchronized, harmonized tactile and auditory experience. The provided system is essentially MUSical vibration applied upon a target ARTteryhence is hereinafter described as the MUSART therapy system. Various modes of application of the tactile vibratory stimulus, as well as modes for invasive delivery of acoustic stimulation directly in contact with a target artery, are presented.

An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source.

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions.

Various approaches for detecting cavitation signals from a target region of a patient during a focused ultrasound procedure include an ultrasound transducer; an imaging device for acquiring physiological characteristics of multiple anatomical regions through which the cavitation signals from the target region travel; a controller configured to select one or more of the anatomical regions based at least in part on the physiological characteristics thereof and map the selected anatomical region(s) to one or more corresponding skin regions; and one or more cavitation detection devices attached to the corresponding skin region(s).

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multichannel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multimodal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

According to some aspects, there is provided a device configured to determine a measure of brain tissue motion in a brain, comprising: at least one transducer configured to transmit an acoustic signal to at least one region of the brain and receive a subsequent acoustic signal from the at least one region of the brain; and at least one processor configured to: determine the measure of brain tissue motion in the at least one region of the brain by processing the subsequent acoustic signal, wherein processing the subsequent acoustic signal comprises filtering the subsequent acoustic signal. Filtering the subsequent acoustic signal may comprise one of spatiotemporal filtering, signal decomposition, tissue tracking, and/or spectral clustering.

Disclosed herein is an ultrasonic imaging apparatus and a control method thereof. The ultrasonic imaging apparatus includes a display, and at least one processor. The at least one processor obtains ultrasound image data acquired by an ultrasonic probe, recognizes at least one anatomical feature from the obtained ultrasound image data, automatically acquires at least one reference plane image based on the recognized at least one anatomical feature, and displays the acquired at least one reference plane image on the display.

A method may include positioning a catheter, including at least one electrode, within an esophagus such that the electrode is proximate to at least one sympathetic ganglion. The methods may further include recruiting the sympathetic ganglion via an electrical signal, monitoring the recruitment of the sympathetic ganglion, and, based on the monitoring the recruitment of the sympathetic ganglion, adjusting the electrical signal from the at least one electrode.