A device is for estimating the central blood pressure of a subject. The device comprises a sensor patch comprising an array of sensors configured to measure an indication of the blood pressure of a peripheral blood vessel and perform ultrasound imaging of the peripheral blood vessel. The device also comprises a processor configured to obtain a peripheral pressure signal comprising a pressure waveform from the indication of the blood pressure from the sensor patch and derive an image of the peripheral blood vessel from the signals received from the sensor patch. A vessel diameter is determined from the image of the peripheral blood vessel over time comprising a vessel diameter waveform and an estimate of the central blood pressure of the subject is derived from the pressure waveform and/or the vessel diameter waveform.

Methods, systems, and techniques for the contactless operation of capacitive micromachined ultrasonic transducers (CMUTs) and CMUT arrays. Contactless operations refers to both the contactless transfer of energy and information between the transducer(s) and the controlling subsystem. A system includes a CMUT, a first alternating current voltage source, a first inductor electrically coupled to the first voltage source, and a second inductor electrically coupled to the CMUT. The second inductor is physically decoupled from, and positioned to be wirelessly coupled to, the first inductor. A contactless configuration is useful for a wide range of applications, from wearable transducers to high-end ultrasound imaging systems.

Aspects of the technology described herein related to controlling, using control circuitry, modulation circuitry to modulate and delay first ultrasound data generated by first ultrasound transducers positioned at a first azimuthal position of an ultrasound transducer array of an ultrasound device and second ultrasound data generated by second ultrasound transducers positioned at a second azimuthal position of the ultrasound transducer array of the ultrasound device, such that the first ultrasound data is delayed by a first delay amount and the second ultrasound data is delayed by a second delay amount that is different from the first delay amount. The first and second ultrasound data received from the modulation circuitry may be filtered and summed. The ultrasound transducer array, the control circuitry, the modulation circuitry, the filtering circuitry, and the summing circuitry may be integrated onto a semiconductor chip or one or more semiconductor chips packaged together.

A fully integrated autonomous wearable ultrasonic-system-on-patch (USoP) includes a miniaturized flexible control circuit is designed to interface with an ultrasound transducer array for signal pre-conditioning and wireless data communication. Artificial Intelligence (e.g., machine learning) may be used to track moving tissue targets and assist the data interpretation. In one implementation, the USoP allows continuous tracking of physiological signals from tissues as deep as 164 mm. On mobile subjects, the USoP can continuously monitor physiological signals, including central blood pressure, heart rate, and cardiac output, for as long as e.g., twelve hours. This result enables continuous autonomous surveillance of deep tissue signals.

A process of monitoring heart valve function involves placing one or more transducers on a patient's body, receiving, using the one or more transducers, one or more signals indicating a blood flow velocity profile associated with a heart of the patient, identifying a first peak in the blood flow velocity profile, and determining a severity of a dysfunction of a first heart valve of the heart based on the first peak.

A system comprising a multi-modal ultrasound probe configured to operate in a plurality of operating modes associated with a respective plurality of configuration profiles; and a computing device coupled to the handheld multi-modal ultrasound probe and configured to, in response to receiving input indicating an operating mode selected by a user, cause the multi-modal ultrasound probe to operate in the selected operating mode.

A system for monitoring blood flow in a patient, the system comprising: a single-element disc-shaped ultrasound transducer for fastening to the patient and a controller subsystem. The controller subsystem is configured to: control the ultrasound transducer to transmit a series of plane-wave pulses into the patient in a propagation direction; sample reflections of the plane-wave pulses, received at the ultrasound transducer, from a region within the patient, to generate pulse-Doppler response signals; and process the pulse-Doppler response signals to calculate a blood flow curve for waveform analysis.

A universal ultrasound device having an ultrasound probe includes a semiconductor die; a plurality of ultrasonic transducers integrated on the semiconductor die, the plurality of ultrasonic transducers configured to operate a first mode associated with a first frequency range and a second mode associated with a second frequency range, wherein the first frequency range is at least partially non-overlapping with the second frequency range; and control circuitry configured to: control the plurality of ultrasonic transducers to generate and/or detect ultrasound signals having frequencies in the first frequency range, in response to receiving an indication to operate the ultrasound probe in the first mode; and control the plurality of ultrasonic transducers to generate and/or detect ultrasound signals having frequencies in the second frequency range, in response to receiving an indication to operate the ultrasound probe in the second mode.

A system for calibration-free cuff-less evaluation of blood pressure is proposed. The system includes an ultrasound-based arterial compliance probes and a controller unit connected to the said probe. The ultrasound transducers measure the change in arterial dimensions, pulse wave velocity, and other character traits of an arterial segment over continuous cardiac cycle, which is then used to evaluate blood pressure parameters without any calibration procedure using dedicated mathematical models. The pressure sensor/force sensor/biopotential transducers/accelerometric sensors measure a pressure acting on a skin surface at a measurement site, an internal arterial transmural pressure level, an applied pressure or a hold-down pressure on the skin surface or an arterial site, biopotential and/or plethysmograph signal, arterial vibrations acting on the measurement site as a function of the arterial pressure and the mechanical characteristics and/or a function of the applied/hold-down pressure and/or function of external factors.

A method for diagnosing a joint condition includes in one embodiment: creating a 3d model of the patient specific bone; registering the patient's bone with the bone model; tracking the motion of the patient specific bone through a range of motion; selecting a database including empirical mathematical descriptions of the motion of a plurality actual bones through ranges of motion; and comparing the motion of the patient specific bone to the database.