The method of bonding an interposer and an integrated circuit chip includes preparing an interposer including an insulator and conductive lines each having one end exposed to a first surface of the insulator and another end exposed to a second surface opposite to the first surface; placing a bonding mask on the interposer; forming through-holes on the bonding mask before or after the placing of the bonding mask on the interposer; filling the plurality with a conductive material; and bonding an integrated circuit chip to the bonding mask.

A replaceable attachment for an ultrasound probe includes a ring-like fastening region for fastening the attachment to the ultrasound probe, and a flexible membrane arranged on the fastening region. A first liquid or gel-like contact medium is applied to an inner contact surface of the membrane. The contact surface makes contact with an end face of the ultrasound probe when an attachment is fastened to the ultrasound probe. Before the attachment is fastened, the first contact medium is distributed on the contact surface in such a manner that, in an array region of the contact surface, a quantity of the first contact medium per surface is at least twice as large as in a remaining region of the contact surface. A positioning and extent of the array region is adapted to a positioning and extent of a piezo array of the ultrasound probe.

An ultrasound imaging system includes a thermally conductive frame and a number of electronic components and a display that are sealed within the frame. The frame further includes a plenum extending through the frame with surfaces that are thermally coupled to the electronic components and the display. An active cooling mechanism, such as one or more fans, moves air through the plenum to remove heat generated by the electronic components and display. The plenum is environmentally sealed so that moisture, dust, air or other contaminants drawn into the plenum do not contact the sealed electronic components and display in the frame.

A method for locating a plurality of elements comprising a flexible ultrasound phased array. The method includes constructing a matrix of traveltimes by iteratively transmitting a signal from one element of the plurality and receiving the signal at each of the other elements of the plurality. Traveltimes are derived from each received signal and arrayed in a matrix. Relative positions of the first element of the plurality and the last element of the plurality are established and the locations of the remaining elements of the plurality are iteratively modeled to fit the matrix of traveltimes.

A fractionated photoacoustic flow cytometry (PAFC) system and methods for the in vivo detection of target objects in biofluidic systems (e.g., blood, lymph, urine, or cerebrospinal fluid) of a living organism is described. The fractionated system includes a fractionated laser system, a fractionated optical system, a fractionated acoustic system, and combinations thereof. The fractionated laser system includes at least one laser or laser array for pulsing a target object within the circulatory vessel with fractionated focused laser beams. The fractionated optical system separates one or several laser beams into multiple beams in a spatial configuration on the skin above the circulatory vessel of the living organism. The fractionated acoustic system includes multiple focused ultrasound transducers for receiving photoacoustic signals emitted by the target object in response to the fractionated laser beams.

Provided in the present application is an ultrasonic probe, including: an ultrasonic transducer configured to send/receive an ultrasonic signal; a housing including a top plate and a side wall that collectively define a cavity with an opening located below the cavity, wherein a top portion of the ultrasonic transducer is configured to be accommodated in the cavity via the opening; and an elastic element accommodated in the cavity, the elastic element being connected to the top portion of the ultrasonic transducer and the top plate of the housing, and the elastic element being configured to provide an elastic force to the ultrasonic transducer to enable part of the ultrasonic transducer to retract and spring back within the cavity. Further provided in the present application are a scanning assembly including the ultrasonic probe and an ultrasonic imaging device including the scanning assembly.

Estimation of vibration amplitude of intra-capillary micro-bubbles driven to vibrate with an incident ultrasound wave with amplitude and frequency to adjust the drive amplitude of the incident wave to obtain specified vibration amplitude of extra-capillary tissue. Estimation uses transmission of M groups of pulse complexes having low frequency pulse (LF) at bubble drive frequency, and high frequency (HF) pulse with angular frequency ω.sub.H> ~ 5 ω.sub.L, and pulse duration shorter than π/4ω.sub.L along HF beam. The phase between HF and LF pulses is ω.sub.Lt.sub.m for each group, where t.sub.m varies between the groups. Within each group, LF pulse varies between pulse complexes in amplitude and/or, where the LF pulse can be zero for a pulse complex, and LF pulse is different from zero for pulse complex within each group. HF receive signals are processed to obtain a parameter relating to bubble vibration amplitude when the HF pulse hits bubble.

Performing retrospective dynamic transmit focusing beamforming for ultrasound signals by a) transmitting plural transmit beams, each transmit beam centered at a different position along array, having width or aperture encompassing plural laterally spaced line positions, each transmit beam width or aperture overlapping width or aperture of adjacent transmit beam or more laterally spaced transmit beams; b) receiving echo signals; c) processing echo signals to produce plural receive lines of echo signals at laterally spaced line positions within width or aperture of transmit beam; d) repeating steps b), (c) for additional transmit beams of plural transmitted transmit beams; e) equalizing phase shift variance among receive lines at common line position resulting from transmit beams of different transmit beam positions concurrently with steps c), d); f) combining echo signals of receive lines from different transmit beams spatially related to common line position to produce image data; g) produces an image using image data.

An overlay system can include a substantially planar overlay base including a top side. The base can define a handle receptacle, for instance at a first end of the base. The handle receptacle can include a handle capture section optionally having a tapered profile. A centrally located elongated guide can extend longitudinally along the top side of the base to guide translational movement of the ultrasound probe holder along a longitudinal axis of the base. A handle can be configured to be attached and detached, by a user, with the handle receptacle of the base. The handle can define a channel optionally having a wedge profile. The wedge profile of the handle can correspond to the tapered profile of the handle receptacle. Engagement of the channel to the capture section of the handle receptacle can attach the handle to the base.

Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.