A method of performing a transperineal biopsy procedure including the steps of: inserting an access needle into one of a plurality of needle receiving ports of a displacement member of a transperineal biopsy guide that is secured to the transrectal ultrasound probe; securing the access needle to the displacement member such that a position of the access needle relative to the displacement member is maintained; imaging the prostate of the patient with the transrectal ultrasound probe; inserting the access needle into the perineal access site of the patient; and inserting the biopsy needle through the access needle and into the prostate of the patient.

Systems, methods, and devices are provided for assisting or performing guided interventional procedures using custom templates. The system uses pre-procedure scans of a patient's anatomy to identify targets and critical structures. A template is then manufactured containing guide elements. During a procedure, the template may be aligned to the patient and instruments passed though the guide elements and into various targets. The template may be aligned using one or more of, for example, a position sensing system or a live imaging modality to register the patient to the template. The system makes optional use of devices designed to immobilize or track an organ during therapy.

An ultrasound imaging system includes a biplane ultrasound probe and a console. The biplane ultrasound probe includes a sagittal array and a transverse array. The console includes a transmit circuit, a receive circuit, and an image generator. The transmit circuit is configured to control the sagittal and transverse arrays to emit ultrasound signals while the probe is manually rotated and translated. The receive circuit is configured to receive electrical signal produced by the sagittal and transverse arrays in response to the sagittal and transverse arrays receiving echoes produced in response to the corresponding ultrasound signals interreacting with structure. The image generator is configured to construct a three-dimensional image with the electrical signals from the sagittal or transverse array using the electrical signals from both the sagittal and transverse arrays to track the motion of the probe and align scanplanes.

A needle guide for an angled ultrasound probe having a port tower with a plurality of needle ports aligned with an angled ultrasonic imaging plane. The needle ports in a port tower are aligned at the offset angle of the angled ultrasound probe and can support and guide a needle at the offset angle. Adjustment of the port tower along the transducer axis of the angled ultrasound probe maintains the alignment of the needle ports relative to the ultrasonic imaging plane and provides adjustment to accommodate differently sized patients. A method is also provided to securely align a needle with an angled ultrasonic imaging plane with an angled ultrasound probe such that the needle can accurately transect the ultrasound imaging plane.

A device includes an ultrasound probe including an elongated neck insertable in a patient and rotatable around a first longitudinal axis, an ultrasound transducer, and an elongated body rotatable around a second longitudinal axis that is parallel to and offset from the first longitudinal axis. The elongated body is removably attached to a probe mounting structure. A shaft is attached to the probe mounting structure, where rotation of the shaft causes corresponding rotation of the probe mounting structure and the attached elongated body of the ultrasound probe. The shaft defines a longitudinal shaft channel in an interior portion and a longitudinal shaft groove extending from a surface of the shaft to the longitudinal shaft channel. A cable is insertable into the longitudinal shaft channel through the longitudinal shaft groove, and enters an internal channel of the ultrasound probe through the longitudinal shaft channel enabling electrical connection with the ultrasound transducer.

Disclosed are various embodiments for a guidance and tracking system that facilitate templated and targeted biopsy and/or treatment. A guidance and tracking system may include a catheter having a six-degree-of-freedom magnetic tracking sensor, where the catheter can be positioned and anchored in an organ or a natural passage of an organ such as the urethral passage in the prostate of a patient. Using tracking sensors, a computing device may be employed to track a location and orientation of an organ and medical instruments during a treatment or diagnostic procedure. The computing device may determine a position and orientation of the medical instrument relative to the organ of interest. A graphical user interface including real, three-dimensional objects to overlay and adjust biopsy templates onto a real three-dimensional organ or lesion that is manually reconstructed prior to the biopsy procedure. A simulator or simulator mode can be provided for training.

Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

A method of performing a transperineal biopsy procedure includes imaging the prostate with a transrectal ultrasound probe with a transperineal biopsy guide coupled to the probe. The transperineal biopsy guide including a mount coupled to the probe, a guide member coupled to the mount and including a rail receiving channel extending a first length, and a displacement member including a rail member extending a second length between a proximal end and a distal end, and a vertically extending member coupled to the distal end of the rail member. The vertically extending member including a plurality of needle receiving ports. The method further includes sliding the rail member within the rail receiving channel. The method further includes inserting an access needle into the perineal access site of the patient and inserting a needle through the access needle and into a first location of the prostate of the patient.

A system for tracking an instrument includes two or more sensors (22) disposed along a length of an instrument and being spaced apart from adjacent sensors. An interpretation module (45) is configured to select and update an image slice from a three-dimensional image volume in accordance with positions of the two or more sensors. The three-dimensional image volume includes the positions two or more sensors with respect to a target in the volume. An image processing module (48) is configured to generate an overlay (80) indicating reference positions in the image slice. The reference positions include the positions of the two or more sensors and relative offsets from the image slice in a display to provide feedback for positioning and orienting the instrument.

A method of performing a therapy on a prostate of a patient via transperineal access. The therapy uses an ultrasound probe. The method includes positioning a pair of stabilization members of a needle guide adjacent the perineum. The pair of stabilization members spaced apart from each other and supporting a platform configured to slide along a portion of a length of the pair of stabilization members. The needle guide is coupled to the ultrasound probe. The method further includes coupling an access needle to the platform, and sliding the platform and the access needle relative to the pair of stabilization members and the ultrasound probe so the access needle extends into the perineum. And the method further includes, using the access needle as a conduit, injecting a radiation blocking substance between the rectum and the prostate.