A system for generating data relating to a tissue core comprises a core needle biopsy module configured to obtain a tissue core from a locus within the body, and a tissue disintegration module operably connected to the core needle biopsy module and configured to receive a tissue core from the core needle biopsy module and convert at least a portion of the tissue core into gaseous tissue molecules. The system also comprises first vacuum pump means configured to convey a tissue core from the needle biopsy module to the tissue disintegration module, and second vacuum pump means configured to convey gaseous tissue molecules from the tissue disintegration module to an analyser module.

The invention relates to the field of medical equipment, more specifically to syringes, and can be used for procedures of aspiration of various fluids, for fine needle biopsy, for puncture morphological diagnostics, and for injections of liquid medicinal products. The subject matter of the invention: the disclosed device, including a barrel with a tip for attaching a needle at one end, a piston with a stem slidingly mounted inside the barrel, and a grip at the end of the stem, according to the invention, is provided with a handle moveably coupled to the stem grip and rotatable in relation to a hinge unit located on the stem grip, wherein the handle is at least formed as a bracket with a reverse grip located at the end opposite to the handle attachment and having a slot arranged in the middle portion and intended for enclosing the stem on two sides.

Even when an insertion object is inserted to a deep position of a subject or even when the insertion object is inserted into the subject at an angle close to a right angle, it is possible to confirm the position of the insertion object in a photoacoustic image. The insertion object is, for example, a hollow puncture needle 15 that includes an opening at a tip thereof. The puncture needle 15 includes a light guide member 152 that guides light emitted from a first light source to the vicinity of the opening, and a light emitting portion 153 that is provided in the vicinity of the opening and emits the light. First photoacoustic waves, which are caused by the light emitted from the light emitting portion 153, are generated in the puncture needle 15. A first photoacoustic image is generated on the basis of the first photoacoustic waves.

A biopsy system includes a biopsy device, a control module, and a tissue transport tube. The biopsy device includes a probe, a needle, a cutter, and a transport valve. The needle extends distally from the probe. The cutter is movable relative to the needle and defines a cutter lumen. The holster is configured to couple to the probe. The transport valve is in communication with the cutter lumen. The control module is in communication with the biopsy device and includes a sample management assembly configured to receive one or more tissue samples severed by the cutter. The transport tube extends between the sample management assembly and the biopsy device. The transport tube is in communication with the transport valve such that the transport tube is configured to receive the one or more tissue samples severed by the cutter.

Microneedle (100, 200, 300, 720) comprising an elongated body (110, 210, 310) extending along a longitudinal axis from a top end to a bottom end on a substrate (300, 710), where the elongated body comprises an upper portion (120, 220, 320) and a lower portion (130, 230, 330). The lower portion (130, 230, 330) comprises an internal capillary bore hole (260, 730) extending into the substrate (300, 710). The upper portion (120, 220, 320) of the elongated body (110, 210, 310) has a semi-enclosed internal void space (140, 240) formed by at least three body sides whereof two body sides join at a sharp edge and a third body side is provided with an opening slit (150, 250, 350) extending from the lower portion (130, 230, 330) of the elongated body (110, 210, 310) to the upper end of the third body side. The top end of the elongated body (110, 210, 310) is configured as a bevel to create a sharp tip at the top of said edge, said bevel extending to the third body side. The semi-enclosed internal void space (140, 240) of the upper portion opening to the internal capillary bore hole of the bottom end of the elongated body (110, 210, 310), and the bottom end of the elongated body is connected to the substrate (300, 710).

The invention relates to a surgical instrument for separating and removing a biopsy. A suction channel for suctioning the biopsy out of a distal region in the direction of a proximal region is formed in a shaft, and/or a cutting tool is formed in one distal region or the distal region of the shaft, said cutting tool having a stationary cutting part and a counter cutting part which can be adjusted relative to the stationary cutting part about a rotational axis formed by a rotary joint wherein the cross-section of the suction channel expands in the suction direction from the distal region to the proximal region and/or the rotary joint is formed by two securing elements, each securing element being introduced from the interior to the exterior.

Methods and devices obtain cellular-component, e.g., proteins, RNA, DNA, metabolites, and combinations of these, from a solid tissue in-vivo using electroporation, and subsequently profile such tissue either inside or outside the subject's body. A method for determining if a solid tissue of a subject includes a benign or malignant tumor, or if a space occupying lesion (SOL) within the solid tissue is malignant or benign, includes placing at least one electroporation-electrode within the solid tissue, or within the SOL or in proximity thereto; applying pulsed electric field (PEF) via the at least one electroporation-electrode to thereby induce permeabilization of cells of the solid tissue or the SOL, and consequently release of at least one cellular-component therefrom to an extracellular matrix between and surrounding the cells; extracting the at least one cellular-component from the extracellular matrix.

A biopsy device includes a cylindrical hollow stylet having a proximal end, a distal end, and a uniform wall thickness. The proximal end and the distal end are disposed on the longitudinal axis. A longitudinal recess forms a sample chamber and is positioned adjacent the distal end of the cylindrical hollow stylet. A longitudinal insert has a longitudinal length, a distal terminal end, and an elongate channel. The longitudinal insert is positioned within the cylindrical hollow stylet with the distal terminal end proximal to the longitudinal recess. The longitudinal insert is immovably connected to the cylindrical hollow stylet. The elongate channel is configured to maintain a fluid passageway through the cylindrical hollow stylet from the proximal end to the longitudinal recess.

A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.

The present invention relates to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.