Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, a mucosal resection device. Systems include a combination of one or more of such instruments with or without injectable agents. Embodiments of various methods for performing the procedures are also provided.

A biopsy and aspiration device that can include an outer cannula that has a plurality of apertures formed in an outer surface, a biopsy stylet insertable into the outer cannula having a beveled tip portion and slits formed in the main body, and an aspiration stylet also separately insertable into the outer cannula having a plurality of apertures formed in the main body and an optional sealing element associated therewith. One or more of the apertures of the aspiration stylet can be aligned with one or more of the apertures of the outer cannula.

A needle for extraction of biological material from a fluid filled intracorporeal sac, the needle comprising: a shaft comprising a first flow channel comprising an inlet for aspirating biological material from the intracorporeal sac and a second flow channel comprising an outlet for supplying a flushing fluid to the intracorporeal sac; and wherein the outlet is configured to direct the flushing fluid in a direction substantially transverse to the first flow channel; and methods using the needle.

A plug delivery system and method of use. The plug delivery device includes a support leg, a plunger, and an extractor. The support leg includes an internal receiving space configured to receive an implanted coaxial needle assembly through an opening in the distal end. The plunger extends at least partially through the internal receiving space of the support leg and has a longitudinally adjustable relation with respect to the support leg. The extractor is also configured to translate in a longitudinal direction with respect to the support leg and has a needle connection component configured to engage the coaxial needle assembly. The extractor can be moved distally in the longitudinal direction to engage the coaxial needle assembly and then moved distally to concurrently retract the coaxial needle assembly while the plunger remains relatively stationary to deploy the sealant plug residing in the coaxial needle assembly.

A disposable medical vacuum drainage bag includes a flexible enclosure made of a flexible material. The flexible enclosure is configured to define an interior chamber. The flexible enclosure has a first fluid port and a second fluid port. The flexible enclosure has a collapsed state and an expanded state. A framework is located in the interior chamber. The framework has a plurality of frame structures configured to rotate in unison about separate rotational axes between a collapsed configuration and an expanded configuration, wherein the collapsed configuration facilitates the collapsed state of the flexible enclosure and the expanded configuration facilitates the expanded state of the flexible enclosure. An actuator is coupled to the framework. The actuator is configured to rotatably transition the plurality of frame structures between the collapsed configuration and the expanded configuration.

A handle for a medical device includes a proximal segment defining a proximal lumen extending therethrough and sized and shaped to receive an endoscopic medical device therein. A medial segment is received within a distal portion of the proximal segment and has an outer diameter smaller than an inner diameter thereof. A medial lumen extends through the proximal segment and is open to the proximal lumen. A distal segment is received within a distal portion of the medial segment and defines a distal lumen extending therethrough open to the medial lumen. The distal segment has an outer diameter smaller than an inner diameter of the medial segment. The medial segment includes a first movement limiting mechanism limiting movement of an endoscopic medical device inserted therethrough along an axis of the distal lumen and a second movement limiting mechanism limiting advancement of an endoscope attached to the distal body portion.

A device for performing surgical procedures, such as intracardiac procedures or neurosurgical procedures, includes a solid optical window formed of a transparent, compliant material, wherein the solid optical window includes a proximal side and a distal side, wherein a distal face of the solid optical window is configured to approach tissue during a surgical procedure; an imaging system embedded into the solid optical window and positioned to obtain an image through at least a portion of the distal face of the solid optical window; and a tool channel formed through the solid optical window from the proximal side to the distal side of the solid optical window, wherein the tool channel is configured to receive a tool for performing the surgical procedure.

A system for performing a minimally invasive procedure comprises a flexible catheter with a lumen extending therethrough. The system also comprises an elongate instrument sized for passage through the lumen and an optical coherence tomographic sensor coupled to the elongate instrument. The system also comprises a control system that includes one or more processors. The control system is configured to receive sensor data from the optical coherence tomographic sensor, profile a tissue based on the received sensor data, generate an output signal based on the profiled tissue, and based on receipt of the output signal, determine a distance between the elongate instrument and the profiled tissue.

A cartilage repair technique employs a cutter-tissue trap combination device to harvest cartilage tissue from a low-weight-bearing site of a subject. Cut tissue is aspirated though a lumen of a tissue cutter. The lumen includes an outer shaft having a first distal window and an inner shaft having a second distal window. Edges of the first distal window and the second distal window cooperate to provide a cutting action there-between upon rotation of the inner shaft within the outer shaft. A tissue trap coupled to the tissue cutter is configured to collect tissue shavings of a desired size to efficiently deliver the collected shavings to a repair site during surgery. The tissue trap includes a filter in a housing configured between a removable inflow chamber and a removable outflow chamber.

A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.