A medical device for sealing a defect in a body includes a wire frame that includes a plurality of wires that form a first occluding member and a second occluding member. In some embodiments, a sealing member is in contact with the wire frame. In some embodiments, the sealing member is configured to define one or more openings in the sealing member.

Transcatheter heart valve delivery systems having a tip assembly configured to close the hole or perforation made in a patient's septal wall after transseptal delivery of a stented prosthetic heart valve to a defective heart valve (e.g., a mitral valve). The delivery device is configured to permit in vivo release of the tip assembly immediately after deployment of the stented prosthetic heart valve to implant the tip assembly into the septal wall proximate the hole through which the stented prosthetic heart valve is delivered. Methods of treating the defective heart valve, including closing the hole made during transseptal delivery of the stented prosthetic heart valve with the tip assembly of the delivery device are also disclosed.

The invention relates to an occluder for closing the left atrial appendage of a patient, a system having a catheter and an occluder, and a method for providing the system, the occluder having a self-expandable frame, wherein a biological tissue is arranged on the frame on the outside thereof, which tissue covers said frame at least in part, wherein the biological tissue is stabilized by treatment by means of a reticulation method and, in order to make it durable, is wetted with a liquid medium or dried.

A left atrial appendage closure apparatus for obstructing the left atrial appendage, comprises a sealing plate and an anchor plate. The sealing plate is a mesh structure and arranged with a choke membrane inside. In addition, the sealing plate adopts a tubular member for distal fixation and is connected with the anchor plate by the tubular member. The proximal end of the sealing plate is fixed with a fastener and is provided with a structure to connect to a convey device. The end of the tubular member at the other side away from the end connected to the sealing plate is arranged with a plurality of supporting rods, which intersect radially to form the anchor plate.

A medical device for treating an LAA is presented. The device includes a cap, a bulb and a joint assembly therebetween. The cap is a three layer mesh structure with a retaining hub securing the layers together. A plurality of proximal wire loops extend from the base layer to a proximal post of the joint assembly. The bulb has a plurality of distal wire loops that extend between a terminal post and a distal post of the joint assembly. The joint assembly comprises a first ball joint, a second ball joint and a housing. Each ball joint is retained in the housing independent ball and socket relationships. Each ball joint and post defines a longitudinal axis. The housing defines a housing longitudinal axis. By way of the ball and socket relationship each ball joint longitudinal axis may form an angle of between about 0 to about 35 degrees with the housing longitudinal axis in any direction.

Disclosed herein are embodiments of a method of treating a tissue of the heart, for example and without limitation, a tissue of the left atrial appendage, including twisting at least a portion of a tissue of the left atrial appendage to constrict an ostium of the left atrial appendage, and ablating at least a portion of the tissue of the heart, which can include a tissue of the left atrial appendage, the ostium of the left atrial appendage, and/or at least a portion of a tissue adjacent to the ostium of the left atrial appendage.

A method for reducing left ventricular volume, which comprises identifying infarcted tissue during open chest surgery; reducing left ventricle volume while preserving the ventricular apex; and realigning the ventricular apex, such that the realigning step comprises closing the lower or apical portion of said ventricle to achieve appropriate functional contractile geometry of said ventricle in a dyskinetic ventricle of a heart.

A device includes a plurality of elongate members, an occlusive component, and a support component. The occlusive component includes a plurality of first features each defined by a first portion of a respective elongate member. The support component includes a plurality of second features each defined by a second portion of the respective elongate member. A first termination element is defined by proximal end portions of the plurality of elongate members and located near a proximal end of the device, and a second termination element is defined by distal end portions of the plurality of elongate members and located near a distal end of the device. One or more anchor elements include a frame attachment portion and an anchor portion, the frame attachment portion including a first portion of a fixation elongate element wrapped around an elongate member, and the anchor portion including an anchor feature.

Various aspects of the present disclosure are directed toward apparatuses, methods, and systems as relating to occlusion. In certain instances, the apparatuses, methods, and systems may include a device for placement in vessels, appendages, and openings in a body. The device may include a unitary frame having a face portion that includes a center frame portion a plurality of elongate members.

The present disclosure describes a system and method for securing medical devices to the tissue of a patient using one or more anchors. Anchors can be independent from or integral to the medical device deployed within the patient. Such anchors are configured to engage and maintain contact with the tissue using a tissue-penetrating point and bendable shaft.