A medical implant including an expandable framework configured to shift between a collapsed configuration and an expanded configuration, the expandable framework comprising a plurality of interconnected struts defining a plurality of cells; and an occlusive element connected to the expandable framework and having an inner surface and an outer surface. The expandable framework may include a plurality of securement members projecting from the plurality of interconnected struts. One of the inner surface or the outer surface of the occlusive element may be in contact with the plurality of interconnected struts, and the other of the inner surface and the outer surface not in contact with the plurality of interconnected struts may lie against an opposing surface of each of the plurality of securement members. A tip portion of the plurality of securement members may not extend radially outward of the plurality of interconnected struts.

A device for permanent placement across an atrial appendage ostium in a patient includes a support structure having a contracted delivery configuration and an expanded deployed configuration defining a radially enlarged portion to permanently engage an interior wall of the atrial appendage, a membrane attached to the support structure and configured to extend across the ostium of the atrial appendage when the support structure is in the expanded deployed configuration, and a polymer coating disposed on at least one of the support structure and the membrane, the polymer coating including a direct oral anticoagulant (DOAC) dispersed in a polymer.

A bristle device for delivery into a body lumen comprises a longitudinally extending stem 1 and a plurality of bristles extending generally outwardly from the stem for anchoring the device in a body lumen. There may be at least two bristle segments and in some cases there are flexible sections between the segments. The flexible sections articulate to enable the device to pass through a catheter placed in a tortuous anatomy or to be deployed in a curved vessel, or across a bifurcation. In some cases at least some of the bristle segments are spaced-apart to accommodate bending of the bristles.

A device for regulating blood pressure between a patient's left atrium and right atrium, and apparatus for delivery the device, are provided. The delivery apparatus may include one or more latching legs, a release ring, a pull chord, and a catheter wherein the latching legs are configured to engage the device for delivery. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a medical device coupled to a delivery catheter includes a fluid flow path that facilitates contrast fluid to pass through the delivery catheter and the medical device to a distal side thereof to provide imaging information as to the position of the medical device positioned in the opening, such as the left atrial appendage. In another embodiment, a medical device is coupled to a delivery catheter, the medical device including flaps adjacent a hub of the medical device that close-off a bore of the hub upon the catheter being detached from the medical device.

A left atrial appendage occluder for improving sealing effect and a manufacturing method thereof are provided. The left atrial appendage occluder includes a sealing portion and an anchoring portion coupled to the sealing portion. The sealing portion and the anchoring portion abut against each other. A tight connection between the sealing portion and the anchoring portion can be achieved by applying a pre-tightening force, such that the left atrial appendage occluder can be better attached to and occlude the left atrial appendage after being release.

The present invention describes systems and methods for treating a hole in the septum, such as a patent foramen ovale or an atrial septal defect, with a closure implant designed to fluidly seal the hole to prevent blood from flowing between the right atrium to the left atrium. The closure implant includes two structures positioned on opposite sides of the hole in septum configured to close and seal the hole. The first structure is an expandable petal anchor having multiple petal groups with multiple petals of different sizes and/or shapes made of shape memory wire configured to be positioned on a distal side of the hole in the septum wall, and the second structure is a braided disk made of shape memory mesh positioned the proximal side of the hole in the septum wall, opposite the petal anchor. The braided disk is sized to cover the hole once it is expanded. The petal anchor is designed to pull and compress the braided disk against the septum wall to cover and fluidly seal the hole. The closure implant is designed to be delivered to the heart using a catheter-based delivery system.

The present disclosure provides a catheter assembly including a catheter tube and an expandable unit attached to the catheter tube. The expandable unit is configurable in a collapsed configuration for facilitating delivery of the catheter assembly through a body lumen and a fully expanded configuration for contacting an interior wall of the body lumen to cover a perforation. The expandable unit defines a longitudinal channel extending from a proximal end to a distal end of the expandable unit when in the fully expanded configuration, permitting blood flow past the expandable unit. The disclosure further provides a method of treating a perforation by delivering a catheter assembly with an expandable unit to a perforation site, expanding the expandable unit to contact an interior wall of a body lumen to cover the perforation, and permitting blood flow past the expandable unit while in contact with the interior wall covering the perforation.

An occluder device is provided for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue, the device including a compliant balloon defining a fluid-tight balloon chamber and a balloon channel forming a longitudinal passage from a proximal to a distal side of the balloon, the balloon including a fluid port for filling a fluid into the balloon chamber. A tip and a base are coupled to the distal and the proximal sides of the balloon, respectively. At least one connecting strut is attached to the tip and to the base. An elongate actuator is disposed longitudinally slidable in the balloon channel and connected to the tip, and longitudinally slidable with respect to the base so as to set a distance between the tip and the base. A lock is configured to maintain the distance between the tip and the base. Other embodiments are also described.

A surgical pad can comprise a flexible pad portion configured to be positioned over an opening in a target tissue. A plurality of elongate ribs can be distributed across a surface of the flexible pad portion oriented away from the target tissue and can be coupled to the flexible pad portion. A surgical pad can comprise a central opening configured to be aligned with an opening in a target tissue, and a plurality of edge openings distributed around an outer edge portion. A method can comprise positioning a spacer between a target tissue and a surgical pad to adjust the tension of surgical cords secured to surgical pad. A method can comprise positioning a spacer between a surface of a surgical pad oriented away from a target tissue and portions of surgical cords secured over the surface of the surgical pad, to adjust the tension of the surgical cords.