The invention relates to a device for treating blood flow in an internal wound, including a handling member connected to a series of successively narrower tubes, each tube including a liquid-expandable article. The tubes can be pivotably connected to each other, allowing the tubes to conform to the contours of the wound, or fixed together. The tubes can be encased in a liquid-soluble layer that keeps the liquid-expandable article sequestered from liquids.

The stepwise-tapering profile of the device allows for its insertion into the internal wound with little or no resistance until fully seated. Upon encountering liquids within the wound, the liquid-soluble layer can dissolve to expose the liquid-expandable article. When exposed to the wound liquids, the liquid-expandable element can expand in volume, providing compressive pressure against internal wound surfaces and minimizing blood loss.

The tubes and the liquid-expandable element can include therapeutic agents for treating the wound.

Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and/or slowed.

A method for the use of a composite plug for arteriotomy closure which includes an elongate core member and one or more layers disposed at least in part about the elongate core member. The composite plug may include an outer member at least partially surrounding the elongate core member. The method of use of the composite plug results in a progression of radial swelling along the longitudinal axis of the composite plug.

Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy.

A septal closure and port device for implantation in the atrial septum of a patient's heart comprises an expandable frame can comprise a central portion defining a lumen, and first and second opposing end portions. The frame is configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can further comprise a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member is configured to permit a medical instrument inserted through the lumen and into the left atrium, such as for performing a subsequent medical procedure in the left side of the heart.

Devices and methods for assisting cardiac function. In an exemplary embodiment of a device for assisting heart function of the present disclosure, the device comprises a first plate and an opposing second plate, each plate having an inner surface, a cardiac processor coupled to at least one of the first plate and the second plate, a bladder having an inner chamber and disposed between the inner surfaces, and a first catheter having a proximal end in communication with the inner chamber of the bladder and a distal end having a first pericardial balloon coupled thereto, wherein a gas and/or a liquid within the inner chamber of the bladder can be injected into the first pericardial balloon upon compression of the first plate relative to the second plate, and wherein the gas and/or the liquid can be removed from the first pericardial balloon upon retraction of the first plate relative to the second plate.

Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region.

Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a membrane with a plurality of inflatable elements. The membrane may include a valve disposed in a central region of the membrane with a plurality of inflation channels extending radially from the valve. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating the plurality of inflatable elements on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region.

An occluder device includes a core form having first and second axial ends, a first plurality of wires emanating radially from the first axial end of the core form, the first plurality of wires being configured to circumferentially wrap around an axis of the core form, a first covering coupled to at least one of the first plurality of wires or the first axial end of the core form, a second plurality of wires emanating radially from the second axial end of the core form, the second plurality of wires being configured to circumferentially wrap around the axis of the core form, and a second covering coupled to at least one of the second plurality of wires or the second axial end of the core form.

An example occlusive implant is disclosed. The example occlusive implant includes a framework including a projection and a cushioning member coupled to the framework, the cushioning member including a first end region and a second end region opposite the first end region. Additionally, the first end region is coupled to the projection, the second end region is coupled to the framework and the cushioning member includes a curved portion designed to minimize trauma to a target site.