A system to facilitate sealing a puncture of a vessel includes an implant having first and second expandable sections, and a delivery device that includes an inner tube and a circumscribing outer tube. The outer tube defines a first lumen configured to retain the implant, and a second lumen configured to channel fluid from the vessel through a distal opening proximal to the implant. A pusher circumscribed at least partially by the outer tube is configured to compress the implant to selectively expand the first and second expandable sections. The outer tube is selectively retractable relative to the inner tube such that the first expandable section remains substantially within the first lumen and the second expandable section is positioned outside of the first lumen. The outer tube is further selectively retractable relative to the inner tube such that the first expandable section is positioned outside of the first lumen.

Expandable occlusive plugs and methods of using them are disclosed. The devices generally include a tubular body bearing multiple slits defining leaves, which expand radially outward when the ends of the device are brought toward one another.

A medical device for treating a PFO is presented as well as a mechanism for its delivery, repositioning and/or removal. The device includes a wire or cable framework of six shape-memory cables formed into a right side having six loops that support a right side sail and a left side having six loops that support a left side sail. The right side loops and left side loops are connected together via waist members that extend between the right side and left side loops. Each cable is threaded through a through hole of a central post and pass through one of each of four types of connecting collars that establish the basic shape of the PFO device and retain the cables together to form a flexible and resilient PFO device.

The device for closing openings or cavities in blood vessels, e.g. in veins or in the heart, said device comprises a closing body comprising an outer side having a partial region arranged for blood flow therealong at least in a part of said partial region thereof when said closing body is in its state of use for closing said opening or cavity. Furthermore, the device comprises at least one layer (16) of biostable nonwoven fiber material, which at least within a partial surface of said partial region of said outer side of the closing body is at least partially in abutment on the closing body.

There are shown and described embodiments of a closure device for closing holes in tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Disclosed is a biomedical device being introduced by a hollow tube having a longitudinal axis in a subject in a minimally invasive surgery procedure for watertight sealing of an opening including at least two assemblies, each assembly including one flap connected to one arm, the arm having an longitudinal axis; the assemblies including a delivery configuration, a deployed configuration, and a sealed configuration and outwards deployment unit for switching from the delivery configuration to the deployed configuration and inwards deployment unit for switching from the deployed configuration to the sealed configuration. Also disclosed is a kit of parts including an outer hollow tube, an inner hollow tube, and a related biomedical device.

Devices and methods for occluding or promoting fluid flow through openings are disclosed. In one exemplary embodiment an occlusion device is provided having an expandable outer elongate tubular body, a guide member extending from a distal end of the outer body, and a slide tube disposed within the outer body, the proximal portions of the outer body and the slide tube being fixedly mated. The slide tube is configured to slide distally within the outer tubular body when the tubular body is expanded to form wings. A tether can be included as part of the device and it can be used to assist in positioning and locking a location of the device in an opening. Exemplary methods for delivering devices disclosed herein are also provided.

The present disclosure provides embodiments of a method for improving coaptation of the anterior and posterior mitral valve leaflets by applying a remodeling force to the posterior leaflet. In particular embodiments, a tension member is secured at a location on or proximate to the posterior leaflet. Tension can be applied to the tension member in a direction superiorly and anteriorly toward the interatrial septum. The tension member can be secured at a location proximate the septum to maintain the tension. The tension provides the remodeling force, pulling the posterior leaflet superiorly and anteriorly to improve coaptation with the anterior leaflet.

An occlusion device and a production process for it are described. The occlusion device consists of a mesh or braiding of at least one wire or thread wherein the occlusion device has been given a suitable design using a reshaping and/or heat-treatment process, is self-expandable, and is configured for secure anchoring in an atrial appendage of the left or right atrium of a heart. The occlusion device comprises a proximal retention region on a proximal end of the occlusion device a distal retention region and a central region between the proximal retention region and said distal retention region and wherein the occlusion device has a closed distal end without a holder, and wherein the occlusion device is at least partly of essentially spherical form, and hollow.