A mechanical locking assembly for an endovascular device, comprising a shaft comprising a main body a shaft comprising a main body and enlarged end, an inner channel component comprising a full collar formed on proximal end of the inner channel component, and an outer cage component comprising a partial collar formed on the outer cage component wherein the full collar of the inner channel component fully surrounds the outer cage component and the partial collar of the outer cage component at least partially surrounds the shaft.

A closure device system for sealing a percutaneous puncture in a vessel wall can comprise a toggle configured to engage an interior surface of the vessel wall, a plug configured to engage an exterior surface of the vessel wall, and a suture that extends through the plug and through the toggle along at least a first direction so as to couple the toggle to the plug. The system can further comprise a tube that extends through the plug and through the toggle along the first direction such that a distal end of the tube is disposed distally to the toggle. The tube can define a guidewire lumen that extends therethrough along the first direction. And the guidewire lumen can be configured to receive a guidewire that protrudes from the vessel wall such that the plug, toggle, and tube are slidable along the guidewire toward the vessel wall.

A method for closing a puncture in tissue that includes advancing a guide member into proximity with the tissue, the guide member having a needle guide, positioning a distal end of the guide member with the needle guide toward the tissue to present an opening of the needle guide toward the tissue the needle guide cooperating with a suture securing device that is slidably coupled to the guide member and a suture attached to the suture securing device, deploying the suture securing device, the suture securing device comprising a body with an anchor point for the suture and features that allow the suture securing device to pierce the tissue and resist retraction through the tissue, and establishing tension in the suture to move the suture securing device toward another suture securing device to thereby close the puncture in the tissue.

A closure device system for sealing a percutaneous puncture in a vessel wall can include a toggle configured to engage an interior surface of the vessel wall, a plug configured to engage an exterior surface of the vessel wall, and a suture that extends through the plug and through the toggle along at least a first direction so as to couple the toggle to the plug. The system can further include a tube that extends through the plug and through the toggle along the first direction such that a distal end of the tube is disposed distally to the toggle. The tube can define a guidewire lumen that extends therethrough along the first direction. And the guidewire lumen can be configured to receive a guidewire that protrudes from the vessel wall such that the plug, toggle, and tube are slidable along the guidewire toward the vessel wall.

The invention relates to medical implant (1) that is adapted to close a defect (D) or a cavity, preferably a defect in an atrial or septal wall (W) or a left atrial appendage. The implant (1) comprises an occlusion device (6) and has two states. It is adapted to, in a first state, be deployed to a defect site (D), where it can be brought into a second state by an activation mechanism. It is adapted to close said defect (D) in said second state.

The present invention relates generally to a closure system for use in surgical procedures.

The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. In some embodiments, the occluder is formed from filaments that are joined together to define a substantially cylindrical form with openings defining struts. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is engaged so that the occluder closes the aperture.

A method and device for positioning an expandable support in a blood vessel is disclosed herein. The device may include a handle, a catheter assembly, a core wire, and an expandable support. The expandable support may be used to position the device relative to the arteriotomy, as well as to provide temporary hemostasis. The expandable support may be attached to the catheter assembly at a first end, and to the core wire at a second end to optimize the width of the expandable support based on the function being performed by the expandable support at a given time. The catheter assembly may be able to move relative to the handle and the core wire, thereby moving the first end of the expandable support relative to the handle and the core wire.

Transcatheter heart valve delivery systems having a tip assembly configured to close the hole or perforation made in a patient's septal wall after transseptal delivery of a stented prosthetic heart valve to a defective heart valve (e.g., a mitral valve). The delivery device is configured to permit in vivo release of the tip assembly immediately after deployment of the stented prosthetic heart valve to implant the tip assembly into the septal wall proximate the hole through which the stented prosthetic heart valve is delivered. Methods of treating the defective heart valve, including closing the hole made during transseptal delivery of the stented prosthetic heart valve with the tip assembly of the delivery device are also disclosed.

An occlusion device or plug having a proximal plug section and a distal plug section. The plug sections may each be shifted between an unexpanded configuration and an expanded configuration at the deployment site to occlude the deployment site. A tubular member such as a silicone tube may be used to form an occlusion device or plug shiftable or expandable into a desired configuration. An intermediate section between a proximal plug section and a distal plug section may be configured to be manipulated at least to shift at least one of the plug sections from an expanded configuration to an unexpanded configuration. A pair of stents may be coupled together via an intermediate section in such manner such that manipulation of the intermediate section causes at least one of the stents to shift from an expanded configuration to an unexpanded configuration.