Systems and methods for sealing tissue sites may comprise coring tissue at a target site such that a tissue core is removed from the target site thereby creating a core cavity at the target site and causing sealing of at least a portion of the target site.

The present application discloses a device and methods for performing a vascular closure procedure that comprises inserting a sheath into a tissue tract defined in a body part and injecting a procoagulant material into the tissue tract adjacent a vascular access site via the sheath.

The present application discloses devices and methods for performing a vascular closure procedure that comprises inserting a sheath into a tissue tract defined in a body part, temporarily sealing a vascular access site, flushing the tissue tract with a flushing fluid via the sheath, dispensing a procoagulant material into the tissue tract adjacent the vascular access site via the sheath, and then unsealing the vascular access site to cause coagulation of blood adjacent the vascular access site.

A closure system for delivering a sealant to an arteriotomy. A distal section of the closure system can include overlapping inner and outer sleeves that can expand with expansion of the sealant. A proximal section of the closure system can include a handle portion and a sheath adapter extending from the handle portion. The handle portion can comprise one or more actuators that when depressed or engaged can assist in deployment of the sealant in the arteriotomy and can further include tamping of the sealant and/or retraction of an expandable member. The sheath adapter can removably engage a side port or an irrigation line of a standard procedural sheath. When the sheath adapter is secured to the procedural sheath, movement of the closure system can also move the procedural sheath.

A hemostatic device is provided with: a first tubular member; a positioning member having a first engagement section and engageable with an opening of a blood vessel; a hemostatic agent arranged further to a proximal end side than the first engagement section of the first positioning member; a push-out member making it possible to push the hemostatic agent out from a distal end section of the first tubular member when the push-out member is moved; a first operation unit for executing a first distal end operation for causing the first tubular member and the push-out member to move in a relative manner to a distal end side, and a second distal end operation for causing the push-out member to move in a relative manner to the distal end side; and a switching mechanism for restricting the second distal end operation until the first distal end operation is completed.

A method and prosthesis is provided for percutaneous repair of an anatomical defect, such as an inguinal hernia. The method involves percutaneously accessing the inguinal canal of a patient. Following hernia reduction, if required, the hernia defect may be accessed and repaired percutaneously from within the inguinal canal. An implantable prosthesis may be percutaneously delivered into the inguinal canal. The prosthesis may be advanced along the inguinal canal from the percutaneous entry location to the defect site, where it may be deployed over and/or within the defect. A biocompatible foam material may be percutaneously delivered into the inguinal canal to reduce and/or repair the hernia defect. The foam may fill and solidify in the canal to prevent abdominal viscera from reentering the canal. Ablative therapy may be performed within the inguinal canal to cause a fibrotic response resulting in scar tissue formation and/or tissue shrinkage that narrows the canal.

A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

Multiple vascular wall penetrations are formed and sealed in a single blood vessel, typically a vein, for performing cardiac and other catheter-based procedures. Access sheaths are placed in two or more tissue tracts each having a vascular wall penetration at a distal end and into a lumen of the blood vessel. A catheter is advanced though each of the access sheaths to perform a therapeutic or diagnostic procedure. A vascular closure device is introduced through each access sheath, typically sequentially, and an occlusion element at a distal end of the device is deployed against an inner wall of the blood vessel in a manner so that the adjacent access sheath does not interfere or overlap with the deployed occlusion element. The vascular penetration at the distal end in that tissue tract may then be sealed prior to using another vascular closure device to seal a caudally adjacent vascular wall penetration.

An apparatus for sealing a puncture through tissue having an introducer sheath therein includes an elongate positioning member including a housing on a proximal end and an expandable member on a distal end, and a cartridge advanceable along the positioning member from a proximal position to a distal position. The cartridge includes a tubular member including a sealant and an advancer member disposed within lumen of the tubular member. A sleeve is slidably disposed over the tubular member distal end such that, when the tubular member is advanced over the positioning member, the tubular member distal end enters the introducer sheath while the sleeve is stopped and slides over the tubular member to expose the tubular member distal end within the introducer sheath. The introducer sheath and cartridge are then withdrawn, exposing the sealant within the puncture.

A compression device includes: an adhesion surface configured to be adhered to a biological surface; and an inflatable portion configured to compress the biological surface. The inflatable portion defines an accommodation space capable of accommodating a fluid, and the inflatable portion is capable of being inflated in a thickness direction from a flat deflated form and being changed to an inflated form by supplying the fluid to the accommodation space. The inflatable portion is provided with an inflation restricting portion that is provided at a position sandwiched or surrounded by inflation regions inflatable in the thickness direction in a plan view viewed along the thickness direction, and in which inflation in the thickness direction is restricted by the inflation regions.