A system having an elongate assembly, an expandable assembly having a fixed end region and a movable end region, the expandable assembly selectively transitioning between an expanded state and an unexpanded state with movement of the movable end region towards the fixed end region, and an advancement aid extending distally from the expandable assembly.

A vessel access and closure assist system is used for accessing a vessel to perform a vascular intervention. The system facilitates the delivery of a vessel closure device onto a blood vessel for closing an opening in the wall of the blood vessel. The vessel access and closure assist system includes a procedural introducer sheath that directly couples to a vessel closure device delivery sheath such that the procedural introducer sheath does not have to be exchanged with the vessel closure device delivery sheath.

Device and method embodiments discussed herein are directed to mechanical closure of an access passage in a tissue layer adjacent to an access hole in a vessel such as an artery or vein of a patient. Some of these embodiments may also be applicable to direct closure of a vessel wall in some instances.

Devices for approximating multiple tissue edges internal to a body are disclosed.

Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include an endoscope and a backstop delivery device extendable through the endoscope. The backstop delivery device may deliver a backstop to a location of selected tissue for resection. A backstop may include a covering being deployable in a patient. The covering may have one or more anchoring mechanisms disposed on an edge of the covering. A tissue resecting device may be extendable through the endoscope for resecting the selected tissue for resection. The covering may be deployable to an outer surface of the body lumen, such that the anchoring mechanism may secure the covering to the outer surface of the body lumen and the covering may expand to cover the selected tissue for resection.

Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.

Devices for approximating multiple tissue edges internal to a body are disclosed.

Disclosed is a device (100) for treatment of anal fistula. The device comprises a hollow wire (110) comprising a first end (112) and a second end (114) opposite to the first end, the hollow wire is operable to be received by a fistula track with both first and second ends projecting out of the fistula track. The device also comprises an insert (120) operable to be partially inserted into the first end of the hollow wire and to project out of the first end. The device further comprises an applicator (130) operable to be removably arranged on the second end of the hollow wire when the hollow wire is placed in the fistula track. The applicator is operable to be held for enabling the projected out insert to be inserted into second end for detachably coupling the first and second ends to form a closed loop around the fistula track.

Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery. Embodiments of the systems and methods can be used in combination with embolic protection systems including blood flow reversal mechanisms, arterial filters, and arterial occlusion devices.

A vessel closure device delivery system including a delivery device that couples to a vessel closure clip for delivering the clip onto a blood vessel and a retractable vessel locator is removeably attached to the delivery device, the distal end of the vessel locator being adapted to transition from a collapsed state suitable for insertion into a vessel and an expanded state that lodges against a wall of the vessel from inside the vessel.