A handheld focused extracorporeal shock wave therapy (f-ESWT) device includes a plurality of piezoelectric elements, a power supply circuit, and a plurality of driver circuits. The piezoelectric elements are each configured to generate an individual shock wave. The power supply circuit is configured to output a first DC voltage and a second DC voltage. The first DC voltage greater than the second DC voltage. The driver circuits are each operably connected to the first DC voltage, the second DC voltage, and to a corresponding piezoelectric element of the plurality of piezoelectric elements. Each driver circuit includes a switching element electronically configurable in an open state and in a closed state. When the switching element is in the open state, the first DC voltage and the second DC voltage are applied to the corresponding piezoelectric element to pre-charge the corresponding piezoelectric element with a DC pre-charge voltage having a first polarity.

The present disclosure relates to plasma generation systems which utilize plasma for semiconductor processing. The plasma generation system disclosed herein employs a hybrid matching network. The plasma generation system includes a RF generator and a matching network. The matching network includes a first-stage to perform low-Q impedance transformations during high-speed variations in impedance. The matching network includes a second-stage to perform impedance matching for high-Q impedance transformations. The matching network further includes a sensor coupled to the first-stage and the second-stage to calculate the signals that are used to engage the first and second-stages. The matching network includes a first-stage network that is agile enough to tune each state in a modulated RF waveform and a second-stage network to tune a single state in a RF modulated waveform. The plasma generation system also includes a plasma chamber coupled to the matching network.

An apparatus for treating skin has a console with a user input device and a handpiece assembly. The handpiece assembly is configured to treat skin. A fluid line provides fluid communication between the console and the handpiece assembly. A manifold system is coupled to the console and controlled by the user input device. The manifold system is configured to hold releasably a plurality of fluid sources and deliver fluid from at least one of the plurality of fluid sources to the handpiece assembly.

A dermal treatment handpiece has a body with proximal and distal ends, a jet spray delivery head formed at the distal end of the body and connected to sources of a liquid suspension of a therapeutic agent and of a pressurized gas for a selectable combined supply thereof to the jet spray delivery head. The jet spray delivery head has a base formed at the distal end of the body, a localized environmental jet spray isolation chamber extending from the base to a distal exit port, a nozzle extending into the isolation chamber from the base, connected to a combined inflow of the liquid suspension and the pressurized gas, and one or more tubes mounted within the nozzle for receiving the combined inflow, each tube having a delivery tip extending into the isolation chamber for emitting a high pressure, high velocity jet spray along a delivery axis in response to receiving the combined inflow.

Disclosed herein are devices (e.g., needles (e.g., hollow needles), hollow staples, articles, apparatuses, and systems), kits, and methods for treating skin and skin conditions, for example, by promoting skin tightening, such as by reducing skin laxity and reducing tissue area or volume.

A dermatome blade assembly having at least two blades, each including a cutting edge, a rear edge spaced from the cutting edge, and two side edges joining the cutting edge and the rear edge. At least one of the blades has at least one throughgoing aperture, and a blade carrier including a main body extending in a transverse direction and means for connecting each of the at least two blades to the blade carrier. The blade carrier comprises a recess arranged to receive a drive pin of a dermatome such that oscillating motion of the drive pin causes reciprocating motion of the dermatome blade assembly.

The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning and/or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The present disclosure relates to plasma generation systems which utilize plasma for semiconductor processing. The plasma generation system disclosed herein employs a hybrid matching network. The plasma generation system includes a RF generator and a matching network. The matching network includes a first-stage to perform low-Q impedance transformations during high-speed variations in impedance. The matching network includes a second-stage to perform impedance matching for high-Q impedance transformations. The matching network further includes a sensor coupled to the first-stage and the second-stage to calculate the signals that are used to engage the first and second-stages. The matching network includes a first-stage network that is agile enough to tune each state in a modulated RF waveform and a second-stage network to tune a single state in a RF modulated waveform. The plasma generation system also includes a plasma chamber coupled to the matching network.

Disclosed are kits for at least partly liquefying tissue. The kit may include a liquefaction promoting medium (LPM). The LPM may include a non-ionic surfactant; a zwitterionic surfactant; and an abrasive material. The kit may include instructions. The instructions may direct a user to treat a tissue of a living subject by: applying the LPM together with the abrasive material to the tissue of the living subject; and transmitting energy to the tissue of the living subject through the abrasive material in the presence of the LPM effective to cause at least partial dissolution of one or more components of the tissue of the living subject.