Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.

A method for cosmetically treating skin tissue is disclosed in which a combination of laser energy and RF energy is applied to the skin tissue. In the method, a microchannel is first formed in the skin tissue having a length, a depth and a width by ablating the skin tissue. After that, RF electrodes are placed on the skin tissue on either side of the width dimension of the microchannel, followed by activation of RF energy to drive RF energy below the depth of the microchannel formed, and this the RF energy is driven deeper into the skin tissue than would have occurred in the absence of the microchannel.

Device for safely and precisely causing micro-injuries to the dermis to stimulate collagen production a skim remodeling. Specifically, needles on the device pierce the epidermis and basal cell layer into the dermis. The device incorporates safety features for the operator to be able to operate the device with one hand while keeping the other had free during procedures. Additionally, the device incorporates single use safety controls to help prevent cross contamination between patients.

Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.

The invention pertains to a device for resonance intracellular transport wherein said device can be connected to two electrodes, wherein a first of said electrodes is configured to contain an active principle to be administered by an intracellular route, the device comprising a wave generator configured to generate a driving signal to be sent to said electrodes, wherein said driving signal comprises a plurality of packets grouped in trains of packets and in groups of trains, wherein each packet consists of a unidirectional signal resulting from the combination of a modulating signal and a carrier signal, wherein each train of packets consists of a series of packets, wherein each group of trains comprises a series of trains of packets, and said wave generator is configured to reverse the polarity of said trains of packets, characterised in that the device is configured to generate a driving signal having a first depth frequency of the carrier signal correlated to the depth of an organ or of a tissue to be treated and at least a second depth frequency correlated to the thickness of the said organ or tissue, and to generate resonance frequencies expressed by the repetition frequency of the packets, by the repetition frequency of the trains of packets and by the repetition frequency of the groups of trains.

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.

Exemplary embodiments of method and apparatus are provided for resurfacing of skin that includes formation of a plurality of small holes, e.g., having widths less than about 1 mm or 0.5 mm, using a mechanical apparatus, thus avoiding generation of thermal damage as occurs with conventional laser resurfacing procedures and devices. The holes formed can be well-tolerated by the skin, and can exhibit shorter healing times and less swelling than conventional resurfacing procedures. The apparatus includes one or more needles adapted to remove a small portion of tissue when inserted into and withdrawn from the skin. The fractional surface coverage of the holes can be between about 0.1 and 0.7, or between about 0.2 and 0.5. The exemplary method and apparatus can produce cosmetic effects such as increases in collagen content, epidermal thickness, and dermal/epidermal junction undulations in the skin.

A system and method for cosmetic treatment of a region of a biological surface using cold atmospheric plasma is presented. In one embodiment, a method of treatment of a region of a biological surface with cold plasma includes: selecting a post-treatment formulation; and applying the post-treatment formulation to the region pre-treated by the cold plasma.

A system and method for treating a tissue is provided. The treatment causes a tightening or lifting of tissue. The method includes delivering a photochemical agent through a depth of the tissue to distribute the photochemical agent adjacent proteins within the tissue and irradiating the tissue with an electromagnetic irradiation at a wavelength that activates the photochemical agent, causing a protein response that brings fibers of the tissue closer together in order to one of reduce tissue laxity and tighten the tissue. A kit is provided to facilitate the method.