Stepper motor with a housing 1,2,4,6,16, in which a cylindrical rotor 11,15 fixed on a central shaft 12 can rotate but not translate along an axial direction. There are cylindrical translators 9, 14 on both sides of the rotors 11, 15, where the translators 9, 14 are sealed fit in a cylindrical space within the housing 6 and around the central shaft 12 and where the translators 9, 14 can only translate in an axial direction, where in one axial position of a translator 9, 14 a set of triangular asymmetric teeth 20 located on the translator 9, 14 can interact and fit into a set of triangular asymmetric teeth 21 on the rotor 11, 15, where the shape of the teeth 21 on both sides of the rotor 11, 15 is symmetric and where one of the sets of teeth 20, 21 between one translator 9 (14) and the rotor 11 (15) and a set of teeth 20, 21 between the other translator 9 (14) and the rotor 11 (15) are tangentially shifted, i.e. offset over a length equal to half the width of a tooth 20, 21 and where the translators 9, 14 can be moved by a pressure difference between the part of the cylindrical space between the housing 6 and a translator 9, 14 and the part of the cylindrical space between the translator 9, 14 and the rotor 11, 15.

A trajectory guiding apparatus and one or more methods associated therewith for facilitating precision-guided alignment and implantation of a DBS therapy device in a patient. A base plate and base frame combination provides a platform for a dual-stage slider (DSS) assembly comprising a bottom stage slider (BSS) table and a top stage slider (TSS) table that each have suitably sized apertures or orifices therethrough for allowing the passage of and securely holding an instrumentation column (IC) assembly whose translational movement (i.e., sideways or forward and/or backward directions along a translational plane) and pivotal/rotational movement (i.e., around a perpendicular axis orthogonal to the translational plane and extending through a pivot or fulcrum) are independently controlled by respective slide actuators in order to properly align the IC assembly to a desired trajectory.

Example medical devices for performing treatment under magnetic resonance imaging and related methods are described. An example medical device includes a cannula and a plug. The cannula has a proximal end, a distal end, a first portion, a second portion, and a main body that defines a lumen and a passageway. The first portion extends from the distal end toward the proximal end. The second portion extends from the first portion toward the proximal end. The first portion is formed of first material. The second portion is formed of a second material that is different than the first material. The plug is disposed within the passageway and has a main body that defines a passageway in fluid communication with the lumen defined by the cannula. The plug is formed of a third material that is different than the second material.

A trajectory guiding apparatus and one or more methods associated therewith for facilitating precision-guided alignment and implantation of a DBS therapy device in a patient. A pivotally rotatable stage is pivotally coupled to a base support and a vertical support operative to support a slider assembly arranged to accommodate an instrumentation column (IC) containing the therapy device. A first gimbal drive is disposed between the pivotally rotatable stage and the base support, wherein the first gimbal drive is actuatable to cause a first pivotal motion of the slider assembly including the IC, the first pivotal motion defined along a first arcuate path pivoted around a first pivotal axis. A second gimbal drive is disposed between the pivotally rotatable stage and the vertical support, wherein the second gimbal drive is actuatable to cause a second pivotal motion of the slider assembly including the IC, the second pivotal motion defined along a second arcuate path pivoted around a second pivotal axis perpendicular to the first pivotal axis.

A maneuverable RF coil assembly, useful for being maneuvered at both positions: (i) over at least a portion of a neonate immobilized within a cradle at time of MR imaging; and (ii) below or aside the cradle when it is not required for imaging. The maneuverable RF coil assembly comprises at least one RF coil and maneuvering mechanism. The maneuvering mechanism comprises both: (i) a linear reciprocating mechanism for approaching or otherwise drawing away at least one coil to and from the neonate; and (ii) tilting mechanism for placing at least one coil away from the neonate.

The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.

The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.

A trajectory guiding apparatus and one or more methods associated therewith for facilitating precision-guided alignment and implantation of a DBS therapy device in a patient. A pivotally rotatable stage is pivotally coupled to a base support and a vertical support operative to support a slider assembly arranged to accommodate an instrumentation column (IC) containing the therapy device. A first gimbal drive is disposed between the pivotally rotatable stage and the base support, wherein the first gimbal drive is actuatable to cause a first pivotal motion of the slider assembly including the IC, the first pivotal motion defined along a first arcuate path pivoted around a first pivotal axis. A second gimbal drive is disposed between the pivotally rotatable stage and the vertical support, wherein the second gimbal drive is actuatable to cause a second pivotal motion of the slider assembly including the IC, the second pivotal motion defined along a second arcuate path pivoted around a second pivotal axis perpendicular to the first pivotal axis.

A device for applying external pressure on a surface of an anatomical object, such as a blood vessel, includes at least two jaws, a closing force generating device for applying compressive or closing force to the jaws so to driving the jaws against each other. The device also includes an actuating device for applying counterforce against the compressive force, and a control unit. The control unit controls the operation of the actuating device to apply the counterforce so that the external pressure applied by the jaws into the surface of the anatomical object, such as a blood vessel, is applied in a way to manipulate a flow rate of a fluid circulation in the anatomical object as a function of time in a controllable manner.

The present invention provides an external fixation device and method thereof. The device includes at least an insert for inserting into a patient's tissue such as a bone. The insert is fastened to a fastening assembly which comprises at least a RF heat source member during MRI scanning of the patient. At least a part of the RF heat source member's surface is covered with an absorption material to reduce the direct or indirect transfer of RF induced heat from the member to the insert. The absorption material has an electric conductivity greater than 10.sup.−4 S/m.