A tissue anchor and an anchor delivery and deployment system. The tissue anchor is shiftable between a delivery configuration when housed in anchor garage of the anchor delivery and deployment system, and a deployment configuration when deployed outside the anchor garage. The anchor has a plurality of talons which may be formed from a laser cut tube. The talons may taper, such as widthwise.

A toggle-type suture anchor that incorporates individual suture tensioning and locking without knot tying. The anchor includes several exemplary designs of toggle bodies having a working suture pre-threaded through one or more passages therethrough. A locking suture loop is pre-threaded relative to the working suture and includes a collapsible loop that encircles a portion of the length of suture running longitudinally adjacent the side of the anchor. With the loop open, the working suture can slide through the anchor, however, when the loop is closed the working suture is locked in position to retain tension on the working suture. Alternatively, the locking suture loop can be replaced with a mechanical locking member that moves from a first unlocked to a second locked position. The exemplary anchors can be utilized in a pre-strung connected array of anchors.

A system of toggle type suture anchors is disclosed. The plurality of suture anchors is connected in series by a plurality of independently cinchable working suture loops with one working suture loop connecting each pair of anchors in series to form a chain. Each of the suture anchors as connected by working suture loops allows tensioning of the working suture between itself and the prior anchor implanted in the serial string. Further, each anchor includes a loop type locking mechanism to lock the cinchable working suture loop subsequent to tensioning so that the loop remains fixed in size during cyclic loading during joint use. This creates an independently tensioned suture stitch between each implanted suture anchor and the just previously implanted anchor. In total the system as implanted creates a high density, continuous array of anchor-to-anchor stitches for robust securement of soft tissue to bone.

A distal end of a guide catheter is transvascularly advanced into a left ventricle of a heart of a subject. While the distal end of the guide catheter remains disposed in the left ventricle, a first tissue anchor of an implant is deployed from the distal end of the guide catheter. Subsequently, the guide catheter is retracted while progressively exposing the implant. Subsequently, a second tissue anchor of the implant is anchored to a posterior annulus of a mitral valve of the heart by deploying at least part of the second anchor within a left atrium of the heart, such that the implant extends from the first tissue anchor, over an atrial side of a posterior leaflet of the mitral valve, and to the second tissue anchor. Other embodiments are also described.

Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.

The present invention provides fastener anchoring devices with protruding fasteners releasably attached to graspers for insertion into a target site such as soft tissue. The devices include a retaining mechanism that can be actuated to release the fasteners from the grasper. The devices can include support material preloaded onto the fasteners.

A sutureless implant for replacing damaged natural chordae tedineae of a human or possibly animal heart, the implant including a distal implant part, a proximal implant part, and an artificial chord. The distal implant part is configured to fit in a lumen of an implant delivery device and includes a self-spreading portion spreading radially outside when the distal implant part is released from the lumen, the self-spreading portion being capable of anchoring the distal implant part in human muscle tissue. The proximal implant part is configured to fit in the lumen of the implant delivery device and comprises a self-spreading portion spreading radially outside when the proximal implant part is released from the lumen, the self-spreading portion being capable of bearing on a tissue portion of leaflet tissue. The distal implant part and the proximal implant part are connected by the chord.

A device is described. The device includes a suture guide and a tissue retracting surface to enable accurate and safe delivery of sutures through tissue.

A suture anchor including a base, a deformable portion, and a first passage and a second passage each formed in the base to allow a suture to pass therethrough, wherein the deformable portion is a cantilever state having a fixed end, which is disposed at a side of one end of the base, and a free end, which is disposed at a side of the other end of the base relative to the fixed end and which is separated by a space from the base, and the deformable portion is deformable in a direction in which the free end approaches the base, the first passage communicates the upper side and the lower side of the base, the second passage communicates the space and a side of the one end of the fixed end, and the deformable portion is deformed due to a tensile force applied to the suture.

An anchor for anchoring tensile members to bone includes: a housing having a hollow interior; a collet in the interior of the housing, having a central bore for accepting tensile members therethrough and an exterior surface, wherein the collet is configured to be swaged around the tensile members; a sleeve having opposed interior and exterior surfaces, the sleeve disposed in the hollow interior of the housing and positioned adjacent to the collet, so as to be movable between first and second positions; wherein at least one of the exterior surface of the collet and the interior surface of the sleeve is tapered and the sleeve and the collet are arranged such that movement of the sleeve from the first position to the second position will cause the collet to swage radially inwards around the tensile members; and a flange element, wherein the housing is pivotally mounted to the flange element.