A tissue compression device for forming an anastomosis between first and second anatomical structures may include a first device portion having a first magnetic member and a second device portion having a second magnetic member. The magnetic members are configured to magnetically draw together the first and second device portions to compress tissue positioned therebetween. The compression device further includes a latching mechanism configured to couple the first device portion with the second device portion when the device portions are magnetically drawn together. The latching mechanism may include a first latching member extending from the first device portion and a second latching member extending from the second device portion. The latching members are configured to lockingly engage and thereby couple the first device portion with the second device portion.

There is provided a clamping device and method to resection an inwardly protruding portion present in a hollow organ of a patient, for example during bariatric surgeries, an appendectomy, a resection or excision surgery, etc. The clamping device includes a magnet assembly implantable into a lumen of the hollow organ of the patient. The magnet assembly has magnet elements arranged in two zones and is configured to be positioned around a base of the inwardly protruding portion. Opposing magnet elements are magnetically coupled together to compress opposite walls of the base therebetween until the walls are fused together, thereby partitioning the inwardly protruding portion from the remainder of the organ. The inwardly protruding portion can be pulled into the lumen of the hollow organ prior to the clamping device being positioned around the base. The inwardly protruding portion can be removed from the hollow organ to resection the organ.

The invention is an implantable magnetic anastomosis device having an exoskeleton that directs self-assembly. The design allows the device to be delivered in a linear configuration using a minimally-invasive technique, such as endoscopy or laparoscopy, whereupon the device self-assembles into, e.g., a polygon. A coupled set of polygons define a circumscribed tissue that can be perforated, or the tissue can be allowed to naturally necrose and perforate. The device can be used to create anastomoses in a variety of tissues, such as tissues found in the gastrointestinal, renal/urinary, and reproductive tracts. New procedures for using anastomoses, e.g., surgical bypass are also disclosed.

Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing.

A system for endoscopically forming an anastomosis between two naturally adjacent points in the digestive tract. The system utilizes elongate magnetic devices that, when connected across a tissue boundary, necrose tissue until an anastomosis forms and the devices are passed naturally. Despite the elongate shape of the devices, the resulting anastomosis is substantially round. As such, round anastomoses can be formed having increased diameters merely by increasing the lengths of the devices, obviating the need for wider endoscopes.

An organ anastomosis system 1 includes a pair of disc-shaped magnets 2 and 3 which pinch and compress adjacent organ walls 6a and 6b of an object by magnetically attracting each other with the organ walls 6a and 6b interposed therebetween so as to cause local apoptosis and form a continuous hole and an anastomotic part conglutinating around the peripheral part of the continuous hole are formed, which continuous hole specially connects the organ walls with each other. The side circumferential surfaces of respective disc-shaped magnetic bodies 2a and 3a of the pair of the magnets 2 and 3 are formed as tapered surfaces 2b and 3b which gradually decrease in diameter from one end to the other end in the axial direction of the magnetic bodies 2a and 3a.

A method and devices that endoscopically create an anastomosis between two sections of the digestive tract, thereby allowing at least some chyme to bypass a section of the digestive tract while, optionally, the remaining chyme passes through the entire tract.

Systems and methods for positioning a magnetic implant for forming an anastomosis at a target location in a digestive tract of a patient are provided. The system can include first and second magnetic implants configured to magnetically couple to each other through two adjacent walls of the digestive tract at a desired site of the anastomosis to compress a portion of the two adjacent walls therebetween and form a necrotic area that becomes surrounded by a scarred edge following a healing time period. The system further can further include a positioning marker positionable at a target location corresponding to a first location on one side the desired site of the anastomosis for the first magnetic implant, the positioning marker being configured to intercept the first magnetic implant at the target location once swallowed by the patient.

The present disclosure provides description of applicators to implement modular magnetic anastomosis device. In one embodiment the delivery device is a laparoscopic instrument for MISS surgery, in another embodiment the delivery device is endoscopy or colonoscopy instrument for NOTES surgery.

A device for anastomosis of a tubular structure comprises first and second hollow members having a rigid part and an elastic part, and a connection member for interlocking the first and second members. The elastic parts are essentially circular rings, and are made of a polymeric, a biocompatible and/or biodegradable material. The rigid parts have an outer surface that is partly semi-circular in cross section, wherein the diameter at a non-connecting end is larger than or equal to the diameter at a connecting end, which ends in an edge. The first and second members are connected to each other so that a distance is formed between the elastic parts. A cavity is formed between the rigid parts and the connection member and the tubular structure, when arranged in the device.