Devices and methods for implantation at a native mitral valve having a non-circular annulus and leaflets. One embodiment of the device includes a valve support having a first region configured to be attached to a prosthetic valve with a plurality of prosthetic leaflets and a second region. The device can further include an anchoring member having a longitudinal dimension and including a first portion configured to contact tissue at the non-circular annulus, a second portion configured to be attached to the valve support, and a lateral portion between the first portion and the second portion. The second portion of the anchoring member is attached to the second region of the valve support while in a low-profile configuration in which the anchoring member and the valve support are configured to pass through vasculature of a human. The lateral portion is transverse to the longitudinal dimension. The anchoring member and the valve support are configured to move from the low-profile configuration to an expanded configuration in which the first portion of the anchoring member at least partially adapts to the non-circular annulus of the native mitral valve and the first region of the valve support is spaced inwardly from the first portion of the anchoring member relative to the longitudinal dimension of the anchoring member such that a shape of the first region of the valve support is at least partially independent of a shape of the first portion of the anchoring member.

An implantable vascular device comprises an expandable and compressible implant body, a housing, a rotatable member, and a locking member. The housing is coupled to a first end portion of the implant body. The rotatable member is coupled to the housing and to a second end portion of the implant body such that rotating the rotatable member relative to the housing and the implant body expands or contracts the implant body. The locking member is coupled to the rotatable member and configured to move between an unlocked state and a locked state. In the unlocked state, the locking member allows the rotatable member to be rotated relative to the housing and the implant body. In the locked state, the locking member prevents the rotatable member from being rotated relative to the housing and the implant body.

The present invention relates to an anastomosis system for realizing anastomosis between first and second hollow structures, such as end-to-side anastomosis, by way of a joining member and an applicator. The anastomosis system comprises an annular joining member adapted for joining the first and second hollow structures, a tubular member adapted to position the joining member at or proximate to a distal end of the second hollow structure and to be at least partially inserted into the second hollow structure, a support member adapted to hold the second hollow structure and a mechanism, for actuating the joining member when positioned at or proximate to the distal end of the second hollow structure, which joining member is actuated substantially radially relative to a longitudinal axis of the tubular member.

The present invention relates to a support for an abrasive comprising a nonwoven fabric being a through-air thermally bonded nonwoven fabric comprising multicomponent binder fibers. The present invention relates also to a method of forming said support and to the use of said support in the manufacture of an abrasive article.

This disclosure is directed toward sealable and repositionable implant devices that are provided with one or more improvements that increase the ability of implants such as endovascular grafts to be precisely deployed or re-deployed, with better in situ accommodation to the local anatomy of the targeted recipient anatomic site, and/or with the ability for post-deployment adjustment to accommodate anatomic changes that might compromise the efficacy of the implant.

A surgical tool system. Various embodiments of the surgical tool system may comprise surgical instrument that has a handle assembly that operably supports a drive system therein for generating drive motions upon actuation of a movable handle portion operably coupled to the handle assembly. An elongated body protrudes from the handle assembly and operably supports a control rod therein that interfaces with the drive system. The surgical tool system further includes at least two surgical tools selected from the group of surgical tools consisting of: manipulators, nippers, scissors, endocutters, tissue thickness measurement devices, staple appliers, clip appliers, syringes for applying glue, sealant, drugs or medicaments and cauterization devices wherein each of the surgical tool within the group of surgical tools at least has a housing that is removably couplable to the elongated body and a drive assembly that is removably couplable to the control rod for receiving the drive motions therefrom.

A surgical stapler comprising a handle assembly, an elongated body portion extending distally from the handle assembly, and a head portion disposed adjacent a distal portion of the elongated body portion and including an anvil assembly and a shell assembly. The anvil assembly is movable in relation to the shell assembly between spaced and approximated positions. The anvil assembly has an anvil head and a plurality of projections extending proximally of the anvil head, the projections engageable with a portion of the shell assembly.

The present invention relates to a joining member for an anastomosis system for realizing anastomosis between first and second hollow structures, such as end-to-side anastomosis. The joining member is annular and is adapted for joining the first and second hollow structures. The joining member includes a plurality of interconnected loops forming the annular body and a plurality of joining elements for joining the hollow structures connected to the annular body at locations where adjacent loops are interconnected to each other, and wherein the loops are configured to permit radial expansion of said annular body to expand said joining member from a first position to a second position having a second, larger diameter than the first position.

A surgical stapler comprising a handle assembly, an elongated body portion extending distally from the handle assembly, and a head portion disposed adjacent a distal portion of the elongated body portion and including an anvil assembly and a shell assembly. The anvil assembly is movable in relation to the shell assembly between spaced and approximated positions. The anvil assembly has an anvil head and a plurality of projections extending proximally of the anvil head, the projections engageable with a portion of the shell assembly.

A shell assembly includes a housing, a cartridge, and a hollow bushing. The housing defines a longitudinal axis and a cavity. The cartridge is supported on the housing and includes a plurality of staples. The hollow bushing is positioned within the cavity of the housing. The hollow bushing includes a distal portion and a proximal portion formed of a rigid material, and an expandable portion that connects the distal and proximal portions. The hollow bushing has an initial configuration where the hollow bushing defines a first length along the longitudinal axis and a stretched configuration where the hollow bushing defines a second length along the longitudinal axis which is greater than the first length.