An apparatus includes a plurality of beads and a linking assembly joining the beads together. The beads include a housing defining a first opening, a second opening, and a chamber extending between the first opening and the second opening. A magnet is contained within the housing. The beads and the linking assembly are arranged in an annular arrangement and sized to form a loop around an anatomical structure in a patient. The loop may move between a contracted and expanded configuration. The loop is magnetically biased toward the contracted configuration by a magnetic bias of the beads. The linking assembly includes a first link element having an elongate body extending in the chamber of the first bead and a sealing element attached to the elongate body housed within the first opening of the first bead to thereby form a hermetic seal.

An apparatus includes a first shaft extending distally from a proximal end to a distal end. The first shaft is sized to fit within an esophagus of a patient. The first shaft includes a first shaft lumen extending distally to the distal end. The apparatus further includes a second shaft slidably positioned within the first shaft lumen. The second shaft is sized to fit within the shaft lumen and extend through the transverse bore. The second shaft is configured to receive a guide element and a sphincter augmentation device so that the sphincter augmentation device may be deployed through an interior of the esophagus to an exterior of the esophagus.

A device may include an elongated housing formed of an optically transparent material, the housing extending from a proximal end to a distal end and including a lateral wall extending from the proximal end to a distal tip of the housing, the housing defining a lumen extending into the housing from a proximal opening in the proximal end of the housing. The device also may include a first port extending through the lateral wall of the housing to open the lumen of the housing to an exterior of the housing, the first port being sized and shaped to receive therein a target portion of tissue to be inspected and/or treated.

A tissue clip application fitting or retrofitting set comprising a cap attachment configured to be mounted on the distal end portion of a shaft-type medical endoscope. The cap attachment has a proximal mounting or placement portion and a distal tissue clip holding portion, in the region of which a cavity open at least in the distal direction is formed inside a radially outward-pointing peripheral surface. A tissue clip is supported on the peripheral surface, and can be displaced in the distal direction by a pull-off device in the form of a pull-off ring mounted on the radial outer peripheral surface of the tissue clip holding portion so that it can axially slide and move the tissue clip. The pull-off ring is operated by a cable pull that is in direct contact with the pull-off ring for the transmission of sliding force in at least two coupling or engagement points.

Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include an elongate body having a cavity at a distal end and a tissue retractor extendable distally from the distal end of the elongate body. The tissue retractor may include an expansion mechanism. The expansion mechanism may include a plurality of arms each having a first end coupled around a distal cap and expandable radially outward from the distal cap such that an anchoring mechanism on a second end of the arms is engageable with selected tissue for resection of the body lumen. The tissue resection device may further include a tissue resecting device.

An apparatus applicable for the ligation of internal tissue in a created or natural cavity in animals or in the human body, for example varicose veins in the gullet or a duodenal diverticulum, by means of an elastic band (19) while observing the ligations through an endoscope. The apparatus includes an automatic trigger unit (1) mounted firmly on the handle of the endoscope which can release a number of elastic bands (19) with the aid of a single-stranded trigger cord (11). Only a single elastic band (19) is released for each ligation thereby establishing a one-man-operated apparatus.

Provided herein is a mechanical device including a rotating spool assembly and a disposable valve assembly. The rotating spool assembly includes a hub, an arm, and a spool inserted through an opening in the arm. The rotating spool assembly can be sterilized after each use. The disposable valve assembly includes a mating stem member, a sealing member, and a flushing port member. The disposable valve assembly can be disposed of after every use. A loading member is also provided including a wire that can be formed from metal drawn out into a thin flexible thread. The loading member can be pre-formed in a helix to form coils in the wire. A release cord is provided including a braided cord with two single filaments and a plurality of beads formed along a length of the single filaments at a distal end of the braided cord.

A multiple band endoscopic ligation device comprises a single pull string and a plurality of beads positioned on said pull string and between each successive band. The device is configured to be coupled to the distal end of an endoscope and is used to deploy multiple elastic bands around target tissues to be ligated. The device includes a tapered cylindrical body about which a plurality of elastic bands are stretched and positioned. The pull string includes multiple sets of two beads fixed to the string wherein one bead is placed directly behind and in contact with the other. The string is wrapped around the device's body and under each band such that at least one pair of beads is positioned between the elastic bands and one pair of beads is positioned proximally to the most proximal band. As the string is pulled, the beads push the bands sequentially off the distal end of the device and around a tissue to be ligated. The use of two adjacent beads on the string to push off each band ensures that the bands will not slip over the beads, thereby preventing a misfire.

A novel catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.

A ligating system having a ligating apparatus configured to attach to a distal end of a scope and to hold a ligating band thereon; an activating cord configured to extend down a working channel of the scope and attach to the ligating apparatus; and a line pulling assembly including: a central body; an attachment mechanism on the central body configured to attach the line pulling assembly to a proximal end of the scope; an access channel through the central body and in communication with the working channel of the scope, the access channel providing an open inlet to the working channel of the scope when the line pulling assembly is attached to the proximal end of the scope; and a winding mechanism attached to the central body, wherein the winding mechanism is configured to pull the activating cord proximally such that the ligating band is removed from the ligating apparatus.