A method of constructing a detachment system for delivering an implantable medical device to a target location of a body vessel is presented. The method includes forming a compressible portion on a distal tube, engaging an implantable medical device with an engagement system, extending the engagement system through the distal tube such that the implantable medical device is distal of a distal end of the distal tube, applying a force to the engagement system to compress the compressible portion to a compressed state, fixing the engagement system to the distal tube to maintain the compressed state of the compressible portion, and joining a proximal end of the distal tube to a distal end of a proximal tube. The engagement system can include a loop wire that is fixed to the distal tube and engages the medical device.

Devices used to restrict flow within a blood vessel are disclosed. Devices within the scope of this disclosure include a braided lattice of nitinol wires that form self-expanding enclosures of an embolic structure. The devices may further include embolic particles disposed within the enclosures. Methods of deploying the devices with the embolic particles are disclosed. Methods of manufacturing the devices with the embolic particles disposed within the enclosures are disclosed.

Devices and methods are provided for trans-esophageal aortic flow control. The device comprises a controller, an esophageal tube extending from the controller, an anchor device at a distal end of the esophageal tube and configured to anchor the distal end of the device inside a patient's stomach, and an actuator positioned proximally to the anchoring device by a sufficient distance so that the actuator will be proximal to the intersection of the patient's esophagus with their diaphragm when the anchoring device is positioned inside of the patient's stomach. In this position, the anchoring device is aligned with the location at which the patient's esophagus and aorta cross that is above (or proximal to) the intersection with the patient's diaphragm, with the patient's aorta then positioned between the spine and the esophagus. Thus, when the actuator is engaged, a compressive force is applied by the actuator against the interior of the patient's esophagus and, in turn, upon their underlying aorta so as to significantly occlude blood flow through their aorta and reduce the risk of lethal hemorrhaging from an abdominal wound.

Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a medical device includes a frame member and a tissue growth member. The frame member includes a unitary, seamless central portion having a plurality of struts defining a multi-cellular structure and an anchoring system, the plurality of struts extending between and configured to self-expand and directly bias the anchor system to anchor the frame member at least partially within the LAA. With this arrangement, the tissue growth member is attached to the frame member to occlude the LAA.

An intravascular system having a first catheter having a first non-circular transverse cross-sectional configuration and a first delivery device configured for insertion into the lumen of the catheter. The first delivery device includes an implantable medical device and an elongated member supporting the first medical device such that the first elongated member and the first medical device are movable through the lumen of the first catheter. The first elongated member has a second non-circular transverse cross-sectional configuration corresponding to the first non-circular transverse cross-sectional configuration to thereby inhibit rotation of the first elongated member within the catheter and control orientation of the first medical device relative to the catheter.

An implantable expandable device includes an occluding surface oriented substantially in a transverse plane. The occluding surface is bounded by a lateral occluding surface edge and a medial occluding surface edge. The occluding surface has an occluding surface body located transversely between the lateral and medial occluding surface edges. A supporting structure is located entirely inferiorly to the occluding surface. The supporting surface includes a plurality of struts extending substantially in the superior-inferior direction. At least a first one of the struts is a full-height strut and spans substantially a full superior-inferior height of the device. At least a second one of the struts is a reduced-height strut and spans substantially less than a full superior-inferior height of the device. The occluding surface substantially occludes a transverse cross-section of the false lumen to substantially block bloodflow in the superior-inferior direction within the false lumen.

The invention relates to an aneurysm coil that is made up of a single wire of a noncircular cross-sectional shape. The wire is coiled in a helical configuration to have an outer surface and an inner surface. The outer surface of the wire does not have a round outer surface. The aneurysm coil of the present invention is designed to encourage cellular adhesion and tissue growth along the coil surface by employing a wire having a substantially non-circular cross sectional area, such as a T shape, a triangle, square, rectangle, oval, pentagon, hexagon, septagon, octagon, star, rhombus, as well as a variety of non-geometric shapes. The use of a wire having such a cross sectional shape promotes endothelial cells to adhere and grow within the gaps created by the juxtaposition of the wire forming a coil, thus anchoring the coil to its intended location, promoting thrombosis, endothelial growth across the opening of the aneurysm, and eventual healing of the aneurysm.

A medical device including stabilizing wires that are selectively movable from a first and second position and a delivery system including the same are described herein. The medical device includes a device body and the stabilizing wires coupled thereto. Each stabilizing wire has a proximal and distal end. In the first position, at least a portion of the distal end extends radially outwardly from the device body, and in the second position, the distal end is retracted within the device body. Each stabilizing wire includes a linear portion at the proximal end, a hook portion at the distal end, and a ramp segment extending between the linear portion and the hook portion, including a ramp incline portion that extends at a first angle from the linear portion to a ramp apex, and a ramp decline portion that extends at a second angle from the hook portion to the ramp apex.

A wall (39) of a catheter (38) (a) includes a braided portion (41) having an outer surface (45), an inner surface (47), and a braided interior (53) between the outer and inner surfaces (45, 47), and (b) is shaped to define first and second longitudinally-running channels (27a, 27b) therethrough. A distal portion of the catheter (38) is shaped to define first and second lateral openings (26a, 26b). An angle between (a) a first line (76) running between the first and second lateral openings (26a, 26b), and (b) a second line (78) that is parallel to a central longitudinal axis of the catheter (38) when the catheter (38) is straight, is between 30 and 150 degrees. A flexible longitudinal member (14) passes from a proximal portion of the catheter (38) to the distal portion via the first channel (27a), out of the first channel (27a) via the first lateral opening (26a), into the second channel (27b) via the second lateral opening (26b), and from the distal portion to the proximal portion via the second channel (27b).

An endovascular treatment system includes a delivery sleeve that is insertable into an intravascular catheter. A therapeutic device is housed coaxially within the delivery sleeve and both are advanced within the catheter in combination. An advancement mechanism is connected to the therapeutic device to advance the therapeutic device out of the delivery sleeve and into a patient. The delivery sleeve includes a stop positioned on the proximal end. The stop contacts the proximal end of the catheter, limiting the distance the delivery sleeve is inserted into a catheter.