This disclosure relates generally to medical devices, systems, and methods for locating devices and/or anatomy during medical procedures. More particularly, in some embodiments, the disclosure relates to medical device and/or anatomy locating devices, access devices, and systems and methods thereof, for use during, e.g., gastrojejunostomy procedures. In an aspect, a medical device locator may include an elongate member (such as sheath or guidewire) having a proximal end, a distal end, a longitudinal axis, and a length extending along the longitudinal axis. A location device may be disposed along the length of the elongate member.

A medical system includes a porous body positioned at a target site within a subject, a tube including a wall defining a tube lumen, where the tube is connected to the porous body at a first end of the tube, and a sealing device to seal the target site from a body lumen. When the sealing device seals the target site from the body lumen, the tube extends from the target site into the body lumen.

A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.

Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

According to exemplary embodiments of the present disclosure, devices, systems, and methods for pyloric occlusion in an endoscopic procedure may include a first flange and a second flange connected to the first flange by a saddle region having a lumen. The second flange may be proximal to the first flange. The pyloric occlusion device may further include a closure element. The closure element may be configured to occlude a flow of material through the lumen, including across the pylorus when deployed. The closure element may be a closure of the lumen by rotation of one of the first or second flanges about the saddle region relative to the other of the first or second flange.

An occlusion device includes a body having a plurality of layers and defining a first diameter. Each layer of the plurality of layers is releasably coupled to a respective inwardly-adjacent layer. An outermost layer of the plurality of layers is removable from the respective inwardly-adjacent layer. Removal of the outermost layer reduces an outer diameter of the body from the first diameter to a second diameter that is less than the first diameter.

Method for introducing and maintaining a level of negative pressure in a body cavity of at least 80 mmHg using a tube having an elongate distal portion and a proximal portion having first and second arms, each arm having a lumen in flow communication with one another and with the body cavity via apertures at or near the distal end of the tube, wherein the first arm or tubular extension therefrom is adaptable to receive suction from a suction source. An indicator, arranged in relation to the second arm, signals when a specific negative pressure has been exceeded in the tube, or a valve, arranged in relation to the second arm, admits ambient air into the lumen of the second arm when suction is applied to the tube and differential air pressure between the air in the lumens of the tube and ambient air exceeds a specified amount.

A method of operating a surgical anchoring system can include inserting an outer sleeve of a surgical instrument at least partially into a first natural body lumen, the outer sleeve having a working channel. The method can include inserting a channel arm of the surgical instrument through the working channel of the outer sleeve and into a second natural body lumen. The channel arm has at least one first anchor member coupled thereto and a control actuator operatively coupled to the at least one first anchor member. The method can include expanding the at least one first anchor member from an unexpanded state to an expanded state to form an anchor point at a portion of the second natural body lumen. The method can include controlling, by the control actuator, a motion of the channel arm to selectively manipulate an organ associated with the first and second natural body lumens.

A medical device includes a vessel member, a port that couples a compartment interior of the vessel member to a region exterior of the vessel member, and a tubular member that defines a lumen. A distal end of the tubular member is attached to an internal surface of the vessel member within the compartment so that a portion of the internal surface of the vessel member provides a seal at a distal end of the lumen. The tubular member passes through the port, and the proximal end of the tubular member is configured to remain exterior of the compartment. A delivery of a sufficient amount of a filling material into the lumen of the tubular member causes a length of the tubular member to pass through the port and into the vessel compartment.

The devices and methods can prevent pulmonary aspiration thereby allowing for procedures, such as an endoscopic procedure, to be performed under sedation without general anesthesia. The device may include a first end, a second end, and a length therebetween. The body may have a central lumen along the length. The device may include a first base member fixedly disposed at the first end and a second base member fixedly disposed at the second end. The device may also include an expandable assembly movable along the length of the body with respect to the first base member. The expandable assembly may be configured to move between a collapsed configuration and an expanded configuration. The expandable assembly may also be configured to expand radially with respect to the body when in the expanded configuration.