According to the present disclosure, there is provided a device which can have a funnel catheter having an expandable distal tip. The funnel catheter can originally be placed in a collapsed configuration for delivery through vasculature to a target thrombus location. Once positioned, the expandable tip can be radially expanded to create a funnel for aspirating or retrieving clots from a vessel. The funnel catheter can be at least partially enclosed by an outer sheath for purposes of delivery to the target site or to assist in expansion of the funnel catheter tip.

Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

The invention relates to radiopaque shape memory foam compositions and methods of using the compositions. In certain embodiments, the compositions are used in neurovascular occlusion applications.

An apparatus is configured to be implanted within a biological lumen. The apparatus includes a plurality of magnetic elements and a coupling body. The magnetic elements are arranged in an annular array extending form an axis. The annular array defines an occludable opening configured to transition between an occluded state and an opened state. The magnetic elements include a first magnetic element and a second magnetic element. The second magnetic element is located adjacent to the first magnetic element. The second magnetic element includes a polymer magnetic material formed in a shape designed to geometrically interlock with the first magnetic element in the occluded state. The second magnetic element is configured to elastically deform to transition the occludable opening from the occluded state to the opened state. The coupling body is configured to affix to a portion of the first magnetic element and a portion of the second magnetic element.

A blood flow reducer (20) for insertion in a blood vessel, the reducer (20) being adapted to be deformed from a first configuration to an expanded configuration, wherein, in the expanded configuration, the reducer (20) defines an axial lumen (40) for allowing blood flow therethrough, the axial lumen (40) having a smallest cross-section, the reducer (20) has a largest cross-section, and the smallest cross-section is comprised between 20% and 90% of the largest cross-section. In particular, the smallest cross-section is strictly comprised between 70% and 90% of the largest cross-section. A method for preconditioning a liver of a living being before partial hepatectomy, wherein a 10 to 30% stenosis is created in a branch of a portal vein conducting blood to a first liver lobe.

An apparatus is configured to be implanted within a biological structure. The apparatus includes an annular retaining assembly and an occlusion member. The annular retaining assembly defines an annular opening and includes an outer ring and an inner ring. The outer and inner rings are disposed about a central axis. The outer ring also has an outer wall, an inner wall, and a bio-absorbable material. The inner ring defines an annular opening and is attached to the inner wall of the outer ring. The inner ring also includes a surface to promote tissue in-growth. The occlusion member extends from the annular retaining assembly toward the central axis. The occlusion member also includes a plurality of magnetics. The occlusion member is magnetically biased to a first position that substantially occludes the annular opening. The occlusion member is configured to elastically deform to a second position that substantially unblocks the annular opening.

Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

A blood vessel occlusion device comprising a plurality of legs having a deployed state wherein each of the plurality of legs is angled outwardly toward a vessel wall and a delivery state wherein the plurality of legs are sized and shaped for pushing into a target blood vessel and substantially in parallel to a common longitudinal axis. Each leg has an anchoring tooth at a distal end thereof and a gripping point formed therealong. Each leg switches from deployed state to delivery state by a retention element and maintained in delivery state when said retention element is supported by the gripping point.

Disclosed herein are methods and devices for treating pancreatitis. In the methods described herein, the distal portion of a catheter is routed into the pancreatic duct. The catheter delivers to the pancreatic duct an effective amount of a composition at an effective infusion pressure, wherein the amount and infusion pressure of the composition are effective to decrease the secretion of digestive enzymes from one or more exocrine tissues of the pancreas. The reduction of digestive enzymes may reduce damage to the islet cells typically seen in chronic pancreatitis. Backflow of the composition out of the pancreatic duct is limited, for example, by an occluding system, and aspiration system, or both.

A medical device and system for modifying a left atrial appendage (LAA), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure. Each frame segment includes a hub portion and at least one leg portion, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member, and the at least one leg portion extending from the hub portion. With this arrangement, a tissue growth member is coupled to the frame segments.