Provided herein are methods and compositions for treating bone osteonecrosis comprising: at least one of a Gelatin tyramine (GT), a gelatin-heparin tyramine (GHT), a gelatin methacryloyl (GelMa), a gelatin acryloyl (GelAC), collagen, or a hydrogel-forming peptide that can be formed ex vivo or in situ for the treatment of bone osteonecrosis; at least one bone growth promoting agent or a macrophage depletion reagent; and optionally one or more pharmaceutically acceptable carriers.

Disclosed is a system to engage one or more tools. In the system a drive shaft and collet may be assembled to engage and disengage, selectively, a plurality of tools. Further, a tracking device may be used to track a location of at least a portion of the tool.

A cutting accessory for use with a powered surgical handpiece includes an elongated shaft, a tissue working member, and a proximal section. The elongated shaft has proximal and distal ends, and a longitudinal axis. The working member is attached to the distal end of the shaft. The proximal section extends proximally from the distal end and includes a plurality of faces extending inwardly from an outer surface of the shaft. Each face has at least one shallow portion and is shaped to receive a clamping member. At least two of the faces are arranged linearly, extending along the shaft proximal section. A flat extends distally forward of the distalmost face, and is located a distance from the shaft longitudinal axis greater than the distance the shallow portions are located from the longitudinal axis and less than the distance the outer surface of the shaft is from the longitudinal axis.

A drill sleeve, including: an outer sleeve with an internal collet at a distal end of the outer sleeve, a slot, and an inner opening; a handle connected to the outer sleeve; an inner sleeve with an inner opening configured to receive and guide a drill bit, wherein the inner sleeve is configured to slide inside the inner opening of the outer sleeve; a trigger; a connection member connected to trigger and the inner tube, wherein the connection member passes through the slot in the outer sleeve and a biasing member configured to apply a biasing force between the handle and the trigger wherein the biasing force drives the inner sleeve into the outer sleeve, wherein when a distal end of the inner sleeve engages the internal collet, the internal collet is configured to engage a screw hole in a bone plate, align the drill sleeve with a nominal axis of the screw hole, and secure the drill sleeve to the screw hole.

An oscillating drive mechanism for a surgical tool includes a motor having a rotor, a crank assembly hub, a link secured to the crank assembly hub, a pivot shaft, a shuttle including an arcuate rack gear secured to the link so that rotation of the crank assembly hub provides reciprocating rotary motion to the arcuate rack gear about the pivot shaft. A gear is meshed with the arcuate rack gear and is secured to an output shaft, whereby rotational motion of the motor induces rotary oscillating motion to the output shaft.

Orthopedic implants, systems, instruments, and methods. A bi-portal lumbar interbody fusion system may include an expandable interbody implant and minimally invasive pedicle-based intradiscal fixation implants. The interbody and intradiscal implants may be installed with intelligent instrumentation capable of repeatably providing precision placement of the implants. The bi-portal system may be robotically-enabled to guide the instruments and implants along desired access trajectories to the surgical area.

Aspects of the present disclosure relate to systems for performing a surgical procedure using a power tool or power instrument with systems, devices and/or control units for adjusting, regulating, interrupting, and/or restoring electric current to the power tool or instrument during operation, for example, when the power tool or instrument is at a predetermined distance to a boundary of a safe zone or a target volume of operation.

A drill sleeve, including: an outer sleeve with an internal collet at a distal end of the outer sleeve and an inner opening; a handle connected to the outer sleeve; an inner sleeve with an inner opening configured to receive and guide a drill bit, wherein the inner sleeve is configured to slide inside the inner opening of the outer sleeve; a trigger connected to the inner sleeve; and a biasing member configured to apply a biasing force between the handle and the trigger wherein the biasing force drives the inner sleeve into the outer sleeve, wherein when a distal end of the inner sleeve engages the internal collet, the internal collet is configured to engage a screw hole in a bone plate, align the drill sleeve with a nominal axis of the screw hole, and secure the drill sleeve to the screw hole.

A bone, cartilage, and disk removal tool assembly is provided with a motor mounted in a housing. A spindle is mounted for rotation to the housing. A rack-and-pinion mechanism is operably driven by the motor and connected to the spindle to oscillate the spindle for providing a rotary oscillating cutting operation. According to at least another embodiment, a plurality of cams is supported in the housing and driven for rotation by the motor. A plurality of followers is mounted for rotation to the housing, in engagement with the plurality of cams so that one rotation of the plurality of cams oscillates the plurality of followers more than once while preventing over-rotation of the plurality of followers. A peak angular acceleration of the spindle is less than nine million radians per second squared.

A surgical handpiece system (10) includes a high-speed surgical bur assembly (102) and a surgical handpiece assembly (104). The high-speed surgical bur assembly has a nose tube (17, 106) and a driveshaft (24, 110) at least partially disposed within the nose tube. A cutting tool (18, 114) is coupled to a distal region of the driveshaft. The cutting tool and the driveshaft are configured to rotate relative to the nose tube. The surgical handpiece system comprises a hub (14, 146) and a rotatable drive chuck (30, 34, 172) for alignment and coupling to the nose tube and the driveshaft. A motor (12) is configured to rotate the rotatable drive chuck, the driveshaft, and the cutting tool when the driveshaft is coupled to the rotatable drive chuck.