An orthopaedic fixation assembly for prosthetic biologic attachment. The orthopaedic fixation assembly may include a main body with a longitudinally-extending stem having a proximal end, a distal end, and a cavity body. An anchor plug may be configured to be received within the stem cavity, and securable thereto via complementary mating surfaces. A spindle structure may be fixedly attached to the proximal end of the longitudinally-extending stem and protrude outwardly therefrom such that a portion of the structure extends externally beyond the resected cavity of the bone that may prevent rotational motion of the spindle. The spindle structure may have at least one compliant biasing member configured to apply a compressive force to the surrounding bone. A porous coating may be at the juncture between stem and spindle structure, on the spindle, and the splines and anti-rotation chocks, improving the initial stability of the implant and facilitating long-term bone ingrowth.

An IM tibial nail aiming guide for providing proximal and distal screw fixation in an intramedullary nailing (IMN) of a tibia includes an attachment that connects and disconnects easily from a jig's proximal handle. Specifically, the IM tibial nail aiming guide functions as an aiming guide for accurate fixation of all the respective proximal and distal screw holes in a tibial nail. The IM tibial nail aiming guide has a length and angle that are adjustable, affording the ability to use this IM tibial nail aiming guide with any tibial nail. This IM tibial nail aiming guide is made of radiolucent material that allows for a confirmatory fluoroscopic imaging to verify that both the proximal and distal screws are fixated appropriately. The IM tibial nail aiming guide permits a more accurate, safe, versatile, and efficient approach to tibial IMN.

A retrograde intramedullary nail for insertion in the medullary canal of a femur includes a body that is elongate and defines a leading end and a trailing end spaced from each other at a length sufficient to extend from an intercondylar region at least to a subtrochanteric region of the femur. The body further defines a leading portion that extends to the leading end. The leading portion defines at least one locking hole configured to receive a fixation member. The at least one locking hole defines a central hole axis that is oriented to extend through the neck and head of the femur.

Intramedullary nails, systems, and methods. The intramedullary nail may include a generally elongate body extending from a first, distal end to a second, proximal end. The distal end may include one or more openings configured to receive one or more bone anchors that extend transversely through the distal end intramedullary nail, and thereby configured to secure the distal end of the nail. The proximal end may also include one or more openings configured to receive one or more bone anchors that extend transversely through the proximal end of the intramedullary nail, and thereby configured to secure the proximal end of the nail. In some embodiments, the proximal opening may contain one or more relief cuts.

Embodiments herein employ a flexible orthopedic alignment guide for surgical implantation of flexible bone plates. Specifically, the alignment guide is designed to be used in conjunction with flexible bone plates whereby flexible sections of the alignment guide aid in alignment of drill bits and fasteners with the fastener holes of the bone plate. The flexible guide is designed to flex in a similar manner to the bone plate, thus maintaining positive engagement without compromising hole alignment.

Provided herein are methods and compositions for treating bone osteonecrosis comprising: at least one of a Gelatin tyramine (GT), a gelatin-heparin tyramine (GHT), a gelatin methacryloyl (GelMa), a gelatin acryloyl (GelAC), collagen, or a hydrogel-forming peptide that can be formed ex vivo or in situ for the treatment of bone osteonecrosis; at least one bone growth promoting agent or a macrophage depletion reagent; and optionally one or more pharmaceutically acceptable carriers.

A system is provided that includes a first implant including first and second screw receiving holes having respective first and second longitudinal axes. A second implant includes third and fourth screw receiving holes having respective third and fourth longitudinal axes. At least one drill guide has respective fifth and sixth longitudinal axes. A targeting guide is provided for aligning the drill guides with each of the first and second implants simultaneously, so that the first, third and fifth longitudinal axes lie along a same line as each other, and the second, fourth and sixth longitudinal axes lie along a same line as each other.

A combined inserter for insertion of an intramedullary nail and a bone plate together. The combined inserter includes a body that includes a longitudinal axis, a distal end, and a proximal end. The combined inserter includes an intramedullary nail coupler coupled to the body and configured to couple to an intramedullary nail; and a bone plate coupler coupled to the body and configured to couple to a bone plate.

An intramedullary nail includes a shaft between a proximal end and a distal end. The distal end includes a first bend that extends from an anterior side of the intramedullary nail toward a posterior side and a second bend that extends from the posterior side toward the anterior side of the intramedullary nail. The two bends transfer an insertion force on a distal end of the intramedullary nail to, and along a longitudinal axis of the shaft of the intramedullary nail.

A bone plate includes body having a bone-facing surface that faces a first side of the long bone when the bone plate is in use. The long bone includes the first side, a second side, a third side, and a fourth side. The bone plate also includes a low-profile fixation assembly that can secure one end to the long bone. The low-profile fixation assembly fixates the one end to the long bone by approaching the one end from one of the second side, the third side, and the fourth side of the long bone.