A catheter system and corresponding methods are provided for accessing a blood vessel true lumen from a sub-intimal plane of the vessel. The catheter includes components that are symmetric about the longitudinal axis and allow for reentry without the need to ensure a correct orientation of the cannula.

A method and system for secure ultrasound treatment of living tissues using an ultrasound probe comprising a reflective cavity in acoustic communication with living tissues, a transducer to emit an ultrasound wave in the reflective cavity and a transducer to acquire a backscattered signal in the reflective cavity. The method comprises the steps of a) emitting a first ultrasound wave in the reflective cavity that generates a backscattered ultrasound wave in the reflective cavity, b) acquiring a backscattered signal in the reflective cavity, c) determining whether an insonification can be safely performed by computing a similarity value between the backscattered signal and a predefined reference signal, and d) if an insonification can be safely performed, treating the living tissues with a second ultrasound wave emitted in the reflective cavity. The second ultrasound wave is focused a target point of the living tissues and generates a pressure pulse resulting in cavitation at this target point

A medical device system is provided herein which has an elongated, flexible hollow member with an expandable infusion segment attached at the most distal end of the device. The device has a plurality of fluid infusion ports on the expandable infusion segment for delivering an intended fluid to a target site in a body lumen. Additionally, a method is provided herein for infusing an intended fluid to a target site within a body lumen.

A medical device and collection method are disclosed which can effectively aspirate and remove substances collected inside a filter, and prevent the collected substances from dropping down from a filter portion. The collection method includes inserting a medical device having a filter portion in a contracted state into the living body lumen, installing the filter portion in the living body lumen by bringing the filter portion into the expanded state; collecting the substances inside the living body lumen using the filter portion; inserting an aspiration catheter which applies an aspiration force to a distal opening via a lumen formed inside the aspiration catheter, into the living body lumen along the shaft portion, and fitting the distal opening into the concave portion of the filter portion; aspirating the substances collected inside the concave portion using the aspiration catheter; and removing the filter portion from the inside of the living body lumen.

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

A method is disclosed for collecting substances inside a living body lumen using a medical device having an elongated shaft, a filter portion, and a support portion. The method includes inserting the medical device into the living body lumen; inserting an atherectomy device through the elongated shaft of the medical device; scraping a substance with the atherectomy device; collecting the substance using the filter portion of the medical device; and aspirating the substance by an aspiration catheter while the aspiration catheter is moved forward and rearward relative to the filter portion inside the filter portion.

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measurable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Systems and methods for removing plaque from blood vessels by applying constant or time varying magnetic or electrical fields. In one embodiment a system includes winding configurations positioned about a central axis along which a body region may be placed. Each winding configuration generates a magnetic field in a direction which passes through the body region. A first winding configuration generates a first magnetic field component perpendicular to a second magnetic field component generated by a second winding configuration. In a related method for removing a deposit of plaque from a position along a wall of a blood vessel a magnetic field is applied which has a net direction predominantly orthogonal to the direction of the flow of blood through the vessel.

Aspects of disclosed embodiments relate to systems, devices and methods for treating and preventing restenosis by cross-linking collagen fibrils of the vessel wall at the intervention site. The devices described are drug-eluting devices comprising: an expandable member or a balloon; a cross-linking agent; and a photoactivating light source. Upon the inflation of the expandable member or the balloon the cross linking agent is released and photoactivated in a therapeutically effective amount for cross-linking collagen fibrils.

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.