This disclosure disclosed an ultrasonic needle and apparatus used for removal of the vitreous body and other tissues. An ultrasonic vitrectomy needle, comprising: a connector, a connected inner needle, and an outer sheath. The length of the outer sheath at the distal end is slightly longer than that of the inner needle; the sheath distal end is of blind with smooth surface, but there is an open cut at the side of the distal end used for aspirating the vitreous body. The benefits of this disclosure: due to the difficulty if not impossible in the prior arts making a slim long center bore needle for ultrasonic surgical system, this disclosure clears the way to make the ultrasonic vitrectomy a practical reality; the ultrasonic vibration inherent advantages of the quietness, minuscule displacement, liquid repulsion and viscosity reduction improve safety of the surgery; the possibility of integrating ultrasonic vitrectomy and ultrasonic phaco emulsification procedures simplifies the complexity from prior arts, thus brings ease to the ophthalmic surgeries and reduces the cost.

Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This broadly focused probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.

The invention relates to a method for the non-invasive fragmentation of residual biomaterial after bone augmentation, and to a device specifically adapted for said method.

A probe unit includes, a probe configured to treat a bone by ultrasonic vibration, a hollow sheath which surrounds the probe and which has a first portion at a small distance from a central axis, and a second portion at a greater distance from the central axis than the first portion, and a knob configured to rotate the sheath relative to the probe between a first position for insertion between the bone and a living tissue facing the bone so that the first portion is located between the bone and the living tissue and a second position for insertion between the bone and the living tissue so that the second portion is located between the bone and the living tissue.

Methods and devices that provide enhanced delivery of a composition to a body region of a patient utilizing radiofrequency energy include directing a first electrode and a second electrode coupled to a radiofrequency energy source to a location proximate to the body region. Radiofrequency energy is provided in modulated pulses from the radiofrequency energy source to the body region from at least one of the first electrode and the second electrode to provide a delivery condition configured to enhance delivery of the composition. The composition is delivered proximate to the body region using a composition delivery element. Devices for enhance composition delivery are also disclosed.

Catheterization is carried out by inserting a probe into a cavity in a body of a subject. The probe has a contact force, a transmitter, a receiver, and an ultrasound transducer in its distal segment, After navigating the probe into contact with a target in a wall of the cavity, using the contact force sensor a desired contact force is established and maintained between the probe and the target. Responsively to readings by the receiver of signals from the transmitter, the distal end of the probe is oriented orthogonally to the target.

Catheterization is carried out by inserting a probe into a cavity in a body of a subject. The probe has a contact force, a transmitter, a receiver, and an ultrasound transducer in its distal segment, After navigating the probe into contact with a target in a wall of the cavity, using the contact force sensor a desired contact force is established and maintained between the probe and the target. Responsively to readings by the receiver of signals from the transmitter, the distal end of the probe is oriented orthogonally to the target.

Methods and devices that provide enhanced delivery of a composition to a body region of a patient utilizing radiofrequency energy include directing a first electrode and a second electrode coupled to a radiofrequency energy source to a location proximate to the body region. Radiofrequency energy is provided in modulated pulses from the radiofrequency energy source to the body region from at least one of the first electrode and the second electrode to provide a delivery condition configured to enhance delivery of the composition. The composition is delivered proximate to the body region using a composition delivery element. Devices for enhance composition delivery are also disclosed.

This disclosure disclosed an ultrasonic needle and apparatus used for removal of the vitreous body and other tissues. An ultrasonic vitrectomy needle, comprising: a connector, a connected inner needle, and an outer sheath. The length of the outer sheath at the distal end is slightly longer than that of the inner needle; the sheath distal end is of blind with smooth surface, but there is an open cut at the side of the distal end used for aspirating the vitreous body. The benefits of this disclosure: due to the difficulty if not impossible in the prior arts making a slim long center bore needle for ultrasonic surgical system, this disclosure clears the way to make the ultrasonic vitrectomy a practical reality; the ultrasonic vibration inherent advantages of the quietness, minuscule displacement, liquid repulsion and viscosity reduction improve safety of the surgery; the possibility of integrating ultrasonic vitrectomy and ultrasonic phaco emulsification procedures simplifies the complexity from prior arts, thus brings ease to the ophthalmic surgeries and reduces the cost.

An apparatus includes a generator including a control module that is operably coupled to a power module. The power module is configured to produce an electronic signal to be received by an ultrasonic energy delivery assembly. The ultrasonic energy delivery assembly is characterized by a natural frequency, and the electronic signal is characterized by a frequency. The control module is configured to send a control signal to the power module to randomly vary the frequency of the electronic signal within a range defined at least in part by the natural frequency.