An obstruction removal device is described having a variable external profile shape comprising one or more smaller profile regions and one or more larger profile regions.

A clot retrieval system includes a delivery catheter defining a lumen and having proximal and distal ends. An elongate shaft has proximal and distal ends and is configured for receipt within the delivery catheter. An inverted sleeve has a closed end attached to a distal segment of the elongate shaft and an open end. An outer section of the inverted sleeve that includes the open end is folded over onto an inner section of the inverted sleeve that includes the closed end at a rolling fold. An expansion device is supported on the elongate shaft at an axial location proximally spaced from the closed end and aligned with or distally spaced from the open end. The expansion device is configured for radially expanding the open end of the inverted sleeve.

The apparatus includes a catheter having a combined infusion/aspiration lumen, a three lumen proximal portion and a two lumen distal portion. An infusion/aspiration valve located at the distal end of the catheter facilitates performing infusion and aspiration through the same lumen, which in turn reduces the number of lumens, and enables the combined infusion/aspiration lumen to be made larger without the need to increase the diameter of the catheter. Differing material properties in the proximal and distal portions of the catheter enable the proximal portion to be made stiffer for pushability, while the distal portion is more flexible to navigate tortuous vasculature and enable a greater amplitude agitator to be received within the catheter.

A system may include an introducer sheath including a retention member configured to anchor the introducer sheath in a natural body lumen having a wall. The system may also have an elongate member extending along a longitudinal axis through a working channel of the introducer sheath. Additionally, the system may have a manipulating portion coupled to a distal end of the elongate member. The manipulating portion may include at least one selectively actuatable member configured to transition between an undeployed configuration and a deployed configuration. In the undeployed configuration, the at least one actuatable member may extend substantially parallel to the longitudinal axis and in at least one position in the deployed configuration, the at least one actuatable member may extend radially outwardly from the longitudinal axis. In the deployed configuration, the manipulating portion and elongate member may be configured to be proximally retracted toward the working channel of the introducer sheath so as to move a distal portion of the wall towards a proximal portion of the wall.

A medical device configured to perform an endovascular therapy can include an elongate manipulation member and an intervention member. The elongate manipulation member can include a distal end portion. The intervention member can include a proximal end portion and a mesh. The proximal end portion can be coupled with the distal end portion of the elongate manipulation member. The mesh can have a plurality of cells in a tubular configuration and being compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and being self-expandable from the collapsed configuration to an expanded configuration. The mesh can include an anodic metal and a cathodic metal. The anodic metal and the cathodic metal can each form a fraction of a total surface area of the mesh.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

Apparatus and methods are provided for delivering fluid into a body lumen during a medical procedure. A distal end of an apparatus may be introduced into a body lumen, and a valve on the distal end may be opened to deliver fluid through a first lumen into the body lumen, e.g., contrast and/or other diagnostic or therapeutic agents. The valve may be closed, and a procedure may be performed within the body lumen, e.g., using a treatment element carried on the distal end. For example, the treatment element may include a balloon that may be inflated when fluid is delivered through the first lumen with the valve closed. Optionally, a prosthesis, energy source, drug platform, and the like may be carried by the balloon for treating the body lumen. In various embodiments, the valve may be located proximal or distal to the treatment element.

In embodiments of an obstruction removal device, system, and/or method, an expandable member is configured to be slidably coupled to a guide wire. The expandable member is configured to surround at least a portion of an obstruction captured by a stentriever as the expandable member transitions from the expanded state to the contracted state, i.e., when the guide wire is removed from a vasculature to remove the stentriever and the obstruction from the vasculature. A first locking member is located at a base of the expandable member. The first locking member is configured to engage a second locking member that is located on the guide wire, the stentriever, or an inner surface of a guide catheter, thereby coupling the expandable member to the guide wire, the stentriever, or the inner surface of the guide catheter when the expandable member is deployed within the vasculature.

A neurovascular catheter having an atraumatic navigational tip is disclosed. The catheter includes an elongate flexible tubular body, a distal zone of the tubular body comprising: a tubular inner liner; a helical coil surrounding the inner liner and having a distal end, a tubular jacket surrounding the helical coil, and extending distally beyond the helical coil distal end to terminate in a catheter distal face, and a tubular radiopaque marker embedded in the tubular jacket. The catheter distal face comprises a first section that resides on a first plane which crosses a longitudinal axis of the tubular body at a first angle within the range of from about 35 degrees to about 55 degrees, and a second section that resides on a second plane which crosses the longitudinal axis of the tubular body at a second angle within the range from about 55 degrees to about 90 degrees.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to a medical device. The device can include an elongate core member having a distal portion configured to be intravascularly positioned at a treatment site within a blood vessel lumen, and an interventional element connected to the distal portion of the elongate core member. The interventional element includes a body that is expandable from a first configuration to a second configuration and an electrically conductive radiopaque marker coupled to the body. An electrically conductive lead has a distal portion electrically coupled to the radiopaque marker and a proximal portion configured to be electrically coupled to a current source.