Devices, systems, and methods for delivering a substance within a mammalian luminal organ or area adjacent thereto. In at least one exemplary embodiment of a system of the present disclosure, the system comprises an inner delivery device, comprising an inner portion configured to receive a substance therein, a pock tip at or near a distal end of the inner delivery device, the pock tip configured to deliver the substance from the inner portion, through a pock tip aperture defined within the pock tip, and into a mammalian tissue and/or luminal organ, and an embolus positioned within the inner portion, the embolus configured so that the substance remains distal to the embolus when the substance is positioned within the inner portion. In another embodiment, the system further comprises an outer catheter, comprising an elongate body, a guidewire lumen defined within the elongate body and configured to receive at least part of a guidewire therein, and a central lumen defined within the elongate body, the central lumen configured to receive at least a portion of the inner delivery device.

A balloon pulling device, comprising a core tube (11) portion and a balloon (12) portion, wherein the core tube (11) portion may inflate and deflate the balloon (12) portion by using a fluid; the present invention is characterized in that the balloon (12) portion comprises a plurality of expansion segments (13), the expansion segments (13) being larger than the remaining portion of the balloon (12) after being inflated with a fluid such that the entire balloon (12) forms a curved contour. A simple and reliable balloon pulling device capable of retracting at a long distance while being finely adjusted is achieved.

Described herein are shock wave devices and methods for the treatment of calcified heart valves. One variation of a shock wave device includes three balloons that are each sized and shaped to fit within a concave portion of a valve cusp when inflated with a liquid and a shock wave source within each of the three balloons. Each balloon is separately and/or independently inflatable, and each shock wave source is separately and/or independently controllable. Methods of treating calcified heart valves using a shock wave device can include advancing a shock wave device having one or more balloons and a shock wave source in each of the balloons to contact a heart valve, inflating the one or more balloons with a liquid such that the balloon is seated within a concave portion of a valve cusp, and activating the shock wave source.

One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.

Systems are provided for deploying a vascular prosthesis having at least one stent with an end portion configured to be introduced into a vessel and a sheath connected thereto. The systems include a first expandable balloon for shaping and stabilizing the vascular prosthesis in the vessel, a second expandable balloon for sealing a junction between the end portion of the vascular prosthesis and the vessel, and means for expanding the first and second expandable balloons.

One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.

Example embodiments relate to endoscopic systems. Endoscopic system includes main body and control section. Control section includes extendible section that extends and contracts to change length between extendible section ends. Control section includes first expandable member. When first expandable member is in an expanded configuration, first expandable member includes proximal side wall and distal side wall. Distal side wall of first expandable member includes first protrusions. Control section includes second expandable member. When second expandable member is in an expanded configuration, second expandable member includes distal side wall and proximal side wall. Proximal side wall of second expandable member includes second protrusions. First and second protrusions configurable to cooperate to form a sieve portion between first and second expandable members. The sieve portion configured to reduce an occurrence of solids blocking pressure openings while allowing negative pressure to be applied to a body cavity wall through the pressure openings.

Example embodiments relate to endoscopic systems. The system includes an outer assembly and main assembly. The outer assembly may include proximal and distal ends and outer anchor assembly. The outer anchor assembly may include a first expandable member and first outer pressure opening. The first expandable member may expand radially outwards. The main assembly may include proximal and distal ends and a navigation assembly. The navigation assembly may include an instrument, second expandable member, bendable section, extendible section, and first pressure opening. The extendible section may include proximal and distal ends. The proximal end of the extendible section may be secured in position relative to the distal end of the outer assembly. The extendible section may be configurable to extend and contract. The first main pressure opening may be configurable to apply a negative pressure.

Devices, systems, and methods for delivering a substance within a mammalian luminal organ or area adjacent thereto. In at least one exemplary embodiment of a system of the present disclosure, the system comprises an inner delivery device, comprising an inner portion configured to receive a substance therein, a pock tip at or near a distal end of the inner delivery device, the pock tip configured to deliver the substance from the inner portion, through a pock tip aperture defined within the pock tip, and into a mammalian tissue and/or luminal organ, and an embolus positioned within the inner portion, the embolus configured so that the substance remains distal to the embolus when the substance is positioned within the inner portion. In another embodiment, the system further comprises an outer catheter, comprising an elongate body, a guidewire lumen defined within the elongate body and configured to receive at least part of a guidewire therein, and a central lumen defined within the elongate body, the central lumen configured to receive at least a portion of the inner delivery device.

Described herein are shock wave devices and methods for the treatment of calcified heart valves. One variation of a shock wave device includes three balloons that are each sized and shaped to fit within a concave portion of a valve cusp when inflated with a liquid and a shock wave source within each of the three balloons. Each balloon is separately and/or independently inflatable, and each shock wave source is separately and/or independently controllable. Methods of treating calcified heart valves using a shock wave device can include advancing a shock wave device having one or more balloons and a shock wave source in each of the balloons to contact a heart valve, inflating the one or more balloons with a liquid such that the balloon is seated within a concave portion of a valve cusp, and activating the shock wave source.