Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.

A vertebral endplate preparation (decorticating) tool has height adjustable blades at a distal end of a shaft assembly for decorticating/shaving vertebral endplate material from spinal vertebrae, translates axial movement of a control rod of the shaft assembly of the vertebral endplate preparation tool with height adjustable blades into radial blade height change (extension and retraction) through a controller of a handle assembly. The blades may also be configured for collecting and removing shaved vertebral endplate material. The blades controllably move outward radially from the distal end of the shaft assembly and controllably move inward radially into the distal end of the shaft assembly upon manipulation of the controller. Radial blade extension and retraction from the distal end may be accomplished via mutual angled dovetail features of the blades and the distal end, or via pins of the distal end of the shaft assembly situated in angled slots of the blades.

A minimally invasive tissue incision system for creating joint capsulotomies and releasing/incising various tissues, tendons, and fibrous band structures is described. The system contains a penetrating needle which is retractable so as to expose a cutting element, and which may be used as a penetrating needle to pierce the skin and other soft tissue structures. The cutting element provided within the penetrating needle may be used to incise subsequent tissue structures after the initial penetration. The system facilitates such procedures by providing the cutting element with the confines of the needle which provides safe introduction of the cutting element directly to the site via the needle.

A treatment tool includes a tubular member including an opening and a tubular member main body that has a tubular shape. The tubular member is configured to suction a tissue piece through the opening. The treatment tool includes a blade member provided on an opening edge of the opening.

An integrated scope and biopsy device having visualization for use in many different medical applications, such as, but not limited to, collection of uterine tissue biopsy is disclosed. The device may further include an integrated camera and light for visualizing the interior of the uterus and the tissue biopsy site itself. Further, the device is configured to evacuate tissue biopsies through aspiration and irrigation.

A surgical access assembly and method of use is disclosed. The surgical access assembly comprises an outer sheath and an obturator. The outer sheath and obturator are configured to be delivered to an area of interest within the brain. Either the outer sheath or the obturator may be configured to operate with a navigational system to track the location of either within the brain. Once positioned at a desired location, the obturator is removed, leaving a distal end of the outer sheath adjacent an area of interest, and creating a working corridor. Interrogation of the area of interest may be performed to evaluate a disorder and/or abnormality, as well as evaluate treatment regimes. Interventional devices may also be introduced to the area of interest, as well as a variety of treatments.

An ultrasonic treatment instrument for use in arthroscopic surgery, includes a probe having a main body that is configured to transmit ultrasonic vibration, and a treatment portion that is provided on a distal side of the main body and is configured to cut a hard tissue and/or a soft tis e by transmission of the ultrasonic vibration; and a sheath unit that includes an inner sheath covering an outer peripheral surface of the main body in the probe, and an outer sheath covering an outer peripheral surface of the inner sheath and forming a suction path between the outer peripheral surface of the inner sheath and the outer sheath, wherein a distal end of the inner sheath extends to a position closer to the treatment portion of the probe than a distal end of the outer sheath.

Described herein are devices for cleansing the internal surface of various body cavities. The devices generally include a handle and one or more cleansing tips having different sets of cleansing surfaces. In addition to removing debris, and disrupting bacterial biofilms so as to make these bacteria more susceptible to various cleansing agents, the devices may be configured to deliver an antiseptic agent, an anti-inflammatory agent, or a fragrance to the body cavity surfaces, or deliver UV light to sanitize the surfaces. Methods for cleansing the surfaces of body cavities such as the nasal passages and vaginal cavity are also described herein. Systems including one or more cleansing devices and one or more cleansing formulations are further described.

Example embodiments of the systems and methods of callus removal disclosed herein comprise a callus catching function to catch the calluses removed by the blade. A clamp on the back side of the blade comprises a hollowed out section into which the blade deposits the removed calluses. The hollowed area may be formed, for example, by a clamp for holding the blade in a handle. In an example embodiment, the clamp may also comprise a pumice sponge for further use in pedicure processes. The clamp may be removable to allow for removal of the collected calluses into a collection bin.

A basket apparatus is described that assists in removing objects from within a patient. The apparatus includes a number of pull wires, each pull wire physically coupled to a different capstan that individually actuates one of the pull wires. The apparatus also includes an outer support shaft itself including a number of channels through which the pull wires traverse. The portions of the pull wires extending out of the outer support shaft form a basket of adjustable size, shape, and position. The pull wires are attached together at a tip located at a distal end of the basket apparatus. By controlling the actuation of the various pull wires, the basket's shape, position size can be manipulated to reposition the basket around an object located within a patient, independent of or in conjunction with motion of the remainder of the apparatus or an associated endoscope.