Provided are products of manufacture and methods for the removal and/or destruction of a biofilm in situ, e.g., a gastro-luminal biofilm, and for the treatment or amelioration of biofilm-associated diseases, infections and conditions, including and GI luminal infections. Provided are devices and apparatus, and methods for using them, for the removal, disruption and/or destruction of a biofilm in situ, e.g., a gastro-luminal biofilm. In alternative embodiments, provided are devices and apparatus, and methods, for enhancing biofilm dissolving or disrupting agents, or for administering biofilm dissolving or disrupting agents, where in alternative embodiments the biofilm comprises a gastro-luminal ‘unstirred layer’, adherent layer or gastro-luminal mucus layer; or the biofilm comprises a matrix or a DNA-containing layer, or alternatively the biofilm comprises a polysaccharide gastro-luminal peripheral layer.

A clot retrieval cleaning instrument can have bristles, fluid sprays, or other techniques to liberate captured clot material from a clot retrieval device so that it can be reinserted into a patient's vasculature for successive capture attempts. The cleaning instrument can be conveniently integrated or connected to a hemostasis valve assembly so that the cleaning function can be performed without completely removing the clot retrieval device from the delivery system. Aspiration can be applied to remove the freed thrombus material. The cleaning instrument can be removable from the delivery system to facilitate the instrument's washing or disposal.

A surgical tool comprises a dilator, a cutter, a retractable brush, and at least one retractable drill. The dilator is configured to dilate tissue of a patient and can be positioned in an undilated configuration or a dilated configuration. The cutter is configured to cut the tissue and is disposed at a distal end of the dilator. The cutter is configured to move between a cutting position when the dilator is in the undilated configuration and a non-cutting position when the dilator is in the dilated configuration. The retractable brush is configured to brush a surface of an anatomical element of the patient to remove matter from the surface. The at least one retractable drill is configured to drill into the anatomical element.

A medical probe for traversing a tract in the body of a human or animal. One medical probe includes an elongate elastically deformable member including a helically wound element, and a sheath having an inner surface which contacts an outer surface of the elastically deformable member. The probe is elastically deformable, for traversing the tract, by virtue of the elastically deformable member. The probe may include a treatment element, which can be used to perform a procedure in the body of a patient. An assembly includes a probe and a treatment element. The medical probe has a particular use in the treatment of a fistula, in which the probe takes the form of a fistula probe adapted to traverse a fistula tract.

A lymphangiogenesis inducing device includes: a puncture member including a distal end portion configured to puncture living tissue, and a through hole penetrating the puncture member along a central axis and extending from the distal end portion toward a proximal end; and a rod-shaped body inserted into the through hole and configured to be moved so as to protrude from the distal end portion. The rod-shaped body includes a shaft portion, and a wound imparting structure including at least one protrusion located on the shaft portion and configured to impart a wound to the living tissue.

Methods and apparatuses for performing an orthopedic procedure in the sacroiliac region are disclosed. In one form, an aperture is formed that at least partially extends through at least one of an ilium and a sacrum. An undercutting system is inserted into the aperture. The undercutting system may include an insertion apparatus, a probe assembly, and a cutting assembly. The probe assembly is moved with respect to the insertion apparatus from a retracted position to an extended position. The probe assembly is manipulated within a joint between the ilium and the sacrum while the probe assembly is in the extended position. The cutting assembly is moved with respect to the insertion apparatus from a retracted position to an extended position. The cutting assembly is manipulated within the joint between the ilium and the sacrum while the cutting assembly is in the extended position to form a fusion region.

The invention relates to a skin treatment device for removing callus from the skin by an abrasive treatment, comprising a housing with a handle section (110), a skin treatment element (120) rotatable around a rotational axis (101) and a protective rim (130). Said protective rim circumferentially encases said skin treatment element partially over an angular range of more than 120° and less than 330° about said rotational axis such that a circumferential abrasive treatment surface protrudes from the protective rim in an area extending over an angular range of 30° to 240°.

A vacuum motor has a piston that linearly oscillates in the internal space of a housing. A gas outlet and a gas inlet (supplying ambient air) located in the housing terminate in the space between the piston and the housing rear side. The piston never covers the outlet or inlet. A valve body closes the inlet. A pestle moves within the housing between the piston and valve body. When the piston moves toward the rear side of the space, the valve body moves against the force of a spring and opens the inlet. The free cross-section of the opened inlet is at least equal in size to the free cross-section of the outlet. A surgical drive system, a medical lavage system, and a medical device for brushing, rasping or sawing of tissue or bone—all include the vacuum motor. Also disclosed is a method for operating the vacuum motor.

An apparatus for disrupting tissue in the intervertebral disc space that includes a barrier member having a first configuration for insertion into the disc space and a second configuration when deployed within the disc space. The second configuration of the barrier member is adapted to at least partially define a perimeter of a working region within the disc space. The apparatus also includes a tissue disruption tool configured for insertion into the working region.

High torque guidewires and methods for making and using them are provided. A guidewire may include an inner core wire movable relative to an outer jacket. The outer jacket includes proximal and distal ends, a lumen extending there between, thereby defining a longitudinal axis, and one or more helical slots adjacent the distal end. The core wire includes a proximal portion, a distal portion slidably received in the outer jacket lumen and terminating in a curved distal tip that extends from the outer jacket distal end, and one or more pins on the distal portion, each pin slidably received in a respective helical slot in the outer jacket such that axial movement of the core wire relative to the outer jacket causes the pin to slide within the helical slot and rotate the distal tip relative to the outer jacket distal end.