The present technology is directed generally to devices, systems, and methods for capturing and cutting fibrous and trabeculated structures (such as synechiae) in vessel lumens. In one embodiment, the present technology includes an intraluminal tissue modifying system configured to capture the fibrous structures, put the fibrous structures in tension, and controllably cut through the fibrous structures without applying appreciable additional force to the vessel wall. The system may include an expandable capture device and a cutting device.

A biopsy device for acquiring a tissue sample is disclosed. The biopsy device comprises a partoff mechanism which can have at least a tab and an actuator. The actuator can be used to control the angle of the tab and thus partoff a tissue sample. The tab may be on a cutter tube, which may have a sharp distal end which may core the samples from the mass of tissue. Multiple tissue samples may be collected.

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

An enhanced trocar for laparoscopic surgery has a proximal end, a distal end, and a tubular trocar body connecting and extending between the ends. The trocar body is shaped and sized to receive inline and retain therein tissue isolated and divided during a laparoscopic surgical procedure, to permit a surgeon to remove such tissue from the surgical site and dispose of the removed tissue without an additional dedicated disposal device.

Exemplary embodiments of method and apparatus are provided for damaging and/or removing portions of subcutaneous fatty tissue while leaving the overlying dermal layer of the skin substantially undamaged. One or more hollow needles can be provided that include an arrangement within the lumen configured to retain or damage portions of fatty tissue that enter the lumen. Properties of the needle can be selected such that the needle can be inserted into skin and pass through the dermal layer, allowing fatty tissue to enter the distal portion of the lumen as it is advanced further, and then leaving the dermis undamaged when withdrawn. Such exemplary apparatus can include a plurality of such needles, a reciprocating arrangement to mechanically advance and withdraw the one or more needles, and/or a vibrating arrangement.

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

An apparatus with a deployable blade for probing and cutting can include an elongate member having a probe and a blade associated with a first end thereof. The probe can include a target interaction surface that is selectively movable between a retracted state and a target acquisition state. The blade includes a cutting edge and is selectively movable between a retracted position and an extended position. The handheld apparatus may additionally include a manually operated control that is operably connected to the probe and/or the blade to cause the retraction/extension of the probe and/or blade.

An atherectomy system includes an atherectomy burr having one or more blood flow enhancement features that permit an increased level of blood flow past the burr relative to a blood flow that would result absent the one or more flow enhancement features. A drive mechanism is adapted to rotatably actuate the atherectomy burr.

A surgical instrument includes a hollow member having a sidewall provided with a window and a closure member movably connected to the hollow member for alternately covering and uncovering the window. The hollow member has a first clamping surface along an edge of the window, while the closure member has a second clamping surface opposing the first clamping surface and disposable substantially adjacent thereto in a clamping or closure configuration of the instrument. The instrument additionally comprises a tissue occlusion component mounted to at least one of the hollow member and the closure member for acting on tissues gripped between the first clamping surface and the second clamping surface, to couple the tissues to each other.