A method of delivering a drug in a vessel includes positioning an inflatable balloon that is located at a distal end of an ultrasonic device within a lumen of the vessel, the inflatable balloon being deflated and coated with at least one drug; inflating the inflatable balloon; and transmitting a vibration to the distal end of the ultrasonic device to dislodge the drug from the inflated inflatable balloon and deliver the drug to an interior portion of the vessel.

A surgical instrument includes a shaft, an ultrasonic transducer, a waveguide acoustically coupled with the ultrasonic transducer and extending distally through the shaft, and an end effector arranged at a distal end of the shaft. The end effector includes an ultrasonic blade acoustically coupled with the waveguide, a clamp arm movable relative to the ultrasonic blade for clamping tissue, and an RF electrode operable to seal tissue with RF energy. The ultrasonic transducer is operable to drive the waveguide and the ultrasonic blade with ultrasonic energy. The surgical instrument further includes an ultrasonic electrical circuit operable to energize the ultrasonic transducer, and an RF electrical circuit operable to deliver RF energy to the RF electrode. A return path of the ultrasonic electrical circuit and a return path of the RF electrical circuit pass through a shared electrically conductive element.

The present invention provides methods and devices for treating endovascular disease. Vibrational energy is delivered to change compliance and increase permeability at the treatment area. To improve clinical outcomes, one or more therapeutic drugs may be delivered to the treatment area.

A surgical system includes a surgical instrument having a body, an ultrasonic transducer, a shaft extending distally from the body, and an end effector at a distal end of the shaft and being operable to treat tissue with ultrasonic energy. An accessory device is configured to operatively couple the surgical instrument with a generator operable to power the surgical instrument to provide ultrasonic energy. A primary EEPROM is provided within the instrument body and is operable to track usage of the surgical instrument. The system further includes at least one of: an accessory EEPROM integrated into the accessory device and being operable to track usage of the accessory device; a transducer EEPROM integrated into the ultrasonic transducer and being operable to track usage of the ultrasonic transducer; or an ASIC integrated into the accessory device and being operable to communicate with the generator regarding a state of the surgical instrument.

A surgical instrument has a first modular assembly and a second modular assembly. The first modular assembly has a body, an ultrasonic waveguide, an ultrasonic blade connected to a distal end of the ultrasonic waveguide, and a coupling member that movably couples with the body. The second modular assembly has a clamp arm assembly with a first pivot coupling, a clamp pad assembly with a second pivot coupling, and a distal outer sheath that selectively couples to the body of the first modular assembly via the coupling member. The distal outer sheath has an interior surface that houses a portion of the ultrasonic waveguide, and this interior surface also houses the first pivot coupling and the second pivot coupling.

A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

A surgical instrument includes a transducer configured to produce vibrations at a predetermined frequency. An ultrasonic end effector extends along a longitudinal axis and is coupled to the transducer. The ultrasonic end effector comprises an ultrasonic blade and a clamping mechanism. A controller receives a feedback signal from the ultrasonic end effector and the feedback signal is measured by the controller. A lumen is adapted to couple to a pump. The controller is configured to control fluid flow through the lumen based on the feedback signal, and the lumen is located within the ultrasonic end effector.

A probe configured to be connected to a transducer unit configured to generate ultrasonic vibration, includes an elongated vibration transmission portion configured to transmit the ultrasonic vibration; and an engagement member provided on and/or near an outer circumference at a position which becomes a node of the ultrasonic vibration when the ultrasonic vibration is transmitted to the vibration transmission portion, the engagement member being formed by a material of an identical to or smaller damping rate than a damping rate of the ultrasonic vibration in the vibration transmission portion, and the engagement member being engaged with an exterior member disposed on an outer side of the vibration transmission portion.

Disclosed is an ultrasonic surgical system, comprising: an ultrasonic transducer used for converting an alternating current signal into vibration; and an ultrasonic amplitude transformer used for amplifying the amplitude of the vibration generated by the ultrasonic transducer, wherein the product L.sub.1×C.sub.1 of a dynamic equivalent inductance L.sub.1 and a dynamic equivalent capacitance C.sub.1 of the ultrasonic surgical system in a no-load state and the product L′×C′ of a dynamic equivalent inductance L′ and a dynamic equivalent capacitance C′ of the ultrasonic surgical system in an on-load state satisfy the relational expression

[00001]$.Math.1-\frac{\sqrt{L_1\times C_1}}{\sqrt{L^{\prime }\times C^{\prime }}}.Math.=\alpha ,$

such that a resonance frequency f.sub.s of the ultrasonic surgical system in the no-load state and a resonance frequency f.sub.s′ thereof in the on-load state satisfy the relational expression

[00002]$.Math.1-\frac{f_s^{\prime }}{f_s}.Math.=\alpha ,$

wherein a is less than or equal to 0.1%, and preferably α is less than or equal to 0.05%.

A treatment device includes: an end effector that includes a pair of grippers for gripping a target region; a channel for supplying a fluid to the end effector; and a fluid source for supplying the fluid to the channel. The treatment device is capable of controlling fluid flow to the end effector based on an open or closed state of the end effector