Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.

Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.

The present subject matter discloses a device and system of aspirating follicular fluid. In an example, an ovum pick up (OPU) device for aspirating follicular fluid includes a needle having a first end and a second end, opposite to the first end. The first end of the needle is to pierce through an ovarian follicle to aspirate the follicular fluid from the ovarian follicle by a suction force. The OPU device includes a connector having a channel to receive the second end of the needle. The OPU device further includes an elastic tube connected to the connector. The second end of the needle passes through the channel and inside the elastic tube. The elastic tube is compressible, while locating the ovarian follicle and piercing the needle through the ovarian follicle, to regulate the suction force during aspiration of the follicular fluid between two follicles.

The present subject matter discloses a device and system of aspirating follicular fluid. In an example, an ovum pick up (OPU) device for aspirating follicular fluid includes a needle having a first end and a second end, opposite to the first end. The first end of the needle is to pierce through an ovarian follicle to aspirate the follicular fluid from the ovarian follicle by a suction force. The OPU device includes a connector having a channel to receive the second end of the needle. The OPU device further includes an elastic tube connected to the connector. The second end of the needle passes through the channel and inside the elastic tube. The elastic tube is compressible, while locating the ovarian follicle and piercing the needle through the ovarian follicle, to regulate the suction force during aspiration of the follicular fluid between two follicles.

A core member for semen collection device includes a flexible body and a built-in piece. The flexible body has a flexible base and an annular sidewall extending from the flexible base to form the cylindrical structure. The built-in piece is disposed in the sidewall of the flexible body. The built-in piece is made of a hard resin material, and the flexible body defines the insertion space having the inlet at the end of the flexible body.

An intravaginal conception assistance device for collecting and presenting ejaculate relatively close to a cervix. The device has a cup part for collecting the ejaculate present in a vaginal canal and presenting it relatively close to the cervix upon moving through the vaginal canal towards the cervix. The cup part is substantially invertible. The cup part can be brought from a first, substantially non-inverted state into a second, substantially inverted state in which the cup part has been folded substantially inside out. As a result, insertion of the cup part into the vaginal canal can be facilitated.

An intravaginal conception assistance device for collecting and presenting ejaculate relatively close to a cervix. The device has a cup part for collecting the ejaculate present in a vaginal canal and presenting it relatively close to the cervix upon moving through the vaginal canal towards the cervix. The cup part is substantially invertible. The cup part can be brought from a first, substantially non-inverted state into a second, substantially inverted state in which the cup part has been folded substantially inside out. As a result, insertion of the cup part into the vaginal canal can be facilitated.

Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

Devices and methods for vaginal insertion are disclosed.