The disclosed technology includes couplers, nose pieces, and strain relief hubs for ablation catheter assemblies and methods of using the same. The disclosed technology can include a medical probe having a coupler having a first portion, a second portion, and a vent port. The second portion can slide between a first position and a second position. When in the first position, the vent port can be at least partially obstructed by the first portion and, when in the second position, the vent port can be unobstructed by the first portion. The medical probe can include a nose piece having an outer diameter of less than 0.14 inches and an aperture extending therethrough. The aperture can be sized to receive a catheter. The medical probe can include a strain relief hub having a first portion and a second portion and configured to be coupled to a handle of the medical probe.

Flexible circuit strips of a catheter balloon may comprise a substrate and a contact electrode disposed on the substrate. A cover may be disposed over a peripheral portion of the contact electrode and an adjacent portion of the substrate The cover is intended to increase robustness of the contact electrode in response to fatigue that might arise from repeated expansion and contraction of the catheter balloon.

A catheter balloon comprises an ellipsoidal membrane. A plurality of flexible circuit strips, each of which comprises a substrate and a contact electrode, are disposed about the membrane. A coating is disposed atop at least the outer surface of the membrane and may also be disposed atop a portion of each of the substrates. The coating may comprise a dielectric material, such as parylene. The coating may increase the smoothness of the balloon. When subject to internal pressures that expand the balloon, the coating may also increase the resilience of the balloon relative to a balloon that lacks the coating as determined by changes in the balloon's diameter before and after expansion.

A medical device includes a guidewire extending between a proximal portion defining a proximal end and a distal portion defining a distal end. The distal portion includes a radially expandable part, and the guidewire is movable between a retracted configuration in which the part is radially retracted and an expanded configuration in which the part is radially expanded. The part is radiopaque.

Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.

A device for performing a surgical procedure includes an elongated shaft extending between a proximal end and a distal end. The shaft includes an outer surface and an inner surface. An expandable member is disposed at the distal end of the shaft. The expandable member is configured to receive inflation material. At least one electrode is disposed with the inflatable member. Methods of use are disclosed.

The various embodiments described herein provide devices and methods for neuroablation in the tympanic cavity. Devices include an ablation effector that can be navigated into the tympanic cavity to ablate nerves therein in order to treat diseases caused due to the malfunction of these nerves.

A catheter system (100) for treating a vascular lesion (106A) within or adjacent to a vessel wall (108A) within a body (107) of a patient (109). The catheter system (100) includes a light source (124), a receptacle assembly (274), a first light guide (122A) and a second light guide (122A), a multiplexer (128), and an alignment assembly (256). The light source (124) generates a source beam (124A) of light energy. The first light guide (122A) and the second light guide (122A) are coupled to the receptacle assembly (274), each light guide (122A) having a guide proximal end (122P). The multiplexer (128) receives the source beam (124A) from the light source (124), the multiplexer (128) directing individual guide beams (124B) from the source beam (124A) to each of the guide proximal end (122P) of the first light guide (122A) and the guide proximal end (122P) of the second light guide (122A). The alignment assembly (256) adjusts the position of the receptacle assembly (274) relative to the individual guide beams (124B).

A system for use in a renal denervation procedure includes a catheter having proximal and distal end portions, a sensor configured to sense a condition of one or more nerves, the sensor operatively associated with the distal end portion of the catheter, and at least one electrode disposed on the distal end portion of the catheter for delivering energy to renal tissue. A catheter includes a catheter body defining a distal end portion and a proximal end portion, and a sensor for sensing a renal sympathetic nerve, the sensor disposed on the distal end portion of the catheter body, wherein the sensor is configured to sense an electromagnetic signal from the renal sympathetic nerve.

An ablation catheter including an elongate shaft, an inflatable balloon positioned at a distal region of the elongate shaft, a first ablation electrode disposed outside of and carried by an outer surface of the inflatable balloon, a first ultrasound transducer disposed outside of the inflatable balloon, and a flexible circuit. The flexible circuit includes a first conductor and a second conductor and is disposed outside of and carried by the outer surface of the inflatable balloon. The first conductor is in electrical communication with the first ablation electrode, and the second conductor in electrical communication with the first ultrasound transducer.