A system for use with performing a medical procedure is provided which comprises a balloon catheter and a processing device. The balloon catheter comprises a plurality of ablation electrodes configured to ablate tissue of patient anatomy, a stem electrode and an edge electrode. The processing device comprises a processor configured to acquire first impedance measurements between each of the ablation electrodes of the balloon catheter and an edge electrode of the balloon catheter, acquire second impedance measurements between each of the ablation electrodes of the balloon catheter and a stem electrode of the balloon catheter, determine, during ablation of the tissue, changes to at least one of the first and second impedance measurements, and indicating lesion formation based on the changes to at least one of the first and second impedance measurements.

A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (108A) of a blood vessel (108) within a body (107) of a patient (109) includes an energy source (124), a catheter fluid (132), and an emitter assembly (129). The energy source (124) generates energy. The emitter assembly (129) includes (i) at least a portion of an energy guide (122A) having a guide distal end (122D) that is selectively positioned near the treatment site (106), (ii) a plasma generator (133), and (iii) an emitter housing (260) that is secured to each of the energy guide (122A) and the plasma generator (133) to maintain a relative position between the guide distal end (122D) of the energy guide (122A) and the plasma generator (133). The energy guide (122A) is configured to receive energy from the energy source (124) and direct the energy toward the plasma generator (133) to generate a plasma bubble (134) in the catheter fluid (132). The plasma generator (133) directs energy from the plasma bubble (134) toward the treatment site (106).

A radio frequency ablation device (300) comprising a balloon blocking catheter. The radio frequency ablation device (300) comprises a double or multi-lumen balloon blocking catheter (310) and a radio frequency ablation catheter (320). a stent (321) is arranged at the far end of the radio frequency ablation catheter (320). Two or more electrodes (322, 325, 326) are arranged on the stent (321), and are connected to a radio frequency generator respectively by means of the corresponding guide wires arranged in the radio frequency ablation catheter (320). When the radio frequency ablation device (300) is used for ablating blood vessel peripheral nerves, inflating a blocking balloon (311) arranged at the far end of the guide catheter (310) to block local blood flow in a blood vessel. The invention has ideal nerve ablation effect.

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.

Cystic lesions can be treated by electroporation. For example, this document describes methods and devices for endoscopic ultrasound-guided ablation of cystic lesions using a needle for electroporation.

A catheter system and method for treating a treatment site within or adjacent to a vessel wall or a heart valve within a body of a patient includes an energy source, an inflatable balloon, an energy guide, and an acoustic sensor. The inflatable balloon is positionable substantially adjacent to the treatment site. The inflatable balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy guide receives energy from the energy source and guides the energy into the balloon interior. The acoustic sensor is positioned outside the body of the patient. The acoustic sensor senses acoustic sound waves generated in the balloon fluid within the balloon interior. The acoustic sensor generates a sensor signal based at least in part on the sensed acoustic sound waves.

Medical devices and methods for making and using the same are disclosed. An medical device may include a medical device for renal nerve ablation. The medical device may include a catheter shaft having a distal region. An expandable balloon may be coupled to the distal region. An electrode assembly may be coupled to the balloon. The electrode assembly may include a first electrode pad including one or more electrodes. The first electrode pad may have a first lead-in edge, a first protruding edge, and a first transition region with a continuously changing curvature disposed between the first lead-in edge and the first protruding edge.

A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.