The present invention relates to a TIPS stent graft, comprising a tubular component having a lumen extending therethrough, the tubular component comprising a balloon expandable central section and a first and a second self-expanding section, the first and the second self-expanding section sandwiching the central section, the lumen extending through the first, central, and second sections, the stent graft being capable of selectively constricting the central section.

Provided herein is an apparatus having a first tubular body, a second tubular body disposable within the first tubular body, a first plurality of fenestrations in fluid communication with a gallbladder lumen, and an expandable body disposed around the first plurality of fenestrations. The first plurality of fenestrations is configured to deliver a phase changing ablation medium by spraying the phase changing ablation medium in a spatially diffuse pattern into the space defined by the expandable body between the first plurality of fenestrations and the wall of the gallbladder. The first tubular body and the second tubular body define an annular flow path. A pressure sensor measures intraluminal pressure of the gallbladder. A control unit is coupled to the pressure sensor.

Devices, systems, and methods for treating cardiac arrhythmia are disclosed herein. In some embodiments, devices, systems, and methods disclosed herein deliver interrogating energy to tissue at a position on a wall of an anatomical structure of a patient. If the devices, systems, and methods disclosed herein detect a change in electrical activity of the anatomical structure in response to the interrogating energy, the devices, systems, and methods disclosed herein can apply irreversible therapy to the tissue. In some embodiments, the change in electrical activity corresponds to slowing or termination of a detected arrhythmia

A method includes receiving: (i) a position of a target tissue intended to be ablated in an organ of a patient and having a predefined pattern, and (ii) an energy level of an ablation signal intended to be applied to the target tissue. One or more selected ablation electrodes that, when applying the ablation signal, produce together a lesion having a shape that covers the predefined pattern, are selected in a catheter that is inserted into the organ and has an array of ablation electrodes. In response to verifying that: (i) the one or more selected ablation electrodes are positioned on the target tissue, and (ii) a contact force between the one or more selected ablation electrode and the target tissue is larger than a force threshold, the ablation signal is applied to the target tissue using the one or more selected ablation electrodes.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

A system for performing a medical procedure on mucosal tissue in an intestine of a patient is provided. The system including a catheter a catheter for insertion into the intestine, and a console. The catheter comprises: a shaft including a distal portion, and a functional assembly on the distal portion of the shaft. The functional assembly is configured to receive fluid. The console comprises: at least one pumping assembly configured to deliver the fluid to the functional assembly; and a connector configured to operably attach the catheter to the console. The functional assembly is configured to treat target tissue of the intestine of the patient. Methods of treating intestinal mucosal tissue are also described.

Systems, apparatus, and methods are described for treatment of varicocele and associated conditions. In some embodiments, systems, apparatus, and methods described herein can include forming one or more fluid connections or fistulas between blood vessels such as a gonadal vein (e.g., spermatic vein, ovarian vein) and surrounding veins. In some embodiments, systems, apparatus, and methods described herein can include occluding one or more blood vessels such as a gonadal vein (e.g., spermatic vein, ovarian vein). In some embodiments, systems, apparatus and methods described herein relate to flow diverters, replacement valves, etc., e.g., for treatment of varicocele and associated conditions.

An apparatus includes an elongated medical dilator including a cautery device configured to selectively form, by cauterization, a tissue passage through a tissue portion of a living body. The elongated medical dilator also includes a dilation device configured to dilate the tissue passage once the cautery device selectively formed the tissue passage.

Exhaust removal apparatus and methods for cryogenic treatment are described herein. The apparatus may generally include a housing having an inlet for fluidly coupling to a source of water and an outlet for fluidly coupling to a drain, and a suction chamber in fluid communication with the housing, wherein the suction chamber is further configured to be detachably coupled to an exhaust collection reservoir having a volume of exhaust gas. Introduction of water through the inlet generates a pressure reduction within the suction chamber such that the volume of exhaust gas is drawn from the exhaust collection reservoir and into the housing for dissolving into the water and out through the drain.

Devices and methods for treating rhinitis are provided. An integrated therapy and imaging device is provided for single handheld use. The device may have a hollow elongated cannula, a therapeutic element coupled to a distal portion of the cannula, an imaging assembly coupled to the cannula to provide visualization of the therapeutic element, and an articulating region operably coupled to the imaging assembly to articulate the imaging assembly. The imaging assembly may be articulated so as to translate vertically, laterally, axially, and/or rotationally.