This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.

An electrosurgical ablation device provides pulse width modulated DC power to a heating segment in a catheter for use in providing treatment. In some embodiments the DC power to be modulated is sourced from an AC/DC power converter coupled to a source of AC power. In some embodiments the DC power to be modulated is sourced from a battery. In some embodiments the device switchably selects for modulation DC power sourced from either the AC/DC power converter or the battery, for example based on availability of power from the AC/DC power converter.

The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

An electrosurgical generator configured to generate electrical energy to be applied to biological tissue via electrical communication with an electrosurgical instrument, the electrosurgical generator including a power source configured to activate to output the electrical energy to the electrosurgical instrument, a measurement circuit configured to measure a resistive value associated with an erodible coating deposited on a portion of the electrosurgical instrument, and a control circuit configured to compare a measured resistive value of the erodible coating to a threshold resistive value of the coating, and control activation of the power source based on the comparison between the measured resistive value and the threshold resistive value.

A high frequency treatment instrument can be opened and closed between a first grasping jaw and a second grasping jaw. A lumen is formed inside the first grasping jaw. The first grasping jaw includes an electrode disposed on a side toward which the first gasping jaw is closed, with respect to the lumen. The electrode has an electrode surface arranged opposite the second grasping jaw and extending from a proximal end portion to a distal end portion of the first grasping jaw. The first grasping jaw has a distal end wall disposed opposing from a distal end side of the first grasping jaw toward a distal end edge of the electrode surface, and a clearance between the distal end edge of the electrode surface and the distal end wall communicates to the lumen and opens toward the side toward which the first grasping jaw is closed.

An end effector of an electrosurgical device may include a first body, a first electrode on the left side of the first body, and a second electrode on the right side of the first body. The first and second electrodes may be configured to receive electrosurgical energy to treat tissue in a target treatment zone. The end effector may also include a fluid aspiration port in fluid communication with a fluid path. The fluid aspiration port may be configured to remove a material from the target treatment zone.

Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.

A medical punching/cauterizing device includes a handle having a body, a cap detachably coupled to a front portion of the body, a connection terminal coupled to the body and electrically connected to a power supply means, a conductor provided in the front portion of the body and having one end electrically connected to the connection terminal, and a guide wire provided on a front portion of the handle and having one end electrically connected to the conductor.