The present invention provides a method for treating a dermatological condition in a subject, comprising administering to the subjects skin a bioactive composition using a microneedle delivery device, wherein the bioactive composition comprises an effective amount of an anesthetic; administering an effective amount of electromagnetic radiation to the subjects skin to induce damage to the epidermis and/or dermis; and optionally administering to the subjects skin an effective amount of a composition to promote wound healing.

A medical device, including: a cooling system; a heating system; and an applicator including a cold base operationally coupled to the cooling system and a heating element operationally coupled to the heating system, and an applicator head collocated with the cold base and the heating element and adapted for applying a combination of heat and cold to a target area such as target tissue.

Methods and systems are disclosed for removing a tattoo from a subject's skin by application of a cold plasma that is delivered via a liquid-gas mixture. The plasma can be delivered in the form of gas bubbles, in which at least a portion of gas is in the form of a plasma.

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.

Provided herein are methods and devices for inductively heating a tissue to effect a biological response in the tissue or in a biomolecule comprising the same. The methods and devices comprise means for applying a high frequency alternating magnetic field via an inductive coil comprising an applicator to the tissue and means for monitoring feedback from the alternating magnetic field to control and/or adjust heat, for example, in the tissue, which further includes a means for cooling the tissue. Particularly, the device may be a hand held piece that incorporates or has at least an applicator, including a radiofrequency energy generator and output, an inductive coil, an impedance matching system, a cooling system, including a thermally conductive surface and a coolant housing containing a coolant that circulates through the thermally conductive surface, and a feedback monitor. Optionally, the device may comprise a tissue-shaper.

A laser treatment system includes a laser device configured to produce a laser beam at a wavelength in an ultraviolet spectrum to provide for tissue ablation, a lens configured to focus and direct the laser beam to a site to form an opening in a surface of the site, a valve connected to a first channel, and a nozzle that emits the laser beam and controls delivery of at least a first substance and a second substance to the site. A portion of the first channel is disposed within a first sidewall of the nozzle to deliver the first substance, and a second channel unconnected with the valve is disposed within a second sidewall of the nozzle to deliver the second substance.

Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

A medical skin wrinkle reduction device using an RRSS laser irradiation method is proposed to reduce skin wrinkles and minimize tissue damage. The device includes: a main body having a mounting groove provided in an upper portion thereof, a tablet computer being attached to and detached from the mounting groove, and comprising signal transmission and reception parts exchanging signals with the tablet computer, and a microcomputer controlling an output of a laser beam; a handpiece comprising: a laser oscillation part generating the laser beam; an optical part emitting the laser beam as parallel light; a laser scanner controlling an irradiation position of the laser beam transmitted from the optical part; a laser pattern part having movement coordinate values set therein such that moving direction of the laser beam has a regular pattern; a tablet computer having functions of inputting data in a touch screen method and displaying a screen.

Provided herein is a multifunctional aesthetic system including a housing, an electromagnetic array situated in the housing and having a plurality of electromagnetic radiation (EMR) sources, each EMR source configured to generate an EMR beam having a wavelength different than that of an EMR beam generated by another of the EMR sources, a controller in electronic communication with the array to operate two or more of the EMR sources to direct the EMR beam to a treatment area, and a sensor in electronic communication with the controller for providing feedback to the controller based on defined parameters to allow the controller to adjust at least one operating condition of the multifunctional system in response to the feedback.

The invention provides a tip that permits therapeutic electromagnetic energy systems to deliver multiple beams of overlapping, partially overlapping, and non-overlapping electromagnetic energy in the treatment of tissue disorders and conditions. The tip finds use with laser systems, intense pulsed light systems, LED systems, radiofrequency systems, and microwave systems.