The present invention is concerned with a hair removal device for removal of red hairs that has a light emission unit having a substrate and a plurality of first LED dies emitting at a peak emission wavelength in a wavelength range of between about 480 nm and about 510 nm, the first LED dies being mounted on the substrate on an area in the range of between about 0.2 cm.sup.2 and about 100 cm.sup.2, wherein the hair removal device is arranged to emit a treatment light pulse by the first LED dies having a pulse length in the range of between about 30 ms and about 200 ms, and the first LED dies have a radiant flux such that a radiant fluence on the skin of a user in the range of between about 3 J/cm.sup.2 and about 6 J/cm.sup.2 is achieved by application of the treatment light pulse.

The present invention is concerned with a skin treatment device, in particular a temporal hair removal device, having a light emission unit having a substrate, a plurality of first LED dies mounted on the substrate on an area of at least 0.2 cm.sup.2, in particular of at least 1.0 cm.sup.2, where the first LED dies are each arranged for emitting light at a first peak emission wavelength in the far red or infrared wavelength range of between 700 nm and 980 nm, and at least one second LED die arranged for emitting light at a second peak emission wavelength in the visible wavelength range of between 400 nm and below 700 nm, wherein the skin treatment device is arranged to activate the first LED dies to emit a treatment light pulse, the treatment light pulse in particular having a pulse length of between 10 ms and 300 ms, and the first LED dies have a radiant flux such that a radiant fluence on the skin of a user of at least 1 J/cm.sup.2 is achieved by application of the treatment light pulse, and the skin treatment device is arranged to activate the at least one second LED die to emit a visible light pulse simultaneously with the emission of the treatment light pulse.

An aesthetic treatment device uses multiple light sources, lasers or LEDs focused on the treatment area from different directions. The multiple light sources for treatment purposes could have the same wavelength or different wavelengths each optimized for a different application. Target selection is performed by a dual wavelength smart illumination system combined with an imaging system, a smart processor for target recognition and a scanning system that directs the focused light from laser sources to an automatically selected treatment area. A motorized optical system performs a dual role of: focusing the laser sources and also steering the focused light to specific locations as designated by the imaging and processing systems.

Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.

Methods and apparatuses are provided for reducing sweat production via, for example, the removal, disablement, and incapacitation of sweat glands in the epidermis, dermis and subdermal tissue regions of a patient. In one embodiment, a method of treating a patient is provided which involves identifying a patient having a condition of excessive sweating, positioning an energy delivery device proximate to a skin tissue of the patient and delivering energy to sweat glands to halt secretion of sweat. The energy delivery device may include microwave delivery devices, RF delivery devices, and cryogenic therapy devices. Some embodiments may include using a cooling element for avoiding destruction of non-target tissue and/or a suction device to localize treatment at specific portions of the skin fold.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

A method for treating a skin lesion can include lowering a temperature of a treatment site to a temperature range sufficient to induce vasoconstriction in a dermis of the treatment site and administering a laser light through a medium to the skin lesion while maintaining the temperature of the treatment site within the temperature range. The medium can include a first portion and a second portion, where the laser light is transmitted through the first portion and the second portion sequentially, the second portion includes a contact surface for contacting the treatment site, and the second portion has a higher thermal conductivity than the first portion. The method can further include identifying the skin lesion and analyzing one or more characteristics of the skin lesion.

The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and/or promoting hair follicle development and/or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.

There is provided a hair cutting device for cutting hair on a body of a subject, the hair cutting device comprising a light source for generating light at one or more specific wavelengths corresponding to wavelengths absorbed by one or more chromophores in or on hair; a cutting element that comprises an optical waveguide that is coupled at a first end to the light source to receive light, wherein a portion of a sidewall of the optical waveguide forms a cutting face for contacting hair; a light sensor that is coupled to the optical waveguide away from the first end, wherein the light sensor is for measuring the light level in the optical waveguide and for providing an output signal representing the measured light level; and a control unit that is coupled to the light source, and coupled to the light sensor to receive the output signal, wherein the control unit is configured to determine a measure of the amount of input light transmitted across the optical waveguide from the measured light level and an input light level at the first end of the optical waveguide; and to control the power of the light generated by the light source based on the determined measure.

A mass spectrometry imaging system includes an ionization source located at a first location configured to produce ions from a surface of a sample at the first location; a mass spectrometer located at a second location configured to perform mass spectrometry analysis by analyzing the produced ions based on mass to charge ratio of the ions; and an ion transfer device configured to transfer the ions from the first location to the second location such that the ion transfer device includes a plurality of electrodes, the plurality of electrodes configured to be flexible or flexibly connected to each other, and the ion transfer device is configured to be flexible or re-configurable while transferring the ions.