This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

An apparatus for supply of coolant, particularly CO.sub.2 that is preferably provided in bottles, to cryosurgical instruments. The device may be a mechanical or thermal compression device. A pump may supply the CO.sub.2 taken from the bottle in a buffer container with a desired operation pressure. The pressure in the gas bottle can be less than the desired operation pressure. The apparatus includes a tempering device that is configured to bring the coolant to a desired temperature, particularly a temperature that is higher than the temperature in the gas bottle or in another storage container.

A cryogenic balloon catheter having a heating function, the cryogenic balloon catheter comprising a catheter, an external power source, wherein an outer wall of the catheter comprises an inner layer, a middle layer and an outer layer, which are sequentially arranged from inside to outside, the middle layer comprising a metal woven mesh, and the metal woven mesh, the temperature controller and the external power source forming a power supply circuit. In the cryogenic balloon catheter, the middle layer of the outer wall of the cryogenic balloon catheter is provided with the metal woven mesh having a heat conduction function, and the metal woven mesh is connected to the external power source, such that the metal woven mesh can generate heat after being powered, so as to ensure that the temperature of the outer surface of the catheter is maintained within set temperatures, thereby ensuring the cryogenic ablation effect.

The present invention relates to a treatment apparatus including a housing, an insertion unit provided on one side of the housing and formed to be inserted into a tissue through a tissue surface, and a cooling unit cooling the one side of the insertion unit within the housing to prevent thermal damage to the tissue touched when the insertion unit heated during a treatment time is drawn out from or inserted into the tissue, and a method of controlling the same and a treatment method. According to the present invention have effects in that they can prevent a problem in that unnecessary damage to a tissue occurs while maintaining a treatment effect of the skin because the heated end of the insertion unit is cooled and moved.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.

Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

The present disclosure relates to a mask, a device and a method for whitening skin. In an embodiment, the mask includes a contact layer having a lower portion configured to contact a face surface of a user, and at least one thermoelectric module including a first major surface disposed in contact with an upper portion of the contact layer and a second major surface positioned opposite to the first major surface. The mask also includes a heat dissipation layer being disposed in contact with the second major surface of the thermoelectric module. The mask further includes a controller configured to control the thermoelectric module to: cool the first major surface at a cooling temperature such that the skin of the user reaches a target temperature at which a pigmentation by melanocytes on the user's skin is suppressed, and maintain the cooling of the first major surface for a cooling interval.

Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.