Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery.

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.

A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.

An electrochemical reactor includes positive and negative electrodes. A conductive and/or dielectric liquid is provided between the positive and negative electrodes. A first isolation member provided on the positive electrode isolates the positive electrode from the liquid, and a second isolation member provided on the negative electrode isolates the negative electrode from the liquid. The first and second isolation member each includes a liquid-repellent porous membrane. The reactor further includes a pressure-applying member which pressurizes the liquid to fill the pores of the first and second liquid-repellent porous membranes with the liquid, thereby causing an electrochemical reaction involving the positive and negative electrodes.

An implantable medical device, for implantation in a mammal knee joint, comprising an artificial contacting surface adapted to replace at least one contacting surface of the knee joint and to be lubricated when implanted in said joint. The medical device further comprises a reservoir comprising a movable wall portion defining the volume of the reservoir, at least one inlet adapted to receive a lubricating fluid from the reservoir, at least one channel at least partly integrated in said artificial contacting surface, wherein the channel is fluidly connected with said at least one inlet for distributing said lubricating fluid to the surface of said artificial contacting surface. The medical device further comprises an operation device adapted to non-invasively transport said lubricating fluid from said reservoir to said artificial contacting surface, and an implantable injection port for refilling said reservoir, wherein the movable wall portion is moved when the reservoir is refilled, such that the volume of the reservoir is increased.

A system may comprise a liquid source from which a liquid is delivered, and a catheter coupled to the liquid source. The catheter may include a distal portion from which the liquid is released into an anatomic lumen. The system may also include an occlusion device coupled to the catheter and configured to prevent flow of the liquid in the anatomic lumen proximally of the occlusion device. The system may also include a heating device near the distal portion of the catheter. The heating device may be configured to heat the liquid to a temperature of less than a vaporization temperature for the liquid.

Various aspects of the invention relate to methods and devices for treating diseases and conditions including atherosclerosis and endocarditis using low-temperature, non-equilibrium plasmas. A device may be, for example, a catheter that carries electrodes and a dielectric material for generating a localized, non-equilibrium plasma in a bodily fluid such as blood.

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.

A system for treating target tissue located at a first location along an anatomic lumen comprises a catheter including a distal end portion configured for deployment in the anatomic lumen. The system also comprises an expansion device coupled to the distal end portion of the catheter. The expansion device has an expanded size in a deployed configuration. The expansion device in the deployed configuration occludes the anatomic lumen at a second location, different from the first location, along the anatomic lumen. The expansion device also occludes at least one of a plurality of blood vessels adjacent the anatomic lumen to reduce blood flow to the target tissue at the first location.