An electro-chemical surgical knife is detailed that in a single instrument provides both a chemically assisted mechanical dissector and an electrical knife. The chemically assisted mechanical dissector: includes a conductive mechanical instrument, a source, (7), of cleavage solution, a pump, (8), for feeding the cleavage solution to, a channel, (2), for transporting the cleavage solution to the operating location, and a flow controller, (8c), for controlling the volumetric feeding of cleavage solution by the pump to the channel inlet. The electric knife includes a source of high frequency AC electrical power, (5), for feeding AC current through an electric conductor, (3), to, an electrode, (6), formed by the conductive mechanical instrument and further comprises A second controller, (5c), for controlling the feeding of electric current to the electrode.

Various embodiments of ablation elements are disclosed herein, where the ablation element includes a biodegradable shell. Calcium chloride is retained within the biodegradable shell. When the ablation element is delivered to a target location within the body of a patent, the biodegradable shell degrades to release the calcium chloride. A reaction between the released calcium chloride and bodily fluids will generate heat, which in turn will ablate biological material in proximity to the reactive region.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

An ablation needle device is a needle device intended for an ablation treatment of an adrenal tumor with transvenous introduction of an injection needle into an adrenal gland. The ablation needle device includes a metal injection needle including a pointed tubular distal portion and a tubular proximal portion, and a grip portion attached to a proximal side of the injection needle. The proximal portion of the injection needle is given flexibility by forming a helical slit in a distal region of the proximal portion. An outer surface of the proximal portion is coated with resin. A distal end of the distal portion of the injection needle is closed. A plurality of fine holes are formed in an outer surface of the distal portion including the closed part. The grip portion has a liquid-injection port for supplying liquid into the lumen of the injection needle.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

Compositions, systems, devices, and methods for performing precise chemical treatment of tissues are disclosed. Systems, devices, and methods for administering a chemical agent to one or more a precise regions within a tissue mass are disclosed. Compositions, systems, devices, and methods for treating targeted regions within a tissue mass are disclosed.

An ablation device includes a handle assembly including a distal end and a probe extending distally from the distal end of the handle assembly. The probe includes a heat-transfer portion and at least one fluid-flow path in fluid communication with the heat-transfer portion. The handle assembly includes at least one fluid reservoir in fluid communication with the at least one fluid-flow path and at least one apparatus configured to cause fluid flow between the at least one fluid reservoir and the heat-transfer portion. The probe is configured to apply thermal energy released by an exothermic chemical reaction that occurs when fluid from the at least one fluid reservoir is caused to flow to the heat-transfer portion.

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions are disclosed.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.