An esophageal ablation system including a positioner, an elongated, flexible shaft extending from the positioner, and a microwave emitter assembly disposed near the distal end of the shaft. The emitter assembly includes one or more microwave antennae and a balloon for spacing the antennae relative to target tissue. The device may have an inner balloon for deploying the antenna. The systems, devices and methods disclosed are useful for treating Barrett's Esophagus, Esophageal Adenocarcinoma, and Squamous Cell Carcinoma.

An energy delivery system includes an RF synthesizer circuit configured to generate an RF electric signal and a preamplification stage operably coupled to the RF synthesizer circuit. The preamplification stage has at least one attenuator. A board controller is operably coupled to the attenuator of the preamplification stage that is configured to modify a gain setting of the attenuator. An output connection is configured to provide a low-power signal or a high-power signal based on at least the RF electric signal and the gain setting. The low-power signal or high-power signal is provided to an RF applicator configured to couple an alternating RF electric field to animal tissue.

An electrosurgical ablation apparatus for generating and emitting electromagnetic radiation energy for ablating biological tissue is disclosed. The apparatus comprises an operating unit (1), a handheld applicator unit (3) with an applicator antenna (4) and a cable connection (2) between both. The applicator antenna (4) is a dual or multi-resonant ablation antenna (41a, . . . 41d) for transmitting microwave ablation energy at at least two different frequencies which are selected especially according to the electrical properties and dimensions of the tissue to be ablated.

Described herein are methods and apparatus for treating or preventing epidermal dysplasias, including, for example, dysplastic epidermal lesions and dermatological pre-cancerous disease.

A multicarrier ablation system comprising: an antenna for application to biological tissue; a multi-carrier signal generator configured to provide a forward radio frequency (RF) signal to the antenna, the forward RF signal comprising multiple subcarriers that occupy respective frequencies within a bandwidth of the RF signal; and a monitoring circuit configured to receive a reflected RF signal from the antenna and control the multi-carrier signal generator to adjust one or more parameters of the forward RF signal during an ablation procedure based on the reflected RF signal.

An esophageal ablation system including a positioner, an elongated, flexible shaft extending from the positioner, and a microwave emitter assembly disposed near the distal end of the shaft. The emitter assembly includes one or more microwave antennae and a balloon for spacing the antennae relative to target tissue. The device may have an inner balloon for deploying the antenna. The systems, devices and methods disclosed are useful for treating Barrett's Esophagus, Esophageal Adenocarcinoma, and Squamous Cell Carcinoma.

An electrosurgical resection instrument for applying to biological tissue radiofrequency electromagnetic energy has a protective hull comprising a shaped piece of dielectric material mounted to cover an underside of an instrument tip of the instrument. The protective hull acts as a shield to protect tissue that may lie under the instrument tip from damage during treatment. The instrument may be particularly useful in procedures performed in a gastrointestinal tract, where bowel perforation concern, or in the pancreas, where damage to the portal vein or the pancreatic duct may occur when a tumor or other abnormality is being resected, dissected or removed.

An electrosurgical instrument with a radiating tip portion having a relative permeability and/or relative permittivity that is selected to provide an electrical length for the radiating tip portion that enables effective delivery into biological tissue of microwave EM energy supplied thereto, at two or more frequencies of choice. The instrument has a radiating tip portion disposed to receive microwave EM energy from a coaxial cable, the radiating tip portion having a first effective relative permeability at a first frequency and a second effective relative permeability at a second frequency.

An energy delivery system and methods for an ablation procedure may include a generator configured to generate an electrical signal having an operating frequency for an ablation operation and an ablation probe coupled to the generator and configured to receive the electrical signal from the generator. The ablation probe may include a flexible body portion including an inner conductor, an outer conductor, and a dielectric between the inner and outer conductors. The ablation probe may further include a radiating portion electrically coupled to the inner conductor, where the radiating portion is configured to radiate energy received from the electrical signal. A length of the radiating portion may be between 0.35 and 0.65 times an operating wavelength, where the operating wavelength is dependent on the operating frequency of the electrical signal.

An electrosurgical resection instrument for applying to biological tissue radiofrequency electromagnetic energy has a protective hull comprising a shaped piece of dielectric material mounted to cover an underside of an instrument tip of the instrument. The protective hull acts as a shield to protect tissue that may lie under the instrument tip from damage during treatment. The instrument may be particularly useful in procedures performed in a gastrointestinal tract, where bowel perforation is a concern, or in the pancreas, where damage to the portal vein or the pancreatic duct may occur when a tumor or other abnormality is being resected, dissected or removed.